DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc9

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_035641.1	Gene:	Abcc9 / 20928	MGIID:	1352630	Length:	1546	Species:	Mus musculus

Alignment Length:	1356	Identity:	390/1356 - (28%)
Similarity:	662/1356 - (48%)	Gaps:	130/1356 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKRS------KPNV 75
            |..||..:.|...:::...::.:|...:.:...::.:......|...:|::.|::      .|::
Mouse   221 NLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSI 285

  Fly    76 LRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSEST------------GKITKHSA 128
            ...:::|:|...:.:| .:..:|..:....||.:.|:|...:|.|            .|....:|
Mouse   286 WLAMYRAFGRPILLSS-TFRYLADLLGFAGPLCISGIVQRVNEKTNTTREMFPETLSSKEFLENA 349

  Fly   129 YLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSG--VSGYAISL 191
            ::.|:.:.|..::...|...........|..:|.|...::|.|.||:|.:..:.|  ..|...:|
Mouse   350 HVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNL 414

  Fly   192 MATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYK 256
            :|.:........:....||..|::.::.|.::|.|:|..|:||...||...|:|.:.|..:|..:
Mouse   415 VAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQ 479

  Fly   257 RSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMIS 321
            :|:.|...||:|..|||:..::|:|:||||..|.|.:.:.|.:|:.|::  |:        .:.:
Mouse   480 KSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLK--TF--------ALYT 534

  Fly   322 KLSLFLS--------LVTYV----FTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFV 374
            .||:|::        |.|:|    .:|:.:...:.|...|.: |:..:.|......:...|:..:
Mouse   535 SLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLF-HILVTPLFLLSTVVRFAVKAII 598

  Fly   375 VANRVKDFLFQHENPADG-----GVHNFKE------AEDNPEHGNFFGRTH----------KPKA 418
            ...::.:||...|...|.     |...|:.      .:..|.:....||.|          :| |
Mouse   599 SVQKLNEFLLSDEIGEDSWRAGEGTLPFESCKKHTGVQSKPINRKQPGRYHLDSYEQARRLRP-A 662

  Fly   419 EVKSITVHKLSA--SWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDII 481
            |.:.|.:...:.  ||......     :.::..:....|...|||.||.|||:||..||||:..:
Mouse   663 ETEDIAIKVTNGYFSWGSGLAT-----LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTL 722

  Fly   482 SGSVEVNGV-----------------LSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHL 529
            .|.|..|.|                 ::||.|:||||..::.:||.|..|::.|||..|...|.|
Mouse   723 EGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSPFNRQRYKAVTDACSL 787

  Fly   530 DRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCL 594
            ..|::.||.||.|.:||.|.:|||||:.|:.:|||:|:..:|..||||.||:|.|:|..|:...:
Mouse   788 QPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 852

  Fly   595 NEFL--SKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGH-----------YDALKKLI-RFRMS 645
            .:||  .|:..:||||::|.|.|.|.::.::.|.:..:|.           |:..|.|: |....
Mouse   853 LKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQE 917

  Fly   646 VANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKLQT---YKEYFK 707
            :..|:| |....:...::......|::.:|.|..|..|.|::.:|......::|:|   :|..:.
Mouse   918 LEKDME-ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPWKTCWW 981

  Fly   708 VLGHPLVVVLILLMF--VVARSSEATMDIFLSKWAT-WEETEPNQHEPIPEYHRTRLRMMILYTF 769
            .|......:|.|::|  ::..|....:|.:|:.|.: :....|.:.:          :...:..|
Mouse   982 YLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINHPGKAD----------QTFYVAGF 1036

  Fly   770 LILCTL-IFYVLRT-FGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAID 832
            .|||.. ||..|.| .....|.|..:..:|..|...:|...:.||.....|.||||||:|...||
Mouse  1037 SILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIID 1101

  Fly   833 VNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRS 897
            .::|..:.......:..|:.:.::|.|....|:....:....|..:..:..||:.|:.::..::.
Mouse  1102 QHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQL 1166

  Fly   898 PIYSHTNATFKGLATIRAL-NGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILA 961
            |:..|.:.|.:||.||||. :.|::.:|........|.:.|:|..: ||.....||.:....:|.
Mouse  1167 PLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAA-NRWLEVRTDYLGACIVLT 1230

  Fly   962 VTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAY 1026
            .:.:.:....:    ||.|||.:..::.:.......:|...:||..|.:|::|..::.:.||...
Mouse  1231 ASIASISGSSN----SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYE 1291

  Fly  1027 ETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHAL 1091
            .|.:...:|:|||..|::...||.:||.|:...:||.:...|:..:|:||.|.|.:||||:..|.
Mouse  1292 GTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAF 1356

  Fly  1092 FRLAHI-NGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEA 1155
            ||:..| :|.|.|||.:.|:|.||.||.|:|||.|||:|||||:||||||..:.||:.||.|||.
Mouse  1357 FRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEI 1421

  Fly  1156 VKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQE 1220
            .:||..|.:|..|::..:.:.|.|||:|||||.|||||.:|::.|||||||||::|..|:|::|:
Mouse  1422 AQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1486

  Fly  1221 AIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFV 1276
            .:.|.||..||:|||||:||::..|.|:|:..|.::|...|..||....|....||
Mouse  1487 VVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFV 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	387/1346 (29%)
		ABC_membrane	92..358	CDD:294371	70/291 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	80/223 (36%)
		ABC_membrane	762..988	CDD:294371	58/228 (25%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	108/219 (49%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	390/1356 (29%)
Abcc9	NP_035641.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.730