Protein Alignment CG11898 and Sur

DIOPT Version :10

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_061511301.1
• Gene: Sur / 3292067
• VectorBaseID: AGAMI1_003204
• Length: 2282
• Species: Anopheles gambiae
• Alignment Length: 1615
• Identity: 383/1615 - (23%)
• Similarity: 630/1615 - (39%)
• Gaps: 531/1615 - (32%)

  Fly   185 SGYAISLMATDLPTFNESFY--CFHELWRGPLEGVVFVYIIYQLIGWPAVVG-LGTIVAFIPLQA 246
            :|...:||:.|  .||...:  ..|.:|..||:..|.:|::|:.:|...|:| :..||...|||.
Mosquito   698 AGTITNLMSDD--AFNVMSFVKMVHYVWAIPLKIAVVMYLLYRQLGISTVIGSVVCIVTMTPLQL 760

  Fly   247 WAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEE-----MDSIRG 306
            ...:.:|...:..::..|||::.:||::..::|||:.|||..|...|.:.|::|     :|||..
Mosquito   761 LIGKLMAANSKKVSECTDERLRRINEVLLGIKLIKLNAWETVFKDKISQARQQELRHLDLDSIYW 825

  Fly   307 S-----TYIYAGLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAI 366
            :     |:|.:.|.   .|..:::||:|......   :|:.::|...:.::.|...|. .:|:.|
Mosquito   826 TLMMLLTHISSVLI---TIVTIAVFLALENNPIE---LTAGRLFASLALFNQLTVPLF-IFPITI 883

  Fly   367 NMWVETFVVANRVKDFLFQHE-------------------------------------------- 387
            .:.:...|...|::.||.|.|
Mosquito   884 PITLSAIVSTGRLEAFLGQPEVERSSLEGIRTMARILSKSDASLDMDEAGDPQYGDDAAAAQEQC 948

  Fly   388 ------NPAD--------------------GGVHNFKEAEDN---------------PEHGNF-- 409
                  .|.|                    |.....::|.||               .:|.:.
Mosquito   949 PGVPVVAPPDQVEEGQQLQQPGIKSSDNVTGSPQTERKAADNAGPLPLVEDVGGKSCSQHSSMSS 1013

  Fly   410 ---------------------FGRT-HKPKAEVKSITVHKLSASWDQKKQEKRHR---------- 442
                                 :.:| ..|:.::|..:...:||..::.:|:::|.
Mosquito  1014 DRSIRCEQVDRAPMARQRPAKYQKTVPSPRVKLKKHSQLSVSARLEKCRQKQKHLAREMRFGLPD 1078

  Fly   443 ----HIEDVSFQAQD---------------------QQFVGIVGTVGAGKSTLLQVILGELDIIS 482
                .::|..|:..|                     .:...|||..|:|||:||..:|.|::.:|
Mosquito  1079 HAAVFLKDARFRWNDTGADDTMAHCALHIEQLTVPKAKLTVIVGRSGSGKSSLLAALLKEINHLS 1143

  Fly   483 GSVEVN--GVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVG 545
            |.:..|  ..::|.||:|||...::|:|:||.|.:..:||..|||.|.|..|::.:|.||.|.:|
Mosquito  1144 GELIWNKYSSIAYVPQKPWLQNATIRENVLFGESFRPKRYDRVLRACALKPDLDLMPAGDGTEIG 1208

  Fly   546 EGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIR--ILVTH 608
            |.|..|||||:.|:::|||:|..|::.:|||||||:|:.|:..:.:..::..|:::.|  ||||.
Mosquito  1209 ERGLKLSGGQRQRIAIARALYSSANVVILDDPLSALDNEVAMDVFENGVHRMLARQKRTIILVTQ 1273

  Fly   609 RVQLLRHVDHLVLLEGGRIS-------VQGHY--------------------------------- 633
            :|||:...|::|::|||.:|       ::.:|
Mosquito  1274 KVQLVHRADNIVVMEGGTVSATGSLTEIENNYPHILREWNAIIAKEQQQSSEAQSSPGRTARERW 1338

  Fly   634 --------------------DALKKLIRFRMSVAN---------------------DVEVAKLRA 657
                                |.:::...|..::||                     :..|| ||.
Mosquito  1339 KLFKNISRISFQRNHATEENDFMERTFYFPRTMANRALFGSRFSAHDFPLPIEDCHEPNVA-LRR 1402

  Fly   658 MRTDSVYEEPEP--------RKSLSQEEHMDRHEIEQQFKE-QQQIG---SVKLQTYKEYFKVLG 710
            ..::.:.::..|        |..|.|.||......:..|:. ..|:|   :....|..:  :...
Mosquito  1403 HYSNRLRKDSPPSSTAVVLRRPPLGQIEHPPGTGHQSVFRALSLQLGTNATTSSSTVNQ--RQQR 1465

