DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCD2

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_005155.1	Gene:	ABCD2 / 225	HGNCID:	66	Length:	740	Species:	Homo sapiens

Alignment Length:	800	Identity:	157/800 - (19%)
Similarity:	278/800 - (34%)	Gaps:	231/800 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRSKP 73
            :|:|...|:||.:  .:..|:||.                |.|.:|:.
Human    75 KPSPGVNADFFKQ--LLELRKILF----------------PKLVTTET----------------- 104

  Fly    74 NVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKH------SAYLYA 132
                      ||      :....:|:...|...:.:.||       .|||.|.      ..::..
Human   105 ----------GW------LCLHSVALISRTFLSIYVAGL-------DGKIVKSIVEKKPRTFIIK 146

  Fly   133 MGVVLCSLISGLFFHPFMKYL---FRVGSRVRLA-------CAGLVYRKFLRVSVAADNSGVSGY 187
            :...|...|...|.:..::||   ..:..|.||.       .....|.|.:.:.....|...|
Human   147 LIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMDGRLANPDQS-- 209

  Fly   188 AISLMATDLPTFNESF-YCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLG-TIVAFIPLQAWAAR 250
                :..|:..|::|. :.:..|.:..|:.::..|.:.|.........:| |::|.:.:.|.|..
Human   210 ----LTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLAGLVVYATAKV 270

  Fly   251 AIARYKRSSADVGDERVK------LMNEIIAAMQLIKMYAWEKSFAKLIGKVRK---EEMDSIRG 306
            ..|...:....|.:|..:      :.:.|||.::.|..|...|...|.:.|..|   ::|:.|..
Human   271 LKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILS 335

  Fly   307 STYIYAGLQ---------CTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLND--SLLH 360
            ....|..::         .:|:|   .:.:.::|.....|....||..:|:...:....  :||.
Human   336 KRLWYIMIEQFLMKYVWSSSGLI---MVAIPIITATGFADGEDGQKQVMVSERTEAFTTARNLLA 397

  Fly   361 SWPLAINMWVETFVVANRVKDF------LFQHENPADGGVHN----FKEAEDNPEHGNFFGRTHK 415
            |...||...:.::.....:..:      :|...:....|::.    .:|:|.:.::|   .:...
Human   398 SGADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNG---AKVEL 459

  Fly   416 PKAEVKSITVHKLSASWDQKKQEKRHRHI-EDV--------------SFQAQDQQFVGIVGTVGA 465
            |.::..:|         ..|..:..|..| |:|              :|:.::...:.|.|..|.
Human   460 PLSDTLAI---------KGKVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGC 515

  Fly   466 GKSTLLQVILGELDIISGSVEVNGVL--------SYAPQEPWLLRGSLRDNILFTEP-------- 514
            |||:|.:::.|...:      ..|||        .|.||.|::..|||||.:::.:.
Human   516 GKSSLFRILSGLWPV------YEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKG 574

  Fly   515 YDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGAS--------LSGGQKARVSLARAVYRKADI 571
            |.:|....:|...||...|::          |||..        ||||:|.|:.:||..|.|...
Human   575 YTDQDLERILHNVHLYHIVQR----------EGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKY 629

  Fly   572 YLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQG--HYD 634
            .|||:..|||...|...:........:|   .:.:|||..|.::..||:..:|     :|  .::
Human   630 ALLDECTSAVSIDVEGKIFQAAKGAGIS---LLSITHRPSLWKYHTHLLQFDG-----EGGWRFE 686

  Fly   635 ALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKL 699
            .|...||..:|.                                      |:|..|.|..|..|:
Human   687 QLDTAIRLTLSE--------------------------------------EKQKLESQLAGIPKM 713

  Fly   700 -QTYKEYFKVLGHPLVVVLI 718
             |...|..|:||...|:..|
Human   714 QQRLNELCKILGEDSVLKTI 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	156/799 (20%)
		ABC_membrane	92..358	CDD:294371	54/303 (18%)
		ABCC_MRP_domain1	423..626	CDD:213217	61/241 (25%)
		ABC_membrane	762..988	CDD:294371
		ABCC_MRP_domain2	1042..1261	CDD:213211
ABCD2	NP_005155.1	Interaction with PEX19	1..218		34/206 (17%)
		3a01203	74..685	CDD:273360	140/712 (20%)
		ABC_membrane_2	80..365	CDD:284003	60/351 (17%)
		ABCD_peroxisomal_ALDP	478..683	CDD:213190	59/228 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1117
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860