DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc1

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_071617.2	Gene:	Abcc1 / 24565	RGDID:	3112	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	1389	Identity:	455/1389 - (32%)
Similarity:	710/1389 - (51%)	Gaps:	175/1389 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RQPNPV--TKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKR 70
            |.|||.  :.|:|.|:..|.|...::|:|.::.|..|||:.......|.:|...|:.:|::|..:
  Rat   203 RDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVK 267

  Fly    71 SK------------------------------------------PNVLRMIFKAYGWSFVPASIV 93
            |:                                          |::.::::|.:|..|: .|.:
  Rat   268 SRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFL-MSFL 331

  Fly    94 YSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGS 158
            |..:...:....|.:|..:::|.::.  :......|||...:.:.:.:..|..|.:....|..|.
  Rat   332 YKALHDLMMFAGPEILELIINFVNDR--EAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGM 394

  Fly   159 RVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYII 223
            |::.|..|.||||.|.::.:|..|...|..::||:.|...|.:.....:.:|..||:..:.:|.:
  Rat   395 RIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFL 459

  Fly   224 YQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKS 288
            :..:|...:.|:..::..:|..|..|.....|:.:.....|.|:||||||:..::::|:||||.:
  Rat   460 WLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELA 524

  Fly   289 FAKLIGKVRKEEMDSIRGSTYIYA----GLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVAS 349
            |...:..:|:||:..::.|.|:.|    ...||..:..||.|...|| |...:|:.::|.|:..:
  Rat   525 FQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT-VDEKNILDAKKAFVSLA 588

  Fly   350 YYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAE-DNPEHGNFFGRT 413
            .::.|... |:..|:.|:..|:..|...|::.|| .||           |.| |:.|..:.
  Rat   589 LFNILRFP-LNILPMVISSIVQASVSLKRLRIFL-SHE-----------ELEPDSIERWSI---- 636

  Fly   414 HKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGEL 478
             |....:.||||...:.:|.:.:...    :..::|...|...|.:||.||.|||:||..:|.|:
  Rat   637 -KDGGGMNSITVKNATFTWARDEPPT----LNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEM 696

  Fly   479 DIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTR 543
            |.:.|.|.:.|.::|.||:.|:...|||:||||..|..|..|..|:..|.|..|:|.||.||.|.
  Rat   697 DKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTE 761

  Fly   544 VGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE--FLSKKIRILV 606
            :||.|.:||||||.|||||||||..:|||||||||||||:||.|.:.::.:..  .|..|.||||
  Rat   762 IGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILV 826

  Fly   607 THRVQLLRHVDHLVLLEGGRISVQGHYD-------ALKKLIRFRMSVANDVEVAKLRAMRTDS-- 662
            ||.:..|..||.::::.||:||..|.|.       |..:.:|...:...|:      |...||
  Rat   827 THGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDL------ASEDDSKN 885

  Fly   663 ----VYEEPEPRKS------------------------LSQEEHMDRHEI------EQQFK---- 689
                :.:|.:|.::                        ::.::|....|:      |:.:|
  Rat   886 GVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEA 950

  Fly   690 EQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWA----TWEETEPNQH 750
            ::.|.|.|||..|..|.|.:| ..:..|.:.:|:....|....:.:||.|.    ....|:.|::
  Rat   951 DKAQTGQVKLSVYWNYMKAIG-LCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGTQENRN 1014

  Fly   751 EPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMT----LRISLRIHDQLFQGVIRAFMHF 811
                      .|:.:.....||     ..:..||:.|..    :..|.|:|..|.|.|:|:.|.|
  Rat  1015 ----------FRLSVYGALGIL-----QGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSF 1064

  Fly   812 FTLATSGRILNRFSSDVLAIDVNLPQAM---MDSIEFAVNALAVLAVVSTANIWLLIPATVVVAL 873
            |....||.::||||.::..:|..:||.:   |.|: |:|....::.:::|....::||...:|
  Rat  1065 FERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSL-FSVIGAVIIILLATPIAAVIIPPLGLV-- 1126

  Fly   874 LYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALY 938
            .:..:..|:.:||.|||:|::||||:|||.|.|..|::.|||....:...|......:||..|.|
  Rat  1127 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYY 1191

  Fly   939 LHVSINRAFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQT 1001
            ..:..||..|...:.:  |::...|:   |.:..:| ...:|.|||:::.|:::.......:|.:
  Rat  1192 PSIVANRWLAVRLECVGNCIVLFAAL---FAVISRH-SLSAGLVGLSVSYSLQITAYLNWLVRMS 1252

  Fly  1002 VELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTF 1066
            .|:|..:.:|||:.||.....|.:::.:|:.. |..||..|:::|||..|||......:||.:..
  Rat  1253 SEMETNIVAVERLKEYSETEKEASWQIQETAP-PSTWPHSGRVEFRDYCLRYREDLDLVLKHINV 1316

  Fly  1067 TIRGEEKIGIVGHTAAGKSSIVHALFRL-AHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLF 1130
            ||.|.||:||||.|.|||||:...|||: ....|.|.|||...:::|||:||.:|:|||||||||
  Rat  1317 TIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLF 1381

  Fly  1131 SGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDC---GANFSMGQRQLVCLAR 1192
            |||||.|||||.:.:|||:|:|||...||.|||.|.|.:|   |:|   |.|.|:||||||||||
  Rat  1382 SGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLN---HECAEGGENLSVGQRQLVCLAR 1443

  Fly  1193 ALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVE 1257
            ||||:.|||::|||||.||.|||:|||..|.|:|...|||||||||:|:||..||:|:|.|.:.|
  Rat  1444 ALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRE 1508

  Fly  1258 LGHPHELLHNRHGYLHRFVEKTGV 1281
            .|.|.|||..| |..:...:..|:
  Rat  1509 CGAPSELLQQR-GVFYSMAKDAGL 1531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	451/1373 (33%)
		ABC_membrane	92..358	CDD:294371	68/269 (25%)
		ABCC_MRP_domain1	423..626	CDD:213217	92/204 (45%)
		ABC_membrane	762..988	CDD:294371	69/234 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	129/222 (58%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	454/1387 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650