DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcc5

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001182542.1	Gene:	abcc5 / 336147	ZFINID:	ZDB-GENE-050517-17	Length:	1426	Species:	Danio rerio

Alignment Length:	1371	Identity:	437/1371 - (31%)
Similarity:	688/1371 - (50%)	Gaps:	168/1371 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NPVTKANFFSKWFFIWTREILV----KGLQRNLDPSDLYETEPSLESTQVS-SFLLGHWEQELKR 70
            :||..|..||...|.|...:.|    ||   .|...|::... ..||.::: ..|.|.||:|: |
Zfish    94 HPVDNAGLFSFMTFNWLTSLAVLAHKKG---QLFLEDIWAVS-QFESCEINRRRLAGLWEEEI-R 153

  Fly    71 SKPN--VLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFS---------ESTGKIT 124
            |:.|  .||.:.    |.|....::.||:.        ||:..|..|.|         |.|.:..
Zfish   154 SRGNDASLRRVV----WHFCRTRLLLSILC--------LMVTQLAGFSSPAFVVWRLLEYTQRSE 206

  Fly   125 KHSAY--LYAMGVVLCSLISGLFFHPFMKYL-FRVGSRVRLACAGLVYRKFLRVSVAADNSGVSG 186
            ....|  |..:|::...||.. :.|.....| :|.|:|:|.|...:.:.|.||:....:.|  .|
Zfish   207 PDLPYGLLLVLGLLATELIRS-WSHALTWALNYRTGTRLRGAILTMAFHKILRLRSLREKS--MG 268

  Fly   187 YAISLMATDLPTFNESFYCFHELWRGPLEGVV-FVYIIYQLIGWPAVVGLGTIVAFIPLQAWAAR 250
            ..|::.:.|.....|:......|..|||..|: ..|.:: ::|..:::|....:.|.|...:::|
Zfish   269 ELINMCSGDGQRMFEAAAVGSLLAGGPLVAVLGMAYNLF-VLGPTSLLGSAVFILFYPTMMFSSR 332

  Fly   251 AIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTY---IYA 312
            ..|.::|....|.|:||:.||||:..::.||||||.|:|::.:.::|.||...:..:.|   |..
Zfish   333 LTAYFRRKGVAVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRIRDEERQILERTGYFQSITV 397

  Fly   313 GLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVAN 377
            |:  ..::..::...:..|::..|..:|:.:.|.|.:.::.:..:|..: |.::....|..|..:
Zfish   398 GV--APIVVVIASVATFSTHMLLGYDLTAAQAFTVVTVFNAMTFALKVT-PFSVKSLSEASVAID 459

  Fly   378 RVKDFLFQHE---------NPA------------DGGVHNF------------------KEAEDN 403
            |.|..|...|         ||:            :.|.|:.                  :...|.
Zfish   460 RFKSLLLMAEVKMIRELPRNPSVAVEMSGASLAWETGGHSAQPSPRGTPHVGTRGCRKKRRQRDV 524

  Fly   404 PEHGNFF-GRTH---------KPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVG 458
            |:|.... ..||         :..:..|..|:|..:.|  |:.|  |..|..|:|.  |..:.||
Zfish   525 PKHHAILEEETHGQLLNDVSGEMASSPKDQTLHVPTIS--QRLQ--RTLHCIDLSI--QKGKLVG 583

  Fly   459 IVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEV 523
            :.|:||:||::|:..|||::.::.|:|.|:|..:|..|:.|:|..|.||||||.:..:|:||..:
Zfish   584 VCGSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFGKEMEEERYQAI 648

  Fly   524 LRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKM 588
            |..|.|..|:..||.||.|.:||.||:|||||:.|:|||||:|....||:|||||||:|:||...
Zfish   649 LSACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDPLSALDAHVGNH 713

  Fly   589 LLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVA 653
            :.:..:.:.|..|..|.|||::|.|...|.::::..|.|:.||.::.|..:.....::.|::::.
Zfish   714 IFNNAIKKQLRGKTVIFVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGDYAAMFNNLQLG 778

