DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc4

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001028508.2	Gene:	Abcc4 / 239273	MGIID:	2443111	Length:	1325	Species:	Mus musculus

Alignment Length:	1331	Identity:	486/1331 - (36%)
Similarity:	764/1331 - (57%)	Gaps:	69/1331 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65
            |..||.:.:|||:..||..|:.||.|...:...|.:|.|:..|::...|...|..:...|..:|:
Mouse     1 MLPVHTEVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWD 65

  Fly    66 QELKRS-----KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFS--ESTGKI 123
            :||.|:     ||::.:.|.|.|..|::...| ::::.......|||.||.::.:|.  :....:
Mouse    66 KELLRAKKDSRKPSLTKAIIKCYWKSYLILGI-FTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSV 129

  Fly   124 TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYA 188
            ..|:||.||..:.:|:||..:..|.:..::...|.|:|:|...::|||.||:|.:|.....:|..
Mouse   130 ALHTAYGYAAVLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQI 194

  Fly   189 ISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIA 253
            ::|::.|:..|::.....|.||.|||:.:....:::..||...:.||..:|..:|||:...:..:
Mouse   195 VNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFS 259

  Fly   254 RYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTG 318
            ..:..:|...|.|::.|||:|..|::|||||||||||.||..:||:|:..|.||:|: .|:....
Mouse   260 SLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYL-RGMNMAS 323

  Fly   319 --MISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKD 381
              :.:|:.||::..:||..|:.:|:..||:..:.|..:..::...:|.||....|..|...|:|:
Mouse   324 FFIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKN 388

  Fly   382 FLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIED 446
            ||...|.|.                    .:.|.|......:.|...:|.||:......   ::.
Mouse   389 FLLLDELPQ--------------------RKAHVPSDGKAIVHVQDFTAFWDKALDSPT---LQG 430

  Fly   447 VSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILF 511
            :||.|:..:.:.:||.||||||:||..:||||...||.|.|:|.::|..|:||:..|::|.||||
Mouse   431 LSFIARPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILF 495

  Fly   512 TEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDD 576
            .:.|:::||.:|::.|.|.:|::.|..||.|.:|:.||:|||||||||:||||||:.||||||||
Mouse   496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDD 560

  Fly   577 PLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHY-DALKKLI 640
            ||||||:.|.|.|...|:.:.|.:||.|||||::|.|:...|:::|:.|.:..:|.| :.||..:
Mouse   561 PLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGV 625

  Fly   641 RF-----------RMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQ--EEHMDRHEIEQ-QFKEQ 691
            .|           ..|.|......:.|.....|::.:...|.||..  .|..|....:. |.:|.
Mouse   626 DFGSLLKKENEEAEPSTAPGTPTLRKRTFSEASIWSQQSSRPSLKDGAPEGQDAENTQAVQPEES 690

  Fly   692 QQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWE---ETEPNQHEPI 753
            :..|.:..:.||.||........::.::|:.:|.:......|.:||.||..:   ....|.:..|
Mouse   691 RSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTRNANGNI 755

  Fly   754 PE------YHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFF 812
            .|      |       :.:|..|...|::|.:.|:...|.:.:..|..:|:::|:.:::|.:.||
Mouse   756 TETLDLSWY-------LGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVLFF 813

  Fly   813 TLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGC 877
            .....||||||||.|:..:|..||...:|.|:..:..::|:||.:....|:|||...:..:....
Mouse   814 DRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVL 878

  Fly   878 RCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVS 942
            |..::..||.:||:|:.:|||::||.:::.:||.||||....:..:..|..:|:.::.|.:|.::
Mouse   879 RRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLT 943

  Fly   943 INRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENM 1007
            .:|.||...|.||.::::.|.|..|:..|...  :|.||||::.::.|:.|.|..:||:.|:|||
Mouse   944 TSRWFAVRLDAICAIFVIVVAFGSLVLAKTLN--AGQVGLALSYALTLMGMFQWSVRQSAEVENM 1006

  Fly  1008 MTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEE 1072
            |.|||||:||.::..|..:|.::  ..|..||..|.:.|.::...||..||.:||.||..|:..|
Mouse  1007 MISVERVIEYTDLEKEAPWECKK--RPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSRE 1069

  Fly  1073 KIGIVGHTAAGKSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFN 1137
            |:||||.|.|||||::.|||||:...|.|.||...|:::||||||:::|||||:||||:|::|.|
Mouse  1070 KVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKN 1134

  Fly  1138 LDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILI 1202
            ||||.|.||||||.|||.|:|||.:.:|...::..|.:.|:|||:|||||||||||:|:.|:|||
Mouse  1135 LDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILI 1199

  Fly  1203 MDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHN 1267
            :|||||||||.||.|||:.|..|||.||||||||||:|::|:|::||:|.||:.|...|:.||.|
Mouse  1200 IDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQN 1264

  Fly  1268 RHGYLHRFVEKTGVGTAQHLRHLAEQSYRKR 1298
            .....::.|::.|.|.|..|...|:|.|.:|
Mouse  1265 PESLFYKMVQQLGKGEAAALTETAKQVYFRR 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	473/1291 (37%)
		ABC_membrane	92..358	CDD:294371	84/269 (31%)
		ABCC_MRP_domain1	423..626	CDD:213217	95/202 (47%)
		ABC_membrane	762..988	CDD:294371	69/225 (31%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	128/218 (59%)
Abcc4	NP_001028508.2	PLN03130	12..1284	CDD:215595	476/1307 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..690		7/32 (22%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:O15439	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841679
Domainoid	1	1.000	97	1.000	Domainoid score	I7210
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.750