DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abc2

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_593943.3	Gene:	abc2 / 2543193	PomBaseID:	SPAC3F10.11c	Length:	1478	Species:	Schizosaccharomyces pombe

Alignment Length:	1353	Identity:	422/1353 - (31%)
Similarity:	665/1353 - (49%)	Gaps:	143/1353 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSKP 73
            :|:..|.||.||:..|.|...::..|.:..|..||.:...|:..|:.::.....:|....|:.|.
pombe   188 RPSRFTYANIFSRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFEKNWISHAKKKKS 252

  Fly    74 NVLR--MIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHS-----AYLY 131
            ::..  ::|..: |......||..::...|...||.::..:|.|.|..:   ::|.     .:..
pombe   253 SLYMWGVLFLNH-WKLTVVIIVLKLVQDVVAFIQPNLIRKIVIFVSSYS---SEHPQPPQVGFSL 313

  Fly   132 AMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDL 196
            |:.:.|.:::.......:.:....:|.|.|......:|||.||:|.||..|...|..::.|:.|.
pombe   314 AIAMFLTNVVQTALLQQYFQLGMVLGMRWRSELITAIYRKSLRLSSAARQSRSVGDIVNYMSVDT 378

  Fly   197 PTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSAD 261
            ....:.......:..||.:.|:.:..:|.|:|:.|:.|........|.....|....|::.....
pombe   379 QKVCDLTMFLFVIVSGPFQIVLALTNLYHLVGYGALSGAFVTFLLFPCNVVIASIFKRFQNRQMK 443

  Fly   262 VGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEE----------MDSIRGSTYIYAGLQC 316
            ..|.|.:.|.|||..::.||:||||..|.:.:.::|...          :::|...|:::|.:
pombe   444 NKDARSQFMTEIINNIRSIKLYAWENIFLQKLLQLRNTRELRMLKKIGIVNTIGNFTWLFAPI-- 506

  Fly   317 TGMISKLSLFLSLVTY----VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVAN 377
              ::|..:....:|.|    |.:.||     ||...|.::.|...|. ..|:.::..:|..|..:
pombe   507 --LVSAATFGTFIVLYGKTRVLSVDI-----VFACLSLFNLLQFPLT-MLPIVVSSVLEASVAIS 563

  Fly   378 RVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHR 442
            |:..||...|  .|........|...|..              ..:.:.|.:.||....|.....
pombe   564 RIYGFLTAGE--LDSNAVQRYPANKEPSG--------------VCLEIKKGTFSWSGPGQNAAEP 612

  Fly   443 HIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRD 507
            .:.|:.|.|:..:...|||.||.|||:||:..||.:...||||...|.::||.|:||:|..::::
pombe   613 TLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCGSIAYAAQQPWILNATIQE 677

  Fly   508 NILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIY 572
            ||||....|.:.|.:.:|.|.|.||.|.|..||.|.|||.|.|||||||||:|||||||.::|||
pombe   678 NILFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGISLSGGQKARISLARAVYSRSDIY 742

  Fly   573 LLDDPLSAVDSHVSKMLLDRCLNE--FLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDA 635
            ||||.|||||.||::.|:...|..  .|..:..||.|:.:.:|:....:.:|..|:|...|.:..
pombe   743 LLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILSTNSLTVLKEASMIYMLRNGKIIESGSFTQ 807

  Fly   636 L----------------KK-----------LIRFRMSVANDVEVAKLRAMRTDSVYEEPEP---- 669
            |                ||           |.|.:..:.:..:|....:..:|:|...|:.
pombe   808 LSSSPDSQLFQLLSEFSKKDTASSTGADTPLSRSQSVITSSTDVTSSASRSSDTVSNYPKATIKG 872

  Fly   670 ----RKSLSQEEHMDRHEIEQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEA 730
                ||.|:.|:::   :...|..|:.:.|.||.:.|..|||...  |.::.:..:|::....
pombe   873 TGRIRKRLTDEDNV---KATGQAAEKMERGKVKWKVYWTYFKACS--LFLIFLYFLFIIGGIG-- 930

  Fly   731 TMDIFLSKWAT-WEETEPN-QHEPIPEYHRTRLRMMILYTF--LILCTLIFYVLRTFGFFMMTLR 791
             |::..:.|.. |.|.... .:.|.|.::      :.:||.  |:.|.||.....|...| ..::
pombe   931 -MNVGTNVWLKHWSEVNTQLGYNPKPYFY------LGIYTLFGLLSCALISLSSLTITVF-CAIK 987

  Fly   792 ISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVV 856
            ....:||.:.:.|:||.|.||....:|||||||||||..:|..:.:..|.........:.||||:
pombe   988 SCRYLHDSMVKAVLRAPMSFFETTPTGRILNRFSSDVYRVDEVISRVFMFFFRNLFQIVFVLAVI 1052

  Fly   857 STANIWLLIPATVVVALLYGCR---CLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRA--L 916
            ..::...:|   ::|.|.:..|   ..|...||.|||:::::|||:|:|...:..||:||||  :
pombe  1053 CYSSPMFMI---LIVPLFFLYRYNQVYYTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDM 1114

  Fly   917 NGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVG 981
            ..|...|.|...  :.|....:|:.|.||..|...:.|..|.:.:..|..:|........||.||
pombe  1115 EDTFISENDIRV--DTNHRIWFLYFSSNRWQAIRVEAIGALVVFSSAFFGVLSAVRGNPNSGLVG 1177

  Fly   982 LA------ITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSE-PAYETEESVNLPKH-- 1037
            |:      ||||:..|      :||:|::|..:.||||::||:.:||| |:.       :|.|
pombe  1178 LSLSYAVQITQSLTFV------VRQSVDVETNIVSVERMLEYIGLPSEAPSI-------IPDHRP 1229

  Fly  1038 ---WPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-IN 1098
               |||.|.:.|....:||..:.|.:|..::..|:.:|||||||.|.||||::..|||||.. .:
pombe  1230 PEGWPSHGAIKFDHYSVRYRENLPLVLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTS 1294

  Fly  1099 GHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVS 1163
            |.|.:|....:.:||||||.|::||||:...|.|::|.||||....||||:|.||||..||:|:.
pombe  1295 GDIQLDDINITSIGLHDLRSRLAIIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQ 1359

  Fly  1164 NLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAH 1228
            .|..|:..|:.:.|||.|.|||||:||.||||...::|::|||||.||.|||.::|..|..:|..
pombe  1360 TLDGGLYSRVTEGGANLSSGQRQLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFND 1424

  Fly  1229 CTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGV 1281
            .|:||||||::||||::|::|:|.|:|||.....:||.|:....:...:::|:
pombe  1425 RTILTIAHRINTVMDSNRILVLDHGKVVEFDSTKKLLENKASLFYSLAKESGL 1477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	420/1338 (31%)
		ABC_membrane	92..358	CDD:294371	64/284 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	88/204 (43%)
		ABC_membrane	762..988	CDD:294371	75/238 (32%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	107/219 (49%)
abc2	NP_593943.3	MRP_assoc_pro	96..1477	CDD:188098	421/1351 (31%)
		ABC_membrane	272..545	CDD:279056	64/284 (23%)
		ABCC_MRP_domain1	593..798	CDD:213217	88/204 (43%)
		ABC_membrane	928..1190	CDD:279056	81/276 (29%)
		ABCC_MRP_domain2	1237..1456	CDD:213211	107/218 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710