DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and mrp-8

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_499598.2	Gene:	mrp-8 / 190710	WormBaseID:	WBGene00003414	Length:	1461	Species:	Caenorhabditis elegans

Alignment Length:	1361	Identity:	410/1361 - (30%)
Similarity:	662/1361 - (48%)	Gaps:	184/1361 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQR-QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELK 69
            ||: :..|..|::|.||.||.|...::..|.::.|....|:    :|.....|.:|...|..|..
Worm   170 EQKIEQTPEEKSSFLSKIFFCWLNPLIRAGAKQPLTNESLH----NLNENATSEWLYTRWRAEFD 230

  Fly    70 RSKPNVLRMIFKAYG-----WSFV---PASIV----YSIMAIAVHTTQPLMLGGLVSFFSESTGK 122
            :.|..      :..|     |.|:   .|:|:    ..:.|..||...|::|..|:.:
Worm   231 KEKAG------RKSGETSIVWPFIRIQRATIITLTLARLTADIVHYLNPILLKQLIDY------- 282

  Fly   123 ITKHSAYLYAMGVVL------CSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADN 181
            ::.|...| :.|:.:      ||....|..:..:..:.|.....:...:..:..|.||:|.:|.:
Worm   283 VSLHDQPL-SFGIAIACIMFSCSTTRSLLQNYQIAGMCRQAVYYQTVLSNAILHKILRLSPSARS 346

  Fly   182 SGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQA 246
            :..:|..::..|.|:.....|......:|..|.:..:.:.::...:||.|:.|:..::.||||..
Worm   347 NRTAGEILNHAAVDIEIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVCIMILFIPLNL 411

  Fly   247 WAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRG----S 307
            ..:|.|...::....:.|||.||.||::..::::|:||||:||...|.::|.:|:..:|.    |
Worm   412 CTSRFIKLSQQKQMKIKDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKMLRNVCILS 476

  Fly   308 TYIYAGLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVET 372
            ..:......:..:..:..|...|.:....:.:|....|:..:.::.|...:.....| ||..|:.
Worm   477 RIVDVANAASPFLVAIGSFTCYVLWSPDENGLTPSVAFVALTIFNQLRQPMRMVANL-INTLVQA 540

  Fly   373 FVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEV---KSITVHKLSASWDQ 434
            .|...|::.||            |.:|.|              .|.||   .:|.....|.:|
Worm   541 RVSNKRLRQFL------------NDEEME--------------RKTEVALGNAIVFKNASLNW-- 577

  Fly   435 KKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPW 499
             |..:....::|:|...:..|.:.|||:||.|||:||..:|.|:.::.|.|:|.|.::|.||..|
Worm   578 -KGPQNPPVLKDLSATIKPGQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRVKVGGSIAYVPQHSW 641

  Fly   500 LLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARA 564
            :...::::||||........|.:|:..|.|..|......|::|.|||.|.:||||||||:|||||
Worm   642 IFNKTIKENILFGNELSNYFYDQVVGSCQLKTDFRHFQQGENTMVGENGITLSGGQKARISLARA 706

  Fly   565 VYRKADIYLLDDPLSAVDSHVSKMLLDRCL--NEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRI 627
            ||:..|||||||||||||:||.:.|.|:.:  :..|..|.|:||||.:|..::||.:.::|.|:|
Worm   707 VYQDKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLLRSKTRVLVTHNLQYTKYVDTIYVIEDGQI 771

  Fly   628 SVQGHYDALKKLI----RFRMSVAN-DVEVAKLRAMRTDSVYEEPEP----------RKSLSQEE 677
            ...|.::.:..:.    |......| |.:||...|..:::....|.|          .|| ||.:
Worm   772 VQHGSFEDIAYVDGPFGRLWSECENSDEDVADEEAESSEASVTPPVPVLENGDNGAIEKS-SQID 835

