Protein Alignment CG11898 and mrp-3

DIOPT Version :10

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_001359552.1
• Gene: mrp-3 / 181677
• WormBaseID: WBGene00003409
• Length: 1505
• Species: Caenorhabditis elegans
• Alignment Length: 1381
• Identity: 409/1381 - (29%)
• Similarity: 681/1381 - (49%)
• Gaps: 198/1381 - (14%)

  Fly    12 PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQE-LKRS---- 71
            |...|||.|:...:|..:|:..|.:|.|...|::|    ::|.....:|...|:.| ||::
 Worm   194 PEENANFISRQLLLWFTQIISLGYERTLVADDVFE----MDSQMDQEYLKARWKTEWLKQTEKAR 254

  Fly    72 ------------------------------------------KPNVLRMIFKAYGWSFVPASIVY 94
                                                      :|:|:..:::...|..:..|.:
 Worm   255 EKQVKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWEILGGSFI- 318

  Fly    95 SIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSR 159
            ..::..:....|..|..|:.|.......:.  :....|:|:.|...|..||.:.:...:.|||::
 Worm   319 KFLSDLLQFANPTFLNYLILFIETPNAPLI--NGIGLAVGLFLAGQIKSLFMNTYFIAMTRVGAK 381

  Fly   160 VR--LACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYI 222
            ::  |:||  ||.|.|.:|..|......|..:::::.|:..|........:.|..|.:.::.:.:
 Worm   382 IQTMLSCA--VYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVL 444

  Fly   223 IYQLIGWPAVVGLGTIVAFIPL--------QAWAARAIARYKRSSADVGDERVKLMNEIIAAMQL 279
            :.|.||.....|:..:::.:|:        :.|..| :.:||       |||::|:||::..:::
 Worm   445 LSQTIGVAVWAGIVVMISIVPINICVSMITKRWQLR-LMKYK-------DERIRLINEVLNGIKV 501

  Fly   280 IKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLSLVTYVFT----GDIVT 340
            :|:.|||.:..:.|.:||.:|:..|:.|..:.....|..:.:.:.:.||..| ||.    .:::|
 Worm   502 VKLSAWETAMEETIERVRDKELKMIKQSALLKTFADCLNVGAPVFVALSSFT-VFVLIDPKNVLT 565

  Fly   341 SQKVFIVASYYDHLNDSLLHSWPLAINMWVET--FVVAN-RVKDFLFQHENPADGGVHNFKEAED 402
            ....|:..|.::.|...|:    :|..:..:|  .||:| ||:.||.:.|...        .|.|
 Worm   566 PNIAFVSLSLFNLLRGPLM----MAAELVAQTVQLVVSNKRVRTFLCEKEVDT--------AAID 618

  Fly   403 NPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGK 467
            ....|..:..|         :.:|..|.:||..:.    |.:.|:.|.|..::.|.:||:||:||
 Worm   619 KEIRGELYTNT---------VEIHSGSFAWDSAEA----RILSDIEFLAGSKELVTVVGSVGSGK 670

  Fly   468 STLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRD 532
            |:||...|||::.:.|.|.|.|.::|..|:||:|..||:.|:|.....::..|.:|:..|.|..|
 Worm   671 SSLLLAALGEMEKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLNDVLYKKVIESCALKED 735

  Fly   533 VEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCL--N 595
            ::|||.||.|.:||.|.:||||||||::||||||:..|:|.|||||||||:||.|.:.|..:  |
 Worm   736 LKQLPDGDDTEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDNVIGPN 800

  Fly   596 EFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRM---------------- 644
            ..||...|||||:....|:....:::::.|||...|.|:.|...:..|.
 Worm   801 GMLSHTTRILVTNCTSFLQESGKIIVMKDGRIKHCGTYNELLTDVEAREYLQEVDNEYAQAQESS 865

  Fly   645 ---------------SVANDVEVAKL-------RAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQ 687
                           |:|:...:::|       |.....|:.|:.:|...::
 Worm   866 GEESGGEENSDILPGSIASGSRMSRLSRLSKISRKKSKSSIVEKKKPDALIT------------- 917

  Fly   688 FKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWAT-WEETEPNQHE 751
             ||:..||.|....|..|||.:|    :|..:|.:.:|.....:..:..|.|.| |.:...:.:.
 Worm   918 -KEEAAIGRVNPGVYLLYFKAMG----IVTYVLPYAIAVVLNVSFALGRSLWLTAWSDANIDINH 977

  Fly   752 PIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRI------SLRIHDQLFQGVIRAFMH 810
            |.......||.   :|....:..:||.      ||.:.|.:      |..:|..|...|:|..:.
 Worm   978 PDTMSVGARLG---VYAGFGITEVIFL------FFSLVLLLIGGVAASKNLHKPLLHNVLRNPLS 1033

  Fly   811 FFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTAN---IWLLIPATVV-- 870
            :|.:...|||:||.:.|:..:|:.|..:....:...:|.:..:.:||...   |.::||..::
 Worm  1034 YFDITPIGRIINRLAKDMEVVDLRLSSSFRFLVMALINMVQTVLIVSYTTPLFIAIIIPVFIIYF 1098

  Fly   871 VALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTS 935
            ..|.|.     |.::|.|:||.:::||||:|:.:.|.:|::|:||...:....|....:.|.:..
 Worm  1099 FVLKYS-----IKSTRQLQRIASLTRSPIFSNFSETLQGISTVRAFQWSDEFVRRNDEHLNTHVK 1158

  Fly   936 ALYLHVSINRAFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGM 998
            ..|.....||..:...:|:  .|::..|:   ..:..|..|..:|.:||:::.|:.:..|....:
 Worm  1159 CSYYSQMANRWLSIRLELLGNIVIFSAAI---LAIIGKESGITAGMLGLSVSYSLNITFMLNMFV 1220

  Fly   999 RQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKG 1063
            ||..|:|..:.||||:.||....||..:..:.: |||.:||:||.::..|...||.:....:||.
 Worm  1221 RQINEVETNVVSVERIDEYSKTKSEAEWRLDNN-NLPSNWPTGGAVNIEDYSCRYRDELDLVLKQ 1284

  Fly  1064 LTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDP 1127
            ::..|...:|:|:.|.|.|||||:..||||:.. .:|:||||...||.:||||||.:::||||:.
 Worm  1285 ISLNILPGQKVGVCGRTGAGKSSLALALFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQEN 1349

  Fly  1128 VLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLAR 1192
            |||:.:||||:||..:.||::||||||...||..|..|...:...:.:.|.|||:|||||:||.|
 Worm  1350 VLFANTLRFNIDPKGQFTDQQLWLALENSNLKAHVELLPHKLESPVAEGGENFSVGQRQLLCLTR 1414

  Fly  1193 ALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVE 1257
            ||||::|:|::|||||.:|..||.::|..|..|||..|::||||||||::|.||::|:|.||:||
 Worm  1415 ALLRKSKVLVLDEATAGIDNRTDTMVQATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVE 1479

  Fly  1258 LGHPHELLHNRHGYLH 1273
            .|.|.|||.||:...:
 Worm  1480 DGIPGELLKNRNSQFY 1495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	407/1374 (30%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	409/1381 (30%)