  Fly   711 HPLVVVLILLMFVVARSSEATMDIFLSK---------------------------WATWEET--- 745
            .|.|||..:.......||.|..|..|.:                           .|:.::|
Mosquito  1466 QPAVVVRHISFPTTLTSSGALDDDTLYRKRLNQGGTAAHPGQLASAGALSGQRRMLASTDDTGMD 1530

  Fly   746 --EPN--------QHE---------------PIPE------------------------------ 755
              |||        |:|               .|||
Mosquito  1531 GIEPNRTGVLLYGQNEGRNSCEDLKRSSIGFRIPEFLRRMSLRGRRFSNPTEFGRPYREREDGSR 1595

  Fly   756 ---------------------------------------------------------YHRTRLRM 763
                                                                     |.|...||
Mosquito  1596 KSSRKTSSLKSIPKERHYSIKRLLSTISRQSEDTEESSVDYGEAEVSNRLIYDDERKYGRIPARM 1660

  Fly   764 MILYTFLILC----TLIFYV-------LRTFGFFMM------TLRISL----------------- 794
            ..||  ||.|    ..||::       |:.:..|.:      |..||.
Mosquito  1661 YWLY--LISCGPRMVAIFFLSALAQQALKVYTDFWLQEWTDQTATISTIVVPTNGTVADASSPTK 1723

  Fly   795 --------------------------------------RIHDQLFQGVIRAFMHFFTLATSGRIL 821
                                                  |:|.:|...|::..:|||.....|||:
Mosquito  1724 PLEIRRHFHAYVALSAVCIVLAAISVPAGQRAGSNARRRLHRELIASVLQNSIHFFQSVPLGRIM 1788

  Fly   822 NRFSSDVLAIDVNL---PQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIG 883
            ||.|.||..:|..:   .|.::..|...|.|:.:.:||:...|.|.||   :..:.|..:..|..
Mosquito  1789 NRLSIDVAVVDKKIAATSQKLLQFILLCVCAVLINSVVTPYFILLTIP---ICGIYYMVQKFYRA 1850

  Fly   884 ASRSLKRIETISRSPIYSHTNATFKGLATIRAL-NGTKYMERDFHYYQNENTSALYLHVSINRAF 947
            :||.|:|||:::.||:.:|.:.|.:|:.||||. ...::||..|...:..|.:.|.|:.| ||..
Mosquito  1851 SSRELQRIESMTYSPVLAHFSETIEGVTTIRAFGQEARFMEVLFKRMEANNVAQLALNCS-NRWL 1914

  Fly   948 AFWTDLICVLYILAVTFSFLLFDKHR--GYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTS 1010
            ....|.:..:.:.....:.|:....|  ...|..:|||:..:|.:.:.....::...|:|....:
Mosquito  1915 GIALDYLGAIIVFVAILTALITASLRPQSTSSSLIGLAVNYAMLVPIYLNWVVKLFAEMEMYGGA 1979

  Fly  1011 VERVMEYVN-------------------------IPSEPAYETEESVNLPKHWPSGGQLDFRDLR 1050
            |||:..::.                         :|.  :|:|     :|..||..|.:.:..:.
Mosquito  1980 VERIQSFIECDVQRRRLDGGLRGRSSRVVQDTGVVPF--SYKT-----VPISWPLRGVIVYEGVS 2037

  Fly  1051 LRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHIN-GHISIDGFETSQLGLH 1114
            |||.|....|:..|..||...:::||.|.|.:||||:..|||....|. |.|.||..:.:.|...
Mosquito  2038 LRYENQKENIITNLNLTIPAGQRLGICGRTGSGKSSLALALFGALEITAGRILIDDVDIAGLHTD 2102

  Fly  1115 DLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGAN 1179
            :||.|:|||||:.:||.||:|.||||....:|.|||..||..:||..|.:|.||::.::.|....
Mosquito  2103 ELRSRLSIIPQEVMLFGGSVRENLDPRGHFSDLELWNCLELAQLKNVVMSLPDGLDTQISDDKHY 2167

  Fly  1180 FSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDN 1244
            ||.|||||.|||||:||.:..|::||||:::|.||:.|:.:|....|...||:|||||||:::|.
Mosquito  2168 FSSGQRQLFCLARAILRGSVCLVLDEATSSLDTETEKLVLQAAKKAFKGRTVITIAHRLHSLVDY 2232

  Fly  1245 DRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGVGTAQHLRH-LAEQSYRKR 1298
            :||:|::.||:||.|.|.:|...........::.|     .|.:| :.|....||
Mosquito  2233 ERVLVLEQGRIVEDGCPRKLAGKPGSKFGTMLKAT-----DHQQHAIVEDDEAKR 2282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	377/1582 (24%)
Sur	XP_061511301.1	None