DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abc3

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_595055.1	Gene:	abc3 / 2540937	PomBaseID:	SPBC359.05	Length:	1465	Species:	Schizosaccharomyces pombe

Alignment Length:	1345	Identity:	413/1345 - (30%)
Similarity:	670/1345 - (49%)	Gaps:	122/1345 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGH---WEQELKR 70
            :|:.|..||.|||..|.|....:..|....|..||::...|...|   .:.::|.   |....|.
pombe   170 RPSEVRYANIFSKLSFSWISSFIKFGYTNYLKESDVWLLPPDERS---GNLIIGFEDWWIYHSKN 231

  Fly    71 SKPNVL--RMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSA--YLY 131
            .:.::.  :::|..: |..|....:..::...:...||.::...:.|.|..|....:..:  ::.
pombe   232 KRRSLFLWKLLFFNH-WKLVALITITKLIQDVLAFVQPTLIQKTILFISSYTSPNPESPSRGFII 295

  Fly   132 AMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDL 196
            |:.|::.:.:..|....:.:.:..:|.|.:......:|||.|.:|.:|..:...|..|:.||.|.
pombe   296 AILVLVANFLQTLLLQQYNQLIMLLGMRWKTELLASIYRKSLLLSSSARQNRSIGDIINYMAVDT 360

  Fly   197 PTFNE-SFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSA 260
            ...:: ..|.| .:..||.:..:.:..:|.|:|:.|..|:...|...|.....|....:::....
pombe   361 QKISDLPIYLF-IIVSGPFQIALALSNLYHLMGYSAFTGVAASVILFPCNIIVANVYKKFQSILM 424

  Fly   261 DVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRK-EEMDSIRGSTYI-----YAGLQCTGM 319
            ...|.|.|||.|||..::.||:||||..|.:.:..:|. :|:..::...:|     :|.:..|.:
pombe   425 KNKDSRSKLMTEIINNIRSIKLYAWETPFLQKLLHIRNTKELSMLKKIGFITAIGDFAWIFTTII 489

  Fly   320 ISKLSLFLSLV----TYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVK 380
            ::.::....::    |...|.||     ||...|.::.|...|. ..|..|:..:|..|..:|:.
pombe   490 VTTVAFGAFIIFHGKTQALTADI-----VFPAVSLFNLLQFPLA-MLPTVISSLLEASVSVSRIY 548

  Fly   381 DFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQK--KQEKRHRH 443
            :||...|...: ||..|...|          ..|:...|:||.|.     ||.:|  ||:....
pombe   549 EFLIAQELDYN-GVQRFPATE----------IPHEICLEIKSGTF-----SWSKKTLKQQVTPT- 596

  Fly   444 IEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDN 508
            :..::|.|::.:...|.|.||||||:||:..:|.:...||||...|.|:||.|:||:...::|:|
pombe   597 LRQINFVAKNGELTCIFGKVGAGKSSLLEACMGNMYKNSGSVFQCGSLAYAAQQPWIFDATIREN 661

  Fly   509 ILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYL 573
            |||...:|.:.|.:.:..|.|.||.|....||.|.||:.|||||||||:|:|||||:|.:|||||
pombe   662 ILFGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLSGGQKSRISLARAIYSQADIYL 726

  Fly   574 LDDPLSAVDSHVSKMLLDRCLNE--FLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDAL 636
            |||.||:||.|||:.|:......  ||.....:|.|:.:.:|:..|.:.:|..|:|..:|:|:.|
pombe   727 LDDVLSSVDQHVSRDLIKNLFGPEGFLRTHCVVLTTNSLNVLKEADSIYILSNGKIVEKGNYEHL 791

  Fly   637 ---------KKLIRF-------------------RMSVANDVEVAKLRAMRTDSVYEEPEPRKSL 673
                     ::|..|                   ::|:|..:.|..|      ..|...|.:.|.
pombe   792 FVSTNSELKQQLSEFNDEKDTQPLPEHTTSYPSTQISLAPSIHVEGL------ETYSSSERKDSS 850