  Fly   678 HMDRHEIEQQFKEQQ------------QIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEA 730
            ..:.|..|:..|.::            |:|.||...|:.|.|.:|  :......|:|.:|..:..
Worm   836 RTNSHFSEKSRKSEEKPQKVEKNVENVQLGRVKKSVYQLYIKTMG--IFNSSAFLIFFIAHFTVM 898

  Fly   731 TM-DIFLSKWATWEETEPNQHEPI-------------------PEYHRTRLRMMILYT-----FL 770
            .| .::||.|:       |::..|                   |....|||   |:|.     .:
Worm   899 IMRSLWLSDWS-------NENAAIKKATLSSVDYLNSTSSVDGPVSVETRL---IVYAGFGGLEM 953

  Fly   771 ILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNL 835
            :|..|.|.|| |.|    :||.|..:|..|...::.|.:.||....:|||:||.|.|:..||
Worm   954 LLLALAFTVL-TIG----SLRASYGLHSPLIHALLVAPISFFDTTPTGRIINRLSRDLDVID--- 1010

  Fly   836 PQAMMDSIEFA----VNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISR 896
              .:.|:|...    :||..:|.::|.:....|:.|..::.:.|.....||..||.|||:|:.:|
Worm  1011 --KLQDNIRMCTQTLLNACMILVLISISTPIFLVCAAPLILIYYFVMIYYIPTSRQLKRLESANR 1073

  Fly   897 SPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSAL-----------YLHVSINRAFAFW 950
            |||.|....:..|.::|||.:.|:           ..|:||           ||....||..|..
Worm  1074 SPILSTIAESIHGASSIRAFDKTE-----------RTTTALSTNVDKFAQCRYLSHMSNRWLATR 1127

  Fly   951 TDLI---CVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVE 1012
            .:|:   |||:   .:.|..|..|:.|...|..||:::.::.:..:....:|...|:|:.:.|||
Worm  1128 LELLGNTCVLF---ASLSATLSTKYFGLTPGMAGLSVSYALTITEVLNICVRSVSEIESNIVSVE 1189

  Fly  1013 RVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIV 1077
            ||.||..:..|..:..|:|:...:.||..|:::.....:||..:.|.:||.:...|.|.|:||::
Worm  1190 RVNEYQKLEPEAPWRIEKSLENEEKWPVKGKIELDGFSMRYRKNLPLVLKNIDLKIEGGERIGVI 1254

  Fly  1078 GHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPF 1141
            |.|.:||||:..||:|:.. .:|.|.||..|...:|||.||.::.||||:||:|||:||||||||
Worm  1255 GRTGSGKSSLTMALYRMIEGESGTIKIDDVEIDTIGLHQLRSKLIIIPQEPVVFSGTLRFNLDPF 1319

  Fly  1142 EEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEA 1206
            .:.:|:::|..||..:||:|.......::..:.:.|.|.|:|:|||:||.|||||..:|:|:|||
Worm  1320 NQYSDDQIWNCLEICQLKQFAQEDDKTLDRYIAEGGKNMSVGERQLLCLCRALLRGARIVILDEA 1384

  Fly  1207 TANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHN 1267
            ||:||..||.::|.||...|...|.::|||||.|::|:||::|:|.|||.|...|..||.|
Worm  1385 TASVDTVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVVLDAGRVAEFDTPSNLLLN 1445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	408/1357 (30%)
		ABC_membrane	92..358	CDD:294371	59/279 (21%)
		ABCC_MRP_domain1	423..626	CDD:213217	85/204 (42%)
		ABC_membrane	762..988	CDD:294371	72/248 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	99/219 (45%)
mrp-8	NP_499598.2	CFTR_protein	173..1459	CDD:273530	408/1358 (30%)
		ABC_membrane	259..527	CDD:294371	58/275 (21%)
		ABCC_MRP_domain1	568..770	CDD:213217	85/204 (42%)
		ABC_membrane	887..1168	CDD:294371	85/314 (27%)
		ABCC_MRP_domain2	1219..1439	CDD:213211	99/219 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710