  Fly   654 KLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQ---------QQI-----GSVKLQTYKE 704
            :      ..:.|.|..:...|.::.:::.:.....||:         .|:     |||....||.
Zfish   779 E------TPIIEVPNKKSGSSLKKPLEKSKAGSVKKEKSTTQGDGQLMQVEERGKGSVPWAVYKV 837

  Fly   705 YFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEE-------------TEPNQHEPIPEY 756
            |.:.||...|.:.||.:|::...|.|..:.:|..|.....             :|..:..|:.::
Zfish   838 YIQALGGWPVFLFILALFILNVGSTAFSNWWLCYWIKQGSGNTTVQVGNSSVLSESMRDNPLMQH 902

  Fly   757 HRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRIL 821
            :..      :||..:...|:..:||...|...|||.|.|:||:|||.::|:.|.||....:.|||
Zfish   903 YAA------VYTMSMGVMLLLKLLRGIVFVKGTLRASSRLHDELFQKILRSPMKFFDTTPTARIL 961

  Fly   822 NRFSSDVLAIDVNLP-QAMMDSIEFAVNALAV---LAVVSTANIWLLI---PATVVVALLYGCRC 879
            ||||.|:..:|..|| ||.|    |..|.:.|   |||:.:...|.|:   |..::..:|:....
Zfish   962 NRFSKDMDEVDTRLPFQAEM----FTQNVILVLFCLAVIGSVFPWFLVAVGPLVLLFTVLHVVSR 1022

  Fly   880 LYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERD--FHYYQ---NENTSALYL 939
            ::|   |.|||::.:::||..||..::.:||.|:.|     |.:.|  .|.||   ::|.:..||
Zfish  1023 VFI---RELKRLDNVTQSPFLSHIASSIQGLTTVHA-----YGKEDEFLHRYQELLDQNQAPFYL 1079

  Fly   940 HVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVEL 1004
            .....|..|...|:|.|..|.......:|.  |........||||:.:::|..:.|..:|...|.
Zfish  1080 FSCAMRWLAVRLDVISVALISITALMIVLM--HGQIPPAYAGLAISYAVQLTGLFQFTVRLASET 1142

  Fly  1005 ENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIR 1069
            |...|||||:..|:...|..|....::...|..||..|::.|....::|.::.|.|||..:||:|
Zfish  1143 EARFTSVERIHHYIKSLSLEAPARVKNKAPPSDWPQEGEIVFDQTEMKYRDNLPLILKKASFTVR 1207

  Fly  1070 GEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGS 1133
            .:|||||||.|.:||||:...|:||.. ..|.|.|||.....:||.|:|.::|||||:||||||:
Zfish  1208 PKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNICDIGLADVRSKLSIIPQEPVLFSGT 1272

  Fly  1134 LRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQN 1198
            :|.|||||.:.::.::|.|||...:||.||.|...:...:.:.|.|||:|:|||:|:||.||||.
Zfish  1273 VRSNLDPFSQYSEAQIWDALERTHMKECVSQLPLKLESEVVENGENFSVGERQLLCVARVLLRQC 1337

  Fly  1199 KILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHE 1263
            ||||:|||||.:..|||.||||.|...|..||.||||||:|||:..||:||::.|:|||...|.:
Zfish  1338 KILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIAHRVHTVLSCDRIMVLNQGQVVEFDEPSK 1402

  Fly  1264 LLHNRH 1269
            ||.|.:
Zfish  1403 LLANEN 1408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	436/1368 (32%)
		ABC_membrane	92..358	CDD:294371	69/281 (25%)
		ABCC_MRP_domain1	423..626	CDD:213217	85/202 (42%)
		ABC_membrane	762..988	CDD:294371	77/237 (32%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	112/219 (51%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		16/58 (28%)
		CFTR_protein	95..1419	CDD:273530	437/1370 (32%)
		ABC_membrane	177..441	CDD:294371	68/277 (25%)
		nucleotide binding domain 1	188..248		15/60 (25%)
		transmembrane domain 2	279..379		30/100 (30%)
		nucleotide binding domain 2	403..450		7/47 (15%)
		ABCC_MRP_domain1	552..751	CDD:213217	86/204 (42%)
		ABC_membrane	851..1132	CDD:294371	87/300 (29%)
		ABCC_MRP_domain2	1180..1400	CDD:213211	112/219 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650