DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc5

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_038818.2	Gene:	Abcc5 / 27416	MGIID:	1351644	Length:	1436	Species:	Mus musculus

Alignment Length:	1381	Identity:	435/1381 - (31%)
Similarity:	693/1381 - (50%)	Gaps:	181/1381 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RQPNPVTKANFFSKWFFIW----TREILVKG--LQRNLDPSDLYETEPSLESTQVSSFLLGH-WE 65
            :..:||..|..||...|.|    .|.:..||  |..::.|...|      ||:.|:|..|.. |:
Mouse    96 KHQHPVDNAGLFSYMTFSWLSPLARVVHKKGELLMEDVWPLSKY------ESSDVNSRRLERLWQ 154

  Fly    66 QELKRSKPNV--LRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGG---LVSFFSESTGKITK 125
            :||....|:.  ||.:.    |.|....::.||:.:.:  ||.....|   :|....|.|.....
Mouse   155 EELNEVGPDAASLRRVV----WIFCRTRLILSIVCLMI--TQLAGFSGPAFVVKHLLEYTQATES 213

  Fly   126 HSAY--LYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYA 188
            :..|  |..:|::|..::............:|.|.|:|.|...:.::|.|::....:.|  .|..
Mouse   214 NLQYSLLLVLGLLLTEVVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGEL 276

  Fly   189 ISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLI--GWPAVVGLGTIVAFIPLQAWAARA 251
            |::.:.|.....|:......|..||:  |..:.:||.:|  |....:|....:.|.|...:.:|.
Mouse   277 INICSNDGQRMFEAAAVGSLLAGGPV--VAILGMIYNVIILGPTGFLGSAVFILFYPAMMFVSRL 339

  Fly   252 IARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQC 316
            .|.::|......|:||:.|||::..::.||||||.|:|::.:.|:|:||...:..:.|..:  ..
Mouse   340 TAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGYFQS--IT 402

  Fly   317 TGMISKLSLFLSLVTY---VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANR 378
            .|:...:.:..|:||:   :..|..:|:.:.|.|.:.::.:..:|..: |.::....|..|..:|
Mouse   403 VGVAPIVVVIASVVTFSVHMTLGFHLTAAQAFTVVTVFNSMTFALKVT-PFSVKSLSEASVAVDR 466

  Fly   379 VKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQ--------- 434
            .|......|      ||..|....:|.          .|.|:|:.|:     :||.
Mouse   467 FKSLFLMEE------VHMIKNKPASPH----------IKIEMKNATL-----AWDSSHSSIQNSP 510

  Fly   435 ---------------KKQEKRH-RHIE-------------------------------------- 445
                           ||::.|. :|.|
Mouse   511 KLTPKMKKDKRATRGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHTGSLRLQ 575

  Fly   446 ----DVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLR 506
                ::..:.::.:.|||.|:||:||::|:..|||::.::.||:.|:|..:|..|:.|:|..:||
Mouse   576 RTLYNIDLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLR 640

  Fly   507 DNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADI 571
            |||||.:.:||:||..||..|.|..|:..||..|.|.:||.||:|||||:.|:|||||:|....|
Mouse   641 DNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSI 705

  Fly   572 YLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDAL 636
            |:|||||||:|:||...:.:..:.:.|..|..:.|||::|.|...|.::.::.|.|:.:|.::.|
Mouse   706 YILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEEL 770

  Fly   637 KKLIRFRMSVANDVEVAKLRAMRTDSVYEE----------PEPRKSLSQEEHMDRHEIEQQFKEQ 691
            ..|.....::.|::.:.:...:..:|..|.          |:| .|:.:|:.:...|.:....|:
Mouse   771 MNLNGDYATIFNNLLLGETPPVEINSKKEATGSQKSQDKGPKP-GSVKKEKAVKSEEGQLVQVEE 834

  Fly   692 QQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEE------------ 744
            :..|||....|..|.:..|.||..::|:::|::...|.|....:||.|.....
Mouse   835 KGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNVGSTAFSTWWLSYWIKQGSGNSTVYQGNRSF 899

  Fly   745 -TEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAF 808
             ::..:..|..:|:.:      :|...:...||...:|...|...|||.|.|:||:||:.::|:.
Mouse   900 VSDSMKDNPFMQYYAS------IYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSP 958

  Fly   809 MHFFTLATSGRILNRFSSDVLAIDVNLP-QAMMDSIEFAVNALAV---LAVVSTANIWLLI---P 866
            |.||....:||||||||.|:..:||.|| ||.|    |..|.:.|   :.:::....|.|:   |
Mouse   959 MKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEM----FIQNVILVFFCVGMIAGVFPWFLVAVGP 1019

  Fly   867 ATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDF-HYYQ 930
            ..::.:||:....:.|   |.|||::.|::||..||..::.:|||||.|.|    ..::| |.||
Mouse  1020 LLILFSLLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYN----KRQEFLHRYQ 1077

  Fly   931 ---NENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVL 992
               ::|.:..:|.....|..|...|||.:  .|..|...::...|....|...||||:.:::|..
Mouse  1078 ELLDDNQAPFFLFTCAMRWLAVRLDLISI--ALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTG 1140

  Fly   993 MCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHG 1057
            :.|..:|...|.|...|||||:..|:...|..|....::...|..||..|::.|.:..:||..:.
Mouse  1141 LFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPPHDWPQEGEVTFENAEMRYRENL 1205

  Fly  1058 PYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGH-ISIDGFETSQLGLHDLRRRIS 1121
            |.:||.::|||:.:|||||||.|.:||||:..|||||..::|. |.|||...|.:||.|||.:::
Mouse  1206 PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGIRISDIGLADLRSKLA 1270

  Fly  1122 IIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQ 1186
            ||||:||||||::|.|||||.:.|::::|.|||...:||.::.|...:...:.:.|.|||:|:||
Mouse  1271 IIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQ 1335

  Fly  1187 LVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVD 1251
            |:|:||||||..||||:|||||.:|.|||.||||.|...||.||:||||||||||:.:||:||:.
Mouse  1336 LLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLA 1400

  Fly  1252 MGRVVELGHPHELLHN 1267
            .|:|||...|..||.|
Mouse  1401 QGQVVEFDTPSVLLSN 1416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	435/1380 (32%)
		ABC_membrane	92..358	CDD:294371	65/275 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	84/269 (31%)
		ABC_membrane	762..988	CDD:294371	78/236 (33%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	117/219 (53%)
Abcc5	NP_038818.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		PLN03130	100..1424	CDD:215595	435/1377 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..569		5/67 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650