DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ybt1

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_594585.1	Gene:	ybt1 / 2542640	PomBaseID:	SPAC9E9.12c	Length:	1427	Species:	Schizosaccharomyces pombe

Alignment Length:	1335	Identity:	372/1335 - (27%)
Similarity:	640/1335 - (47%)	Gaps:	180/1335 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QPNPVTKANFFSKWF-FIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRS- 71
            :|:|....:.||..| :.|...|:.|..::.:..:|:    |:|..|:.:......:.:..::|
pombe   190 RPSPEQTCSIFSLIFTYGWLNGIIWKSWKKPITLTDV----PALPDTECTQIWYSRFAKNDRKSL 250

  Fly    72 --------KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSA 128
                    |..:|.|:|             .|::..:.....||.:..|:.:. ::......:|.
pombe   251 MHTILLSLKSTILLMVF-------------LSVLVSSTLFVTPLAIKKLLQYL-QNPKSDEGNSP 301

  Fly   129 YLYA----MGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFL---RVSVAADNSGVS- 185
            :|:.    :|..|.|::..|:.|...:::.    |::.|...::|:|.|   .:.||.|.|.::
pombe   302 FLWVFVLLIGPYLASVVKELYVHVSRRFML----RIKAAITQMIYKKVLTSKTLFVAVDGSKINL 362

  Fly   186 GYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAAR 250
            .|..:|:|.|:....|.......:.|.|||..|.:|.:|||:||.|.|||...:.........|.
pombe   363 DYVYNLLAKDVDNIGEMREFIGIIARAPLEMGVSMYFLYQLLGWSAYVGLLLAILSSSFPLLVAS 427

  Fly   251 AIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQ 315
            .|:|....:....|||::|..|::.::::.|::.||:.....|.:.|..|::::...| ::..:.
pombe   428 KISRLTSIANTSSDERIRLTTELLKSIKITKLFGWERPMLSRIQEKRSFEVNNMYSLT-LFDIIF 491

  Fly   316 CTGMISKLSLFLSL-VTY-VFT---GDIVTSQKVFIVASYYDHLNDSLLHSWPLAIN-MWVETFV 374
            .:||  |::.|:|: :|: ::|   |..:|....|...|.:..|....:  |..::: .:::..|
pombe   492 KSGM--KIAPFISMFITFAIYTKIMGHQLTPATAFTSISMFGLLRYQFI--WLASVSRQFIQFKV 552

  Fly   375 VANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEK 439
            ...||.:|::       |.:.|....|.:                 .|......|.||.......
pombe   553 SLKRVDNFVY-------GNMVNDSSIESS-----------------DSFVFENTSLSWSPTPSTA 593

  Fly   440 RHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGV---LSYAPQEPWLL 501
            ..: :::::|.....||..:||:.|:|||||...:||||.:|||.:....:   ::|.||..||.
pombe   594 LFQ-LKNLNFTIPRNQFTLVVGSTGSGKSTLAMALLGELHVISGKMTTPSISQRIAYVPQAAWLR 657

  Fly   502 RGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVY 566
            .|::|.||||.|||||:||.::::.|.||.|:..:..||.|.:...|:|||||||.|||||||:|
pombe   658 NGTIRSNILFGEPYDEERYFQIIKACCLDSDLNSMNDGDLTYIHSNGSSLSGGQKQRVSLARALY 722

  Fly   567 RKADIYLLDDPLSAVDSHVSKMLLDRC-LNEFLSKKIRILVTHRVQL-LRHVDHLVLLEGGRISV 629
            ..|::|:.||..||:|...|:.:.:.| |:..|..|..||.||.|.| |...:::::|:.....:
pombe   723 SNAEVYIFDDIFSALDVSTSRKIYESCFLSTLLQHKTIILFTHNVSLCLPIAENVIVLKNSTAQL 787

  Fly   630 QGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEI---------- 684
            ... |::::|:                    .|.:.....:|...:||:::.|..
pombe   788 VSP-DSIQELV--------------------PSTFFSSNTKKDNIEEENLEPHSFSFDSTLASSS 831

