DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcd2

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_036124.2	Gene:	Abcd2 / 26874	MGIID:	1349467	Length:	741	Species:	Mus musculus

Alignment Length:	814	Identity:	162/814 - (19%)
Similarity:	279/814 - (34%)	Gaps:	256/814 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSK 72
            ::|.|...|.||.:  .:..|:||.                |.|.:|:.
Mouse    74 KKPAPGLNAAFFKQ--LLELRKILF----------------PKLVTTET---------------- 104

  Fly    73 PNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKH------SAYLY 131
                       ||      :....:|:...|...:.:.||       .|||.|.      ..::.
Mouse   105 -----------GW------LCLHSVALISRTFLSIYVAGL-------DGKIVKSIVEKKPRTFII 145

  Fly   132 AMGVVLCSLISGLFFHPFMKYL---FRVGSRVRLA-------CAGLVYRKFLRVSVAADNSGVSG 186
            .:...|...|...|.:..::||   ..:..|.||.       .|...|.|.:.:.....|...|
Mouse   146 KLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFANQTYYKVINMDGRLANPDQS- 209

  Fly   187 YAISLMATDLPTFNESF-YCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLG-TIVAFIPLQAWAA 249
                 :..|:..|::|. :.:..|.:..|:.::..|.:.:.........:| |::|.:.:.|.|.
Mouse   210 -----LTEDIMMFSQSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGPTLLAGLVVYATAK 269

  Fly   250 RAIARYKRSSADVGDERVK------LMNEIIAAMQLIKMYAWEKSFAKLIGKVRKE---EMDSIR 305
            ...|...:..:.|.:|..:      :.:.|||.::.|..|...|...|.:.|..|.   :|:.|.
Mouse   270 VLKACSPKFGSLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKCYKALAYQMNLIL 334

  Fly   306 GSTYIYAGLQCTGMISKLSLFLSLVTYVFT--GDIVTSQKVFIVASYYD-HLNDSLLHSWPLAIN 367
            .....|.      ||.:.     |:.||::  |.|:.:..:.....:.| .|.|.
Mouse   335 SKRLWYI------MIEQF-----LMKYVWSSCGLIMVAIPIITATGFADGDLEDG---------- 378

  Fly   368 MWVETFVVANRVKDFLFQHENPADGG------VHNFKEAEDNPEHGNFFGRTHK---PKAEVKSI 423
              .:..:|::|.:.|.......|.|.      :.::||.   .|...:..|.:.   ...|||.
Mouse   379 --PKQAMVSDRTEAFTTARNLLASGADAIERIMSSYKEI---TELAGYTARVYNMFWVFDEVKR- 437

  Fly   424 TVHKLSASWDQKKQEKRHRHIE--------------DV-----------------------SFQA 451
            .::|.:.:.:.:...||..::|              ||                       :|:.
Mouse   438 GIYKRTVTQEPENHSKRGGNLELPLSDTLAIKGTVIDVDHGIICENVPIITPAGEVVASRLNFKV 502

  Fly   452 QDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVL--------SYAPQEPWLLRGSLRDN 508
            ::...:.|.|..|.|||:|.:::.|...:      ..|||        .|.||.|::..|||||.
Mouse   503 EEGMHLLITGPNGCGKSSLFRILSGLWPV------YEGVLYKPPPQHMFYIPQRPYMSLGSLRDQ 561

  Fly   509 ILFTEPYDEQR---YLE-----VLRVCHLDRDVEQLPLGDSTRVGEGGAS--------LSGGQKA 557
            :::.:..|:.|   |.:     :|...||...|::          |||..        ||||:|.
Mouse   562 VIYPDSADDMREKGYTDQDLERILHSVHLYHIVQR----------EGGWDAVMDWKDVLSGGEKQ 616

  Fly   558 RVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLL 622
            |:.:||..|.|....|||:..|||...|...:....:...:|   .:.:|||..|.::..||:..
Mouse   617 RMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAIGAGIS---LLSITHRPSLWKYHTHLLQF 678

  Fly   623 EGGRISVQG--HYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIE 685
            :|     :|  .::.|...||..:|.                                      |
Mouse   679 DG-----EGGWRFEQLDTAIRLTLSE--------------------------------------E 700

  Fly   686 QQFKEQQQIGSVKL-QTYKEYFKVLGHPLVVVLI 718
            :|..|.|..|..|: |...|..|:||...|:..|
Mouse   701 KQKLESQLAGIPKMQQRLNELCKILGEDSVLKTI 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	162/813 (20%)
		ABC_membrane	92..358	CDD:294371	57/295 (19%)
		ABCC_MRP_domain1	423..626	CDD:213217	62/263 (24%)
		ABC_membrane	762..988	CDD:294371
		ABCC_MRP_domain2	1042..1261	CDD:213211
Abcd2	NP_036124.2	Interaction with PEX19. /evidence=ECO:0000250	1..218		35/207 (17%)
		3a01203	74..686	CDD:273360	145/726 (20%)
		ABC_membrane_2	80..365	CDD:284003	65/359 (18%)
		ABCD_peroxisomal_ALDP	479..684	CDD:213190	57/228 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1117
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860