DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcb4

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_036822.1	Gene:	Abcb4 / 24891	RGDID:	620248	Length:	1278	Species:	Rattus norvegicus

Alignment Length:	1368	Identity:	297/1368 - (21%)
Similarity:	553/1368 - (40%)	Gaps:	297/1368 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KRSKPNVL--RMIFKAYGWSFVPASIVYSIMAIAVHTTQPLML---GGLVSFFSESTG------- 121
            |:.|.|::  ..:|:...|......::.:.||||..:..|||:   |.:...|.::.|
  Rat    30 KKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKFVDNAGNFSLPVN 94

  Fly   122 --------------KITKHSAYLYAM--GVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYR 170
                          ::|:::.|...:  ||:|.:.|...|      :....|.::|     .:.:
  Rat    95 FSLSMLNPGRILEEEMTRYAYYYSGLGGGVLLAAYIQVSF------WTLAAGRQIR-----KIRQ 148

  Fly   171 KF-------------------LRVSVAADNSGVS---GYAISLMATDLPTFNESFYCFHELWRGP 213
            ||                   |...:..|.|.:|   |..:.:....:.||...|..      |.
  Rat   149 KFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAIATFFAGFIV------GF 207

  Fly   214 LEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIA--- 275
            :.|.....:|..:   .|::||.|.|....|..::.:.:|.|.::.| |.:|.:..:..:||
  Rat   208 IRGWKLTLVIMAI---TAILGLSTAVWAKILSTFSDKELAAYAKAGA-VAEEALGAIRTVIAFGG 268

  Fly   276 AMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLSLVTYVFTGDIVT 340
            ..:.::.|......||.|| ::|..      |..|..|      |:.|.::.|.....:.|..:.
  Rat   269 QNKELERYQKHLENAKKIG-IKKAI------SANISMG------IAFLLIYASYALAFWYGSTLV 320

  Fly   341 SQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEA----- 400
            ..|.:.:.:               |:.::....:.|     |......|......|.:.|
  Rat   321 ISKEYTIGN---------------AMTVFFSILIGA-----FSVGQAAPCIDAFPNARGAAYVIF 365

  Fly   401 ---EDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGT 462
               ::||:..:|..|.|||.:...::....:..|:..:...|   .::.::.:.:..|.|.:||.
  Rat   366 DIIDNNPKIDSFSERGHKPDSIKGNLEFSDVHFSYPSRANIK---ILKGLNLKVKSGQTVALVGN 427

  Fly   463 VGAGKSTLLQVILGELDIISGSVEVNG-------------VLSYAPQEPWLLRGSLRDNILF--- 511
            .|.||||.:|::....|...|::.::|             .:....|||.|...::.:||.:
  Rat   428 SGCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRG 492

  Fly   512 TEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDD 576
            ....||.:  :.::..:....:.:||....|.||:.||.||||||.|:::|||:.|...|.|||:
  Rat   493 NVTMDEIK--KAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDE 555

  Fly   577 PLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQG-HYDALKKL- 639
            ..||:|:. |:..:...|::....:..|::.||:..:|:.|.:...|.|.|..|| |.:.:||.
  Rat   556 ATSALDTE-SEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEG 619

  Fly   640 IRFR-----------MSVANDVEVA-------------KLRAMRTDSVYEEPEPRKSL-SQEEHM 679
            |.||           :|...:||::             |.|..|..:       :||| |...|.
  Rat   620 IYFRLVNMQTSGSQILSEEFEVELSDEKAAGGVAPNGWKARIFRNST-------KKSLKSSRAHQ 677

  Fly   680 DRHEIEQQFKEQQ--QIGSVKL----QTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSK 738
            :|.::|....:..  .:..:|:    :|...|| |:|        .|..:...:.:....|.||:
  Rat   678 NRLDVETNELDANVPPVSFLKVLRLNKTEWPYF-VVG--------TLCAIANGALQPAFSIILSE 733

  Fly   739 ----WATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLR-------- 791
                :...::|...|          :..|.         :|:|..|....||...|:
  Rat   734 MIAIFGPGDDTVKQQ----------KCNMF---------SLVFLGLGVHSFFTFFLQGFTFGKAG 779

  Fly   792 --ISLRIHDQLFQGVIRAFMHFFT--LATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAV 852
              ::.|:....|:.::|..|.:|.  ..::|.:..|.::|..            .::.|......
  Rat   780 EILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA------------QVQGATGTRLA 832

  Fly   853 LAVVSTANI-----------W------LLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIY 900
            |...:|||:           |      |.:...:.||.:...:.|...|.|..|.:|...:.
  Rat   833 LIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKI--- 894

  Fly   901 SHTNATFKGLATIRALNGTK-----YMERDFHYYQNENTSA-LY-LHVSINRAFAFWTDLICVLY 958
              .....:.:.|:.:|...:     |:|:....|:|....| :| :..||::||.:::...|..:
  Rat   895 --ATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRF 957

  Fly   959 ILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSE 1023
                 .|:|:.:.|..:            ..::|:..|.:...|.|.:..:...   :|......
  Rat   958 -----GSYLIVNGHMRF------------KDVILVFSAIVLGAVALGHASSFAP---DYAKAKLS 1002

  Fly  1024 PAY-----ETE---ESVNLPKHWPS--GGQLDFRDLRLRYSNHGPY-ILKGLTFTIRGEEKIGIV 1077
            .||     |.:   :|.:....||.  .|.:.|.::...|...... :|:||:..::..:.:.:|
  Rat  1003 AAYLFSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1067

  Fly  1078 GHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNL--- 1138
            |.:..|||::|..|.|... :.|.:.:||.|..:|.:..||.::.|:.|:|:||..|:..|:
  Rat  1068 GSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYG 1132

  Fly  1139 DPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIM 1203
            |.....:.:|:..|.:...:..|:..|......|:.|.|...|.||:|.:.:||||:||.::|::
  Rat  1133 DNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLL 1197

  Fly  1204 DEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNR 1268
            ||||:.:|.|::.::|||:.......|.:.|||||.|:.:.|.::|:|.|:|.|.|...:||..:
  Rat  1198 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQK 1262

  Fly  1269 HGY 1271
            ..|
  Rat  1263 GIY 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	296/1363 (22%)
		ABC_membrane	92..358	CDD:294371	59/316 (19%)
		ABCC_MRP_domain1	423..626	CDD:213217	56/218 (26%)
		ABC_membrane	762..988	CDD:294371	45/261 (17%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	70/223 (31%)
Abcb4	NP_036822.1	PTZ00265	29..1271	CDD:240339	297/1368 (22%)
		ABC_membrane	58..342	CDD:279056	61/337 (18%)
		ABC_MTABC3_MDL1_MDL2	392..628	CDD:213216	66/241 (27%)
		Interaction with HAX1. /evidence=ECO:0000269\|PubMed:15159385	622..646		5/23 (22%)
		ABC_membrane	714..984	CDD:279056	53/322 (16%)
		ABC_MTABC3_MDL1_MDL2	1033..1272	CDD:213216	72/233 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000