DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and wu:fb13g09

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_009289330.1	Gene:	wu:fb13g09 / 336563	ZFINID:	ZDB-GENE-030131-8507	Length:	1393	Species:	Danio rerio

Alignment Length:	1389	Identity:	448/1389 - (32%)
Similarity:	682/1389 - (49%)	Gaps:	180/1389 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RQPNPVTKANFFSKWFFIWTREILVKGLQRN-LDPSDLYET---EPSLESTQVSSFLLGHWEQEL 68
            :..:||..|.|||.....|...:..:..:.: |...|::..   |.|..:.|...:|   |.:||
Zfish    57 KHQHPVDNAGFFSFMTLQWLSPLAWRAHKDSCLKMEDVWGLSCHEASETNCQRLEWL---WHEEL 118

  Fly    69 KRSKPN--VLRMIFKAYGWSFVPASIVYSIMA-----IAVHTTQPLMLGGLVSFFSESTGKITKH 126
            ||...:  .|..:|    |.|....::.:|.:     :|......|::..|:.|...|..|:
Zfish   119 KRRGKDGASLSRVF----WRFCQTRMLVAIFSLLITMVAGFVGPALLIRALLEFSQCSEVKL--- 176

  Fly   127 SAYLYAMGVVLCSLISGLFFH--------PFMKYL-FRVGSRVRLACAGLVYRKFLRVSVAADNS 182
               ||.:     :|::|:|..        .||..: :|..:|:|.|.....::|.||:....|.|
Zfish   177 ---LYGL-----ALVAGIFLMELTRSWSLAFMWAINYRTAARLRGAALTFAFQKILRLRSTKDVS 233

  Fly   183 GVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVV-FVYIIYQLIGWPAVVGLGTIVAFIPLQA 246
              ||..:::.|:|.....|:......|..|||.|:: ..|..| .:|..|:||....:.|.|...
Zfish   234 --SGELVNICASDGQRLYEAVSVGCLLAGGPLVGMLGLTYTTY-FLGPTALVGSAIFIIFYPTMM 295

  Fly   247 WAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIY 311
            .|:|..|.:::....|.|.||:|||||:..|:.||||.||..||..|.|||.||.
Zfish   296 LASRMTAYFRKKCVAVTDRRVRLMNEILGCMKFIKMYCWETPFANNIQKVRSEER---------- 350

  Fly   312 AGLQCTGMISKLSLFLSLVTYV------FT-----GDIVTSQKVFIVASYYDHLNDSLLHSWPLA 365
            ..|:..|.:..|:|.::.|..|      ||     |..:|:.:.|.|.:.::.:..:|..: |||
Zfish   351 RNLEWAGCVQSLTLGVAPVVVVIASVCTFTLHMALGYDLTAAQAFTVVAVFNSMTFALKVT-PLA 414

  Fly   366 INMWVETFVVANRV-KDFLFQH--------ENPADGGVHNFKEA--------------------- 400
            :....|..|...|. |.|:.:.        |:|.:  |..||:|
Zfish   415 VRALSEGSVAVKRFQKLFMMEDRELISVKTEDPYN--VVEFKDATLAWEKTCGSQTKKSRTQLKR 477

  Fly   401 ------------------EDNPEHGNFFGRTHKPKAEVKSITVH------KLSASWDQKKQEKRH 441
                              |:|.      |:..:|.||  .:..|      :.:.|..|..:...|
Zfish   478 GGMKRVLRREKLSLYIITEENK------GKIEEPNAE--HLLTHMEQESPQSTISSTQSIRPPLH 534

  Fly   442 RHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLR 506
            :.:..:....|....||:.|.||:|||:||..:||::.::.|||.|||..:|..|:.|:|..|||
Zfish   535 KTLHRIDLCIQKGSLVGVCGGVGSGKSSLLSALLGQMTLLGGSVSVNGGFAYVAQQAWILNDSLR 599

  Fly   507 DNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADI 571
            :||||.:.|:|::|..||..|.|..|:.:||.||.|.:||.||:|||||:.|||||||:|.:..|
Zfish   600 ENILFGKKYNEEKYNAVLEACCLFPDIIELPYGDMTEIGERGANLSGGQRQRVSLARALYSERPI 664

