DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11898 and Cftr

DIOPT Version :9

Sequence 1:NP_651679.2 Gene:CG11898 / 43451 FlyBaseID:FBgn0039645 Length:1320 Species:Drosophila melanogaster
Sequence 2:XP_006236159.1 Gene:Cftr / 24255 RGDID:2332 Length:1530 Species:Rattus norvegicus


Alignment Length:1524 Identity:400/1524 - (26%)
Similarity:700/1524 - (45%) Gaps:276/1524 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQE-LKRSK 72
            |.:|:.||:|.||.||.||..||.||.:.:|:.||:|:...|..:..:|..|...|::| ..:.|
  Rat    56 QKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDREQASKKK 120

  Fly    73 PNVLRMIFKAYGWSFVPASIVYSIMAIAVHTT---QPLMLGGLVSFFSESTGKITKHSAYLYAMG 134
            |.::..:.:.:.|.||    .|.::......|   ||::||.:::.:.....:....:.|| .:|
  Rat   121 PQLIHALRRCFVWRFV----FYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIAIYL-GIG 180

  Fly   135 VVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTF 199
            :.|..::..|..||.:..|..:|.::|:|...|:|:|.|::|....:....|..|||::.:|..|
  Rat   181 LCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLISLLSNNLNKF 245

  Fly   200 NESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGD 264
            :|.....|.:|..||:.|:.:.:::.|:.:.|..|||.::..:..||...:.:.:|:...|...:
  Rat   246 DEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAKIN 310

  Fly   265 ERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYI---------YAGLQCTGMI 320
            ||:.:.:|:|..:..:|.|.||.:..|:|..:|:||:...|.|.|:         ::|.      
  Rat   311 ERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGF------ 369

  Fly   321 SKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQ 385
              ..:|||::.|.....||. :|:|...|:...|..|:...:|.|:.:|.::..:..:::|||..
  Rat   370 --FVVFLSVLPYTVINGIVL-RKIFTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDFLQT 431

  Fly   386 HENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASW---------------DQK 435
            .|         :|..|.|.   .|.|           :.:..::|.|               |.:
  Rat   432 QE---------YKVLEYNL---MFTG-----------LVMENVTAFWEEGFQELLEKVQLNNDDR 473

  Fly   436 KQEKRHRH-------------IEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEV 487
            |......|             :::::...:..:.:.|.|:.||||::||.:|||||:...|.::.
  Rat   474 KTSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEGIIKH 538

  Fly   488 NGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLS 552
            :|.:|::.|..|::.|::::||:|...|||.||..|::.|.|..|:.:....|:|.:||||.:||
  Rat   539 SGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLS 603

  Fly   553 GGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVD 617
            |||:||:|||||||:.||:||||.|...:|....:.:.:.|:.:.::.|.|||||.:::.|:..|
  Rat   604 GGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTRILVTSKMEQLKKAD 668

  Fly   618 HLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRH 682
            .:::|..|.....|.:..|:.|   |...::       :.|..|:..:..|.|:|....|.:.|.
  Rat   669 KILILHEGSSYFYGTFSELQSL---RPDFSS-------KLMGYDTFDQFTEERRSSILTETLRRF 723

  Fly   683 EIE----------QQFKEQQQIGSVK-------LQTYKEYFKVLGHPLVV--------------- 715
            .::          |.|::..:.|..:       ..:.|:...|...||.:               
  Rat   724 SVDDASTTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIEGESDDLQERRLSLV 788

  Fly   716 -----------------------------VLILLMFV---VARSSEATM---------------- 732
                                         ||.|:.|.   |:.|.:.|.                
  Rat   789 PDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQRTRASIRKISLAPRISLKE 853

  Fly   733 -DIF---LSKWATWEETEPNQHEPIPEYH-------------RTRLRMMI----LYTFLILCTLI 776
             ||:   ||:.:|...||....|.:.|..             .|.||...    |:..||.|.|:
  Rat   854 EDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTTWNTYLRYFTLHRGLFAVLIWCVLV 918

  Fly   777 FYVLRTFGFFMM--------------------------------------------TLRISL--- 794
            |.|......|::                                            .|.:||   
  Rat   919 FLVEVAASLFVLWLLKNNPVNGGNNGTKIANTSYVVVITSSSFYYIFYIYVGVADTLLALSLFRG 983

  Fly   795 ------------RIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAV 847
                        .:|.::...::.|.|..|....:|.||||||.|:..:|..||..:.|.|:...
  Rat   984 LPLVHTLITASKILHRKMLHSILHAPMSTFNKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLF 1048

  Fly   848 NALAVLAVVSTANIWLL---IPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKG 909
            ..:..:.|||....::.   :|...|..||   |..::..|:.||::|:..||||::|...:.||
  Rat  1049 IVVGAIIVVSALQPYIFLATVPGLAVFILL---RAYFLHTSQQLKQLESEGRSPIFTHLVTSLKG 1110

  Fly   910 LATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRG 974
            |.|:||.....|.|..||...|.:|:..:::::..|.|....|:|.||:.:.|||..:|   ..|
  Rat  1111 LWTLRAFRRQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISIL---TTG 1172

  Fly   975 YYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPA--------YETEES 1031
            ...|..|:.:|.:|.::...|..:..:::.:::|.||.||.::::|.:|.:        ..:|:|
  Rat  1173 EGEGTTGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDS 1237

  Fly  1032 VNL----PKH------WPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSS 1086
            .|.    .:|      |||||::..:||.::|.:.|..||:.::|:|...:::|::|.|.:|||:
  Rat  1238 PNALVIKNEHVKKCDTWPSGGEMVVKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKST 1302

  Fly  1087 IVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWL 1151
            ::.|..|:.:|.|.|.|||...:.:.|.:.|:...:|.|...:|||:.|.||||..:..|||:|.
  Rat  1303 LLSAFLRMLNIKGEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWK 1367

  Fly  1152 ALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDN 1216
            ..:.|.||..:......:|..|.|.|...|.|.:||:||||::|.:.||:::||.:||:||.|..
  Rat  1368 VADQVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQ 1432

  Fly  1217 LIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGV 1281
            :|:..:...||.|||:...||:..::|..|.:|::.|.|.:......||..: ....|.:..:..
  Rat  1433 VIRRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEK-SVFQRALSSSEK 1496

  Fly  1282 GTAQHLRHLAEQSYRKRVLGRKSEDQGSV 1310
            ....|.||.::|..|.::...|.|.:..|
  Rat  1497 MKLFHGRHSSKQKPRTQITAVKEETEEEV 1525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11898NP_651679.2 CFTR_protein 9..1268 CDD:273530 391/1480 (26%)
ABC_membrane 92..358 CDD:294371 70/277 (25%)
ABCC_MRP_domain1 423..626 CDD:213217 74/230 (32%)
ABC_membrane 762..988 CDD:294371 72/291 (25%)
ABCC_MRP_domain2 1042..1261 CDD:213211 77/218 (35%)
CftrXP_006236159.1 CFTR_protein 55..1518 CDD:273530 397/1515 (26%)
ABC_membrane 139..357 CDD:294371 58/218 (27%)
ABCC_CFTR1 444..724 CDD:213258 87/300 (29%)
CFTR_R 693..898 CDD:291094 30/211 (14%)
ABC_membrane 915..1196 CDD:279056 70/286 (24%)
P-loop_NTPase 1258..1518 CDD:304359 85/260 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345085
Domainoid 1 1.000 58 1.000 Domainoid score I10508
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.950

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