  Fly   685 ----EQQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEET 745
                ::.|.....|..:.|    .|.|..|....::..:|:.::::.|.|::..:::.|:
pombe   832 DNDEQRDFASNSSIVLLGL----HYLKYFGSNKYILGSILLVMMSQVSLASIHFWIALWS----- 887

  Fly   746 EPNQHEPIPEYHRTRLRMMILYTFLILCTLIF---YVLRTFGFFMMTL-----------RISLRI 796
             .|.                |::..:..:..|   |.:..|.:|:|.|           ..|..|
pombe   888 -GNS----------------LFSLKLPSSFSFLWGYAILLFIYFLMDLSRAITFAKGGRTASENI 935

  Fly   797 HDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVST-AN 860
            ||.|.:.|:.:.:|:|....:||||||||.|:.|.| ||..|.::.:     .|.|:|::.| .|
pombe   936 HDILSERVLYSPLHWFEKTAAGRILNRFSKDMYATD-NLLWASLEGM-----LLCVMAILITMLN 994

  Fly   861 IWL-----LIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTK 920
            :.|     ::||..|..|:|.....|..|.:.|..:::...||:::....|..|:..|||....|
pombe   995 VTLVMPIFMVPAAFVSLLVYLHGYAYSKAQKQLTSLQSSRTSPVFTMLGETLGGITVIRAFKKEK 1059

  Fly   921 YMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAIT 985
            ..|.:...:.::....||:..:|||..|..||.|..|...:.....||   .:....|.||.::.
pombe  1060 IFEHENMAFIDDMIQPLYISFAINRWLAIRTDGISGLVGFSTGLIALL---RQNIPPGLVGFSLN 1121

  Fly   986 QSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLR 1050
            .::...:.....:|...|:...:.:..|:.||:.:|||....:..:..:.|.||:.|.:..::|.
pombe  1122 SAIGFNISVLVFVRANNEILTYINNFRRLYEYMLLPSEKNESSCLTKPMNKEWPTLGHVSIKNLT 1186

  Fly  1051 LRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHI-NGHISIDGFETSQLGLH 1114
            :.||.....:|:.:...|..:|||.|||.|.:|||::...|.|...| :|.:.:||.:.:.|.|.
pombe  1187 VSYSIGQAAVLEDINLEILPKEKIAIVGRTGSGKSTMGLTLLRFTMIMSGAVEVDGIDINSLDLE 1251

  Fly  1115 DLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFV----SNLKDG----INC 1171
            .||:|||:|||||||.||::|.|||||||..|.||...|:....:..|    .|..|.    ::.
pombe  1252 VLRQRISLIPQDPVLISGTVRSNLDPFEEYGDGELNEILKTASCESLVQASNKNSLDAFAIHLDT 1316

  Fly  1172 RLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAH 1236
            .:...|.|||.||||::.|||||:|:::|:|:||:||:||..||..||:.:...|.|.|||.|||
pombe  1317 PVDSGGVNFSSGQRQILALARALVRKSRIVILDESTASVDDTTDRRIQQMLRAAFKHATVLCIAH 1381

  Fly  1237 RLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGY 1271
            |:.|::|.|:|:|:|.|:.||.|.|..|...|..:
pombe  1382 RIKTIVDYDKVLVLDSGKTVEFGSPKSLYTQRRAF 1416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	371/1330 (28%)
		ABC_membrane	92..358	CDD:294371	67/278 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	82/207 (40%)
		ABC_membrane	762..988	CDD:294371	67/245 (27%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	98/227 (43%)
ybt1	NP_594585.1	CFTR_protein	192..1416	CDD:273530	371/1331 (28%)
		ABC_membrane	266..537	CDD:294371	68/291 (23%)
		ABCC_MRP_domain1	577..782	CDD:213217	82/205 (40%)
		ABC_membrane	866..1094	CDD:294371	65/255 (25%)
		ABCC_MRP_domain2	1178..1406	CDD:213211	98/227 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900