  Fly   674 SQEEHMDRHEIEQQFKEQQ------------QIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVA- 725
            ::.:...|:.|.|:..|..            |.|.||...|..|||...  :.::|:...|:::
pombe   851 NKYKSRKRNPIRQKVTEDDKGKCVAQTDELVQRGKVKWHVYWMYFKSCS--IGLILLYFFFIISG 913

  Fly   726 -RSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMT 789
             ..:.|| :::|..|:.......::..|.|.::   |.:.:.:.|| .|..|     :.....||
pombe   914 IMMNVAT-NVWLKHWSEENGKSSSELNPSPYFY---LGIYLFFGFL-SCAFI-----SSSSLTMT 968

  Fly   790 LRISLR----IHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNAL 850
            :...:|    :||.:.:.::||.|.||...:|||||||||:||..:|..:....|.....::..|
pombe   969 VLCGIRSGRYLHDSMLKTILRAPMGFFETTSSGRILNRFSNDVYKVDEVVSLTFMFFFRNSIQVL 1033

  Fly   851 AVLAVVS-TANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIR 914
            .:|.|:. :|.:.||:...:....||. |..|:..||.|||::.::|||:|:|...:..||:|||
pombe  1034 FILGVICYSAPLSLLLIVPLFFLYLYN-RAYYVRTSRELKRLDNVTRSPLYAHVQESLSGLSTIR 1097

  Fly   915 A--LNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYS 977
            |  :..|...|.|...  :.|....::..|.:|..|...:.|..|.|....|..:|.........
pombe  1098 AYGMQETFVEENDLRI--DTNHRVWFMFFSSSRWQAIRVECIGDLIIFCTAFYGILSAIKGSPNP 1160

  Fly   978 GDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGG 1042
            |.||.:::.::::.......::|:|:.||...||||::||:|:.|| |.|.......|..||:.|
pombe  1161 GLVGFSLSYAIQITQGLSFIVQQSVDAENNTVSVERILEYINVKSE-APEIIPENRPPCEWPTDG 1224

  Fly  1043 QLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGF 1106
            .:.|.....:|.....:.|..:...|...|||||||.|.||||::..||||:.. ..|.|.||..
pombe  1225 AVSFNHYSAKYREDLSFALNNINIEISPREKIGIVGRTGAGKSTLAMALFRIIEPTEGKIEIDNE 1289

  Fly  1107 ETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINC 1171
            :.::.||:|||.|:|||||:..:|.|::|.||||....||:::|..||...||..:|.|:||:..
pombe  1290 DITKFGLYDLRSRLSIIPQESQIFEGNIRENLDPNHRLTDKKIWEVLEIASLKNCISQLEDGLYS 1354

  Fly  1172 RLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAH 1236
            |:.:.|||||.|||||:||||.||...:||::|||||:|..|||.::|:.|..:|...|:||:||
pombe  1355 RVAEGGANFSSGQRQLICLARVLLTSTRILLLDEATASVHAETDAIVQQTIRKRFKDRTILTVAH 1419

  Fly  1237 RLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGV 1281
            |::||||:||::|:|.|:|||.....:||.|:....:...:::|:
pombe  1420 RINTVMDSDRILVLDHGKVVEFDATKKLLENKDSMFYSLAKESGL 1464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	411/1330 (31%)
		ABC_membrane	92..358	CDD:294371	61/278 (22%)
		ABCC_MRP_domain1	423..626	CDD:213217	86/206 (42%)
		ABC_membrane	762..988	CDD:294371	68/232 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	103/219 (47%)
abc3	NP_595055.1	MRP_assoc_pro	101..1464	CDD:188098	412/1343 (31%)
		ABC_membrane	254..527	CDD:294371	61/278 (22%)
		ABCC_MRP_domain1	575..781	CDD:213217	89/211 (42%)
		ABC_membrane	907..1177	CDD:279056	76/282 (27%)
		ABCC_MRP_domain2	1224..1443	CDD:213211	103/218 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	170	1.000	Domainoid score	I894
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710