  Fly   572 YLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDAL 636
            .||||||||||:.|...|....:......|..|.|||::|.|...|.:||::.|:|:..|.:..|
Zfish   665 LLLDDPLSAVDARVGSRLFHSAIRPAAKGKTVIFVTHQLQYLPECDDVVLMKDGQIAEHGTHTQL 729

  Fly   637 KKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHM--------DRHEIEQQFK-EQQ 692
            .:..|...::.|.|:...|  :|.:...:|...::|..|..|:        :..:.:|..: |::
Zfish   730 MEKGRDYAALFNSVQQENL--VRKNLKNKEKAEKESSPQTLHVSNPPKPDTESKKTDQLMQAEEK 792

  Fly   693 QIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKW----------------AT 741
            ..|:|....|..|.|..|.||..::.:|:|:....|.|..:.:||.|                |.
Zfish   793 GSGAVAWPVYAAYIKAAGGPLAFIVTILLFLFTTGSIAFSNWWLSYWIRQGSGNSSLLLGNETAE 857

  Fly   742 WEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIR 806
            .:....|.|  |..|.|       :|...:...|....:|...|...|:|.:..:||:||:.::.
Zfish   858 SDSMRLNPH--IQYYSR-------VYVLSMGAALFLKTIRGLVFVKCTVRAASVLHDKLFKTLLL 913

  Fly   807 AFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVV 871
            :.|.||.....||||||||.|:..:||.|.......::.....|..|.||.....|.|.....:.
Zfish   914 SPMRFFDTTPLGRILNRFSKDMDEVDVRLAMQAEMLLQNVTLVLFCLGVVGAVFPWFLFSIIPLG 978

  Fly   872 ALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRAL-NGTKYMERDFHYYQ---NE 932
            |.|:....:.....|.|||:|.||:||..||..::.:||:||.|. .|..::    |.||   :.
Zfish   979 AFLFIVNRISRVLIRELKRLENISQSPFTSHITSSLQGLSTIYAYGRGADFI----HRYQALLDT 1039

  Fly   933 NTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKH--RGYYSGDVGLAITQSMKLVLMCQ 995
            |.:..:|.....|..|...|||.:..|..|....:|...|  ..|    .|||::.:::|..:.|
Zfish  1040 NQACQFLFSCAMRWLAVRLDLISISLITTVALLIVLMHGHISPAY----AGLALSYAVQLTGLFQ 1100

  Fly   996 AGMRQTVELENMMTSVERVMEYV-NIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPY 1059
            ..:|...|.|...|||||:..|: |:.||...:..........||:.||:.|:|:.:||.:..|.
Zfish  1101 FTVRLLSETEARFTSVERINHYIKNLESEGPRQITGCPTSSSSWPAEGQITFQDVEMRYRDGLPL 1165

  Fly  1060 ILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHIN-GHISIDGFETSQLGLHDLRRRISII 1123
            :||.|.|:|..||.|||||.|.:||||:..||||||.:: |.|.|||...:.:||.|||.::|:|
Zfish  1166 VLKNLCFSILPEETIGIVGRTGSGKSSLGVALFRLAELSRGSIIIDGVNIAHIGLEDLRSKLSVI 1230

  Fly  1124 PQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLV 1188
            ||:||||.|::|.||||:::.||.::|.|||...:|:.||.|.:.::..:.|.|.|||:|:|||:
Zfish  1231 PQEPVLFIGTVRSNLDPWDQYTDAQIWEALEKTHIKDMVSQLPNSLHSEVTDNGENFSVGERQLL 1295

  Fly  1189 CLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMG 1253
            |:||||||.:|||::|||||.:|.|||.|||:.|.:.|:.||.|.|||||:||:..:|:||:|.|
Zfish  1296 CVARALLRHSKILLLDEATAAIDTETDRLIQDTIRSSFSGCTTLVIAHRLNTVLGCNRIMVLDQG 1360

  Fly  1254 RVVELGHPHELLHNRHGYLHRFVE 1277
            :::|...|..||.:.:...|..:|
Zfish  1361 QILEFDTPSNLLTDENSRFHAMME 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	446/1377 (32%)
		ABC_membrane	92..358	CDD:294371	80/291 (27%)
		ABCC_MRP_domain1	423..626	CDD:213217	87/208 (42%)
		ABC_membrane	762..988	CDD:294371	68/231 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	113/219 (52%)
wu:fb13g09	XP_009289330.1	SunT	61..1386	CDD:331423	448/1385 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750