DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc12

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_766500.3	Gene:	Abcc12 / 244562	MGIID:	2441679	Length:	1366	Species:	Mus musculus

Alignment Length:	1372	Identity:	424/1372 - (30%)
Similarity:	696/1372 - (50%)	Gaps:	183/1372 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSS--FLLGHWEQELKR-- 70
            ||||..|...|...|.|...::::..:..|....|....| .:|:.:::  |.: .||:|:||
Mouse    43 PNPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSP-YDSSDINAKRFQI-LWEEEIKRVG 105

  Fly    71 -SKPNVLRMIFKAYGWSF----VPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYL 130
             .|.::.|::     |.|    |...:|.:|:.|.:....|.:|      ..:....||..|:..
Mouse   106 PEKASLGRVV-----WKFQRTRVLMDVVANILCIVMAALGPTVL------IHQILQHITSISSGH 159

  Fly   131 YAMGVVLCSLISGLFFHPFMKYLF---------RVGSRVRLACAGLVYRKFLRVSVAADNSGVSG 186
            ..:|:.||   ..||...|.|.||         |...|:::|.:.|::...|........|  :|
Mouse   160 IGIGICLC---LALFTTEFTKVLFWALAWAINYRTAIRLKVALSTLIFENLLSFKTLTHIS--AG 219

  Fly   187 YAISLMATD-LPTFNESFYCFHELWRGPLEGVVFVYII------YQLIGWPAVVGLGTIVAFIPL 244
            ..::::::| ...|..:.:|       ||...:.:.::      :.::|..|:||:...:.|||:
Mouse   220 EVLNILSSDSYSLFEAALFC-------PLPATIPILMVVCAVYAFFILGSTALVGISVYLIFIPI 277

  Fly   245 QAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTY 309
            |.:.|:..:.::||:..|.|:||:.|||.:..::||||||||:||...|..:||.|...:..:.|
Mouse   278 QMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEESFINTIHDIRKREKKLLEKAGY 342

  Fly   310 IYAGLQCTG-MISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETF 373
            :.:|..... ::|.:::..:...::|....:|:...|.|.:.::.:..|:. ..|.::....|..
Mouse   343 VQSGNSALAPIVSTIAIVSTFTCHIFLKRKLTAPVAFSVIAMFNVMKFSIA-ILPFSVKAVAEAS 406

  Fly   374 VVANRVKDFLFQHENPADGGVHNFKEAEDNPE------------HGNFFGRTHKPKAEVKSITVH 426
            |...|:|..|.....|      ::....::|:            ......::..|||:::...|.
Mouse   407 VSLRRMKKILIAKSPP------SYITQPEDPDTILLLANATLTWEQEINRKSDPPKAQIQKRHVF 465

  Fly   427 K-----------------LSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVI 474
            |                 .|..| |....|...|  ::||..:..:.:||.|.||:|||:|:..:
Mouse   466 KKQRPELYSEQSRSDQGVASPEW-QSGSPKSVLH--NISFVVRKGKVLGICGNVGSGKSSLISAL 527

  Fly   475 LGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLG 539
            ||::.:..|.|.|||.|:|..|:.|:..|::|:||||.|.|:.|||...:.||.|.:|:..||.|
Mouse   528 LGQMQLQKGVVAVNGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYG 592

  Fly   540 DSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRI 604
            |.|.:||.|.:|||||:.|:|||||||....:|||||||||||:||.|.:.:.|:.:.|..|..:
Mouse   593 DLTEIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLKGKTVV 657

  Fly   605 LVTHRVQLLRHVDHLVLLEGGRISVQG-HYDALKKLIRFRMSVAN-------DVE----VAKLRA 657
            ||||::|.|...|.::|||.|.|..:| |.:.:::..|:...:.|       |.|    ||.:..
Mouse   658 LVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHIYNVAMVET 722

  Fly   658 MR-------TDSVY---EEPEPRKSLSQEEHMD----RHEIEQQFKEQQQIGSVKLQTYKEYFKV 708
            ::       .|:|.   :|.:..|....||.:|    .|::.|  .|..|.|.|..:||..|.|.
Mouse   723 LKESPAQRDEDAVLASGDEKDEGKEPETEEFVDTNAPAHQLIQ--TESPQEGIVTWKTYHTYIKA 785

  Fly   709 LGHPLVVVLILLMFVVARSSEATMDIFLSKW---------------------ATWEETEPNQHEP 752
            .|..||..|:|.:|.:...|.|....:|..|                     .|.::|:.:.::
Mouse   786 SGGYLVSFLVLCLFFLMMGSSAFSTWWLGIWLDRGSQVVCASQNNKTACNVDQTLQDTKHHMYQ- 849

  Fly   753 IPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATS 817
                        ::|...::..|:|.:::.|.|...||..|..:|:::|..::|:.|.||....:
Mouse   850 ------------LVYIASMVSVLMFGIIKGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPT 902

  Fly   818 GRILNRFSSDVLAIDVNLP---QAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRC 879
            ||::||||.|:..:||.||   :..:......|..|.::|.|..  :.|::.|.:.|..|...|.
Mouse   903 GRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVIMAAVFP--VVLVVLAGLAVIFLILLRI 965

  Fly   880 LYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERD-----FHYYQNENTS-ALY 938
            .:.|. :.||::|.|||||.:||..::.:||..|.|     |.::|     |....:||:| .||
Mouse   966 FHRGV-QELKQVENISRSPWFSHITSSIQGLGVIHA-----YDKKDDCISKFKTLNDENSSHLLY 1024

  Fly   939 LHVSINRAFAFWTDLI--CVLYILA--VTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMR 999
            .:.:: |.||...|::  .|.:::|  ||.||      ....:...||:::..::|..:.|..:|
Mouse  1025 FNCAL-RWFALRMDILMNIVTFVVALLVTLSF------SSISASSKGLSLSYIIQLSGLLQVCVR 1082

  Fly  1000 QTVELENMMTSVERVMEYVNIPSEPAYETEESV-NLPKHWPSGGQLDFRDLRLRYSNHGPYILKG 1063
            ...|.:...||.|.:.||: :...|.:.....| ..||.|||.|::.|:|.|:||.::.|.:|.|
Mouse  1083 TGTETQAKFTSAELLREYI-LTCVPEHTHPFKVGTCPKDWPSRGEITFKDYRMRYRDNTPLVLDG 1146

  Fly  1064 LTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDP 1127
            |...|:..:.:||||.|.:||||:..|||||.. .:|.|.||..:...:||.|||.::::|||||
Mouse  1147 LNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIIIDEVDICTVGLEDLRTKLTMIPQDP 1211

  Fly  1128 VLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLAR 1192
            |||.|::|:||||....|||.||..||...:::.:..|.:.:...:.:.|.|||:|:|||:|:||
Mouse  1212 VLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCMAR 1276

  Fly  1193 ALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVE 1257
            ||||.:||:::|||||::|.:||.|:|..|...|..||||||||||:||::.|.|:|::.|:|:|
Mouse  1277 ALLRNSKIILLDEATASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVIE 1341

  Fly  1258 LGHPHEL 1264
            ...|..|
Mouse  1342 FDKPEVL 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	424/1372 (31%)
		ABC_membrane	92..358	CDD:294371	68/282 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	92/219 (42%)
		ABC_membrane	762..988	CDD:294371	69/238 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	103/219 (47%)
Abcc12	NP_766500.3	MRP_assoc_pro	43..1366	CDD:188098	424/1372 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..492		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..749		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841701
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650