DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc8

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_037171.2	Gene:	Abcc8 / 25559	RGDID:	3786	Length:	1582	Species:	Rattus norvegicus

Alignment Length:	1416	Identity:	409/1416 - (28%)
Similarity:	671/1416 - (47%)	Gaps:	216/1416 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLES-TQVSSFLLGHWEQELKRSKPN-----V 75
            |..||..:.|....:....::.:|...:.:...::.: |......|....|..|.::..     :
  Rat   223 NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCLAFDAQARKDTQSQQGARAI 287

  Fly    76 LRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVS-------FFSESTGKITKH------- 126
            .|.:..|:|...|.:| .:.|:|..:....||.:.|:|.       .|...|..:..:
  Rat   288 WRALCHAFGRRLVLSS-TFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEF 351

  Fly   127 --SAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSG--VSGY 187
              :||:.|:.:.|..|:...|...........|..:|.|....:|.|.:.:|.:..:.|  .:|.
  Rat   352 LGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQ 416

  Fly   188 AISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAI 252
            ..:|:|.|.......|:....||..|::.:|.|.::|.::|..|::|...|:...|:|.:.|..:
  Rat   417 ICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKL 481

  Fly   253 ARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCT 317
            ::.:||:.:..:||:|..||::..::|:|:||||..|...:.|.|::||.|:|... :|
  Rat   482 SQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLRAFA-VY------ 539

  Fly   318 GMISKLSLFLS--------LVTYV----FTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWV 370
               :.:|:|::        |:|:|    |..:...|..|...:....|:..:.|......:...|
  Rat   540 ---TSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTV 601

  Fly   371 ETFVVANRVKDFLFQHE---------NPADGGVHNFKEAEDNPEHGNF-------FGRTHKPKAE 419
            :..|...::.:||...|         .||..|           :.|.:       ..|....:.|
  Rat   602 KALVSVQKLSEFLSSAEIREEQCAPREPAPQG-----------QAGKYQAVPLKVVNRKRPAREE 655

  Fly   420 VKSI--TVHKLSASWDQKKQEKRHRHI--------------EDVSFQAQDQQFVGIVGTVGAGKS 468
            |:.:  .:.:|:.|.|........:.|              .:::.:....|...|||.||.|||
  Rat   656 VRDLLGPLQRLTPSTDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKS 720

  Fly   469 TLLQVILGELDIISGSVEVN---------------------------GVLSYAPQEPWLLRGSLR 506
            :||...|||:..:||:|..|                           |.::||.|:||||..::.
  Rat   721 SLLLATLGEMQKVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVE 785

  Fly   507 DNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADI 571
            :||.|..|:::|||..|:..|.|..|::.||.||.|::||.|.:|||||:.|:|:|||:|:..::
  Rat   786 ENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNV 850

  Fly   572 YLLDDPLSAVDSHVSKMLLDRCLNEFL--SKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYD 634
            ..||||.||:|.|:|..|:...:.|.|  .|:..:||||::|.|.|.|.::.::.|.|..:|
  Rat   851 VFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG--- 912

  Fly   635 ALKKLIRFRMSVANDVEVAKLRAMRTDSVYEE--------PEPRKSLSQEEH------MDRHEIE 685
            .||.   |:.|.....|..|....|.|...|:        |||.:.|.:...      :|..|.|
  Rat   913 TLKD---FQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEE 974

  Fly   686 QQFKEQQQ---IGSVKLQTYK-------EYFKVLGHPLVVVLILLMF--VVARSSEATMDIFLSK 738
            ::..|.::   :.||..|..|       :|....|   :::|.||:|  ::.......:|.:|:|
  Rat   975 EEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAG---ILLLSLLVFSQLLKHMVLVAIDYWLAK 1036

  Fly   739 W--------------ATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTL-IFYVLRTFGFFMM 788
            |              :..:|...:|             .:....|.:||:| |...|.|......
  Rat  1037 WTDSALVLSPAARNCSLSQECALDQ-------------SVYAMVFTVLCSLGIALCLVTSVTVEW 1088

  Fly   789 T-LRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLP---QAMMDSIEFAVNA 849
            | |:::.|:|..|...:|.|.|.||.....|.||||||||...||.::|   :.:..|....|:|
  Rat  1089 TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSA 1153

  Fly   850 LAVLAVVSTANIWLLIPATVVVALLYGCRCLYIG-----ASRSLKRIETISRSPIYSHTNATFKG 909
            |||::.|:...:..|:|..||        |.:|.     |||.|::::..::.|:.||...|.:|
  Rat  1154 LAVISYVTPVFLVALLPLAVV--------CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEG 1210

  Fly   910 LATIRALN-GTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDL------ICVLYILAVTFSFL 967
            |.||||.. ..::.::...|..:.|.::|:| .:.||    |.::      .||:.|.|.|  .:
  Rat  1211 LTTIRAFRYEARFQQKLLEYTDSNNIASLFL-TAANR----WLEVRMEYIGACVVLIAAAT--SI 1268

  Fly   968 LFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESV 1032
            ....||...:|.|||.:|.::.:.......:|...::|..:.:|:|:...:...:| :||...:.
  Rat  1269 SNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAE-SYEGLLAP 1332

  Fly  1033 NL-PKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH 1096
            :| ||:||..|::..::|.:||.:....:||.:...|...:||||.|.|.:||||...|.||:..
  Rat  1333 SLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVD 1397

  Fly  1097 I-NGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKE 1160
            : .|.|.|||.:.::|.||.||.|:|||.||||||||::||||||.::.:|..||.|||..:||.
  Rat  1398 MFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKL 1462

  Fly  1161 FVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTK 1225
            .|..|..|::..:.:.|.|||.|||||.|||||.:|:..|.|||||||::|..|:|::|:.:.|.
  Rat  1463 VVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTA 1527

  Fly  1226 FAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFV 1276
            ||..||:|||||:||::..|.|||:..|.::|...|.:||..:......||
  Rat  1528 FADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFV 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	407/1406 (29%)
		ABC_membrane	92..358	CDD:294371	69/295 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	81/247 (33%)
		ABC_membrane	762..988	CDD:294371	75/242 (31%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	104/219 (47%)
Abcc8	NP_037171.2	CFTR_protein	223..1582	CDD:273530	409/1416 (29%)
		ABC_membrane	<375..590	CDD:279056	55/224 (25%)
		P-loop_NTPase	679..907	CDD:304359	78/227 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..768		0/26 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..962		5/22 (23%)
		ABC_membrane	1017..1295	CDD:279056	82/305 (27%)
		ABCC_SUR2	1343..1582	CDD:213255	109/236 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740