DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and CG31793

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster

Alignment Length:	1331	Identity:	528/1331 - (39%)
Similarity:	790/1331 - (59%)	Gaps:	72/1331 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKR---- 70
            |||...|...|...|.:...||.||.::.|.|:|||:|....|:..:.......||.|:.|
  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRK 72

  Fly    71 ----SKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLY 131
                .||:|||:|.:.:||..:.:.|..:.:.:....|.||:|.||:|.|||. |....::|.:|
  Fly    73 GDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEH-GNGHSYNAQIY 136

  Fly   132 AMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDL 196
            |:.::.|.|.|.|..||:|..:..:..::|:|.:..:|||.||:|..:.....:|..::|::.||
  Fly   137 AVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDL 201

  Fly   197 PTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSAD 261
            ..|:.....||.||.||||.::..|.:|:.||..:..|:..:|.::|||.:.:|..::.:..:|.
  Fly   202 NRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTAL 266

  Fly   262 VGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTY---IYAGLQCTGMISKL 323
            ..|:||::|||||:.:|:||||.||:.|.||||::|:.||.|||....   |....:.|  :.::
  Fly   267 RTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEIT--LGRI 329

  Fly   324 SLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHE- 387
            ::|:||:.:|..|..:|:::.|.|.::|:.|..::...:|..::.:.|..|...|:.:|:.:.|
  Fly   330 AIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEA 394

  Fly   388 ----------NPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHR 442
                      ..|:...|..||.|.. .:....|:......|:|:     |.|.|.   ||:...
  Fly   395 NVIDMSERRDEKAEEEQHLLKEVEKR-SYPVGIGKEPDTLVEIKA-----LRARWG---QEQHDL 450

  Fly   443 HIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRD 507
            .:.:|:...:..|.|.::|.||:|||:|:|.|||||...||||:|:|..|||.|||||...|:||
  Fly   451 VLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRD 515

  Fly   508 NILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIY 572
            ||||..|.|:|||..||:.|.|:||:|.|. ||.|.|||.||||||||:||:.|||||||:||:|
  Fly   516 NILFGLPMDKQRYRTVLKRCALERDLELLH-GDGTIVGERGASLSGGQRARICLARAVYRRADVY 579

  Fly   573 LLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALK 637
            ||||||||||:||.:.|.|.|:..||.|::.|||||::|.|...|.:|:::.|.:|..|.|:.:.
  Fly   580 LLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEML 644

  Fly   638 K--------LIRFRMSVANDVEV-------AKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQ 687
            |        |:....:.....|:       .:..|:.|.|........:|:.::|......:..|
  Fly   645 KSGQDFAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQ 709

  Fly   688 FKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEP 752
              |.:..|.:.|..||:||......||.|:::::.:..:...:..|.|||.|.  :.|..:....
  Fly   710 --ESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWV--KNTASSSTLD 770

  Fly   753 IPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATS 817
            |  |:.|.:.:     .|::|.|    |||..||.:|:..|..:|:.:|||:.|..::||....|
  Fly   771 I--YYFTAINV-----GLVICAL----LRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPS 824

  Fly   818 GRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYI 882
            |||||||::|:..:|..:|..|:|.|:..:....::.|:...|.|.||....::...|..|..|:
  Fly   825 GRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYL 889

  Fly   883 GASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAF 947
            ..||.:||:|.::|||:|||.:||..||.||||:...:.:...:..||:.::|..|..||.:|||
  Fly   890 KTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAF 954

  Fly   948 AFWTDLICVLYILAVTF-SFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSV 1011
            .::.||.||.|:::|.. :|.....|.   :|.:||||||::.:..|.|.||||:.||||.||||
  Fly   955 GYYLDLFCVAYVISVILHNFFNPPLHN---AGQIGLAITQALGMTGMVQWGMRQSAELENAMTSV 1016

  Fly  1012 ERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRY--SNHGPYILKGLTFTIRGEEKI 1074
            |||:||.::..|..:.:......||.||..|:|..:||.|||  ..:.|.:||||:|||:..||:
  Fly  1017 ERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKV 1081

  Fly  1075 GIVGHTAAGKSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLD 1139
            ||||.|.|||||:::|||||::.:|.|.||..:|:.:||||||.:||||||:||||||::|:|||
  Fly  1082 GIVGRTGAGKSSLINALFRLSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLD 1146

  Fly  1140 PFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMD 1204
            |||:..|::||.|||.|.|||.:|.|..|:...:.:.|.|||:|||||||||||:||:|:||:||
  Fly  1147 PFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMD 1211

  Fly  1205 EATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELL-HNR 1268
            ||||||||:||.|||..|..||..||||||||||:|:||:|:|:|:|.|.|||.|.|:||| .::
  Fly  1212 EATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASK 1276

  Fly  1269 HGYLHRFVEKTGVGTAQHLRHLAEQSYRKRV 1299
            ....|..|.:||..:..||..:||.:.:..:
  Fly  1277 AKVFHGMVMQTGKASFDHLLKVAENTKQNHI 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	520/1298 (40%)
		ABC_membrane	92..358	CDD:294371	92/268 (34%)
		ABCC_MRP_domain1	423..626	CDD:213217	108/202 (53%)
		ABC_membrane	762..988	CDD:294371	82/226 (36%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	135/220 (61%)
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	519/1295 (40%)
		ABC_membrane	112..364	CDD:294371	90/254 (35%)
		ABCC_MRP_domain1	434..632	CDD:213217	110/206 (53%)
		ABC_membrane	736..955	CDD:294371	76/231 (33%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	135/220 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455736
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.890