DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11898 and pgp-14

DIOPT Version :9

Sequence 1:NP_651679.2 Gene:CG11898 / 43451 FlyBaseID:FBgn0039645 Length:1320 Species:Drosophila melanogaster
Sequence 2:NP_510128.1 Gene:pgp-14 / 181416 WormBaseID:WBGene00004008 Length:1327 Species:Caenorhabditis elegans


Alignment Length:1357 Identity:298/1357 - (21%)
Similarity:538/1357 - (39%) Gaps:303/1357 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 QPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVY 169
            ||:.:.||..:     ||  |....|..:|.: |::|||:    ....|..|..||..|.  |||
 Worm    86 QPVSIPGLFRY-----GK--KFDYLLLFIGTI-CAIISGV----SQPILALVSGRVTNAL--LVY 136

  Fly   170 ---RKFLRVSVAADNSGV-SGYAISLMATDLPTFNESFYCFHELWRGPLEGV--VFVY-IIYQLI 227
               .|..| :.|.:|..: .|..|.:..|:.    ..:.||.......:..:  .||| ::.|..
 Worm   137 PPTSKQFR-NKANENVYIFLGIGIFISITNF----IQYMCFQHCCTRVMAQMRHRFVYSVLRQNA 196

  Fly   228 GWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMN---EIIAAMQLIKMYAW---- 285
            ||......|||         ..:.....:|....:||:...|:.   .:|||:.:..:|.|    
 Worm   197 GWFDKNHSGTI---------TTKLNDSMERIREGIGDKLGVLLRGFAMLIAAIVVAYIYEWRLAS 252

  Fly   286 ---------------------EKSFAKLI-----GKVRKEEMDSIR------------------- 305
                                 ..:..:||     |.:.:|.:..:|                   
 Worm   253 MMLGVAPTCCICMSLLARQMTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAEL 317

  Fly   306 --GSTY---------IYAGLQCTGMISKLSLFLSLVTYVF-TGDIVTSQKVFIVASYYDHLNDSL 358
              |..:         .:.||....:.|.|...:....|:. .|.|.|...||||      :...|
 Worm   318 EKGRKFAVWKGFWSGFFGGLFFFWLFSFLGCGMLYGAYLLKVGIITTPGDVFIV------VMSML 376

  Fly   359 LHSWPLAI---NMWV---------ETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFG 411
            |.::.|.:   :|.|         ..:...:||..            :..:.:|....:  |..|
 Worm   377 LGAYFLGLISPHMMVLLNARVSAASIYQTIDRVPK------------IDPYSKAGKRLQ--NVVG 427

  Fly   412 RTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILG 476
            |       ||...||   ..:..:|..|   .:..::...:....|.:||..|.||||.:.::..
 Worm   428 R-------VKFENVH---FRYPSRKDAK---ILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTR 479

  Fly   477 ELDIISGSVEVNG-------------VLSYAPQEPWLLRGSLRDNILFTEP-YDEQRYLEVLRVC 527
            ..:..:|:|.::|             .:....|||.|...::.:|:|...| ...:..:||.::.
 Worm   480 LYEPEAGNVTIDGTDVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMA 544

  Fly   528 HLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDR 592
            :....:|::|.|..|.:|:||..||||||.||::||.:.|...:.|||:..||:|:. |:.::..
 Worm   545 NAHDFIEKMPKGYDTLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQ-SESIVQS 608

  Fly   593 CLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRA 657
            .||.....:..|::.||:..:|..|.:|..|.|.|...|:::.|.:|      .....::.|.:.
 Worm   609 ALNNASKGRTTIMIAHRLSTIREADKIVFFEKGVIVEAGNHEELVRL------GGRYFDLVKAQQ 667

  Fly   658 MRTD----SVYEEPE----------PRKSLS-----QEEHMDRHEIEQQFKEQQQIGSVKLQT-- 701
            .:.|    ..:||.|          .|.|::     .|.....:.:...|...::......:.  
 Worm   668 FKADPEATEEFEEEEIDLDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSA 732

  Fly   702 ------------------YKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWA----TWEE 744
                              |.:.||......:.:.:..:|.:.|..|......:..|.    |:  
 Worm   733 FAANEAAIMAEDGQITAGYLDIFKNAKGNYLYMFLGTVFALIRGLELPALALIFGWVFEGFTF-- 795

  Fly   745 TEPNQHEPIPEYHRTRLRM-MILYTFLILCTLIFY--VLRTFGFFMMTLRISLRIHDQLFQGVIR 806
                    :|...|...|| |.:..|..:...:::  :..:..|.:::..:|:|...|.|:.::.
 Worm   796 --------VPYGGRMMHRMAMAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQSFRNLLY 852

  Fly   807 AFMHFF--TLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIW------- 862
            ....:|  .....|:::.|.:||...|...:...|:..| :|:.|:.....::....|       
 Worm   853 QDASYFDNPAHAPGKLITRLASDAPNIKAVVDARMLQVI-YALAAIIANIAIAFIYCWQIGILGT 916

  Fly   863 --LLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERD 925
              :|:.|.|::.|.|         ..||..:|.|.............:.:.||:.|.   ..|..
 Worm   917 SLILLLAFVMIGLAY---------KISLMNVEQIQNDDAGRIAIEIIENVKTIQLLT---RCELF 969

  Fly   926 FHYYQ----NENTSAL------YLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDV 980
            |.:||    .:..|.|      .::.|:.::|.::  ::|..|.:.:          |..|.||.
 Worm   970 FDHYQTSSKQQKRSELKKGMIEAINYSLTQSFMYF--MMCFTYAVGI----------RIIYQGDK 1022

  Fly   981 GLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPA------YETEESVNL----- 1034
            ....|....:.:|..|        ..:|.|.:...|:|...:...      |....:.:|     
 Worm  1023 SSDDTFKGIIAMMLGA--------VAVMNSAQYFPEFVKAKTAAGMLFNIIYRKPRTGDLMEGDR 1079

  Fly  1035 PKHWPSGGQLDFRDLRLRYSNHGPY--ILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHI 1097
            |:   ..|.:.|.:::..|... |.  |:|||.:|....:.:.:||.:.:|||:.:..|.|...:
 Worm  1080 PE---IRGNILFENVKFSYPQR-PLQPIMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDV 1140

  Fly  1098 -NGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNL-----DPFEEKTDEELWLALEAV 1156
             .|.:.|||.:..:|.|..||.:::::.|:|.||:|::|.|:     |...||.::    |||..
 Worm  1141 TGGALRIDGQDIRKLSLFHLRTQMALVGQEPRLFAGTIRENVCLGLKDVPLEKINQ----ALELA 1201

  Fly  1157 KLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEA 1221
            ....|::||..||:..:.:.|...|.||:|.:.:||||:|..|||::||||:.:|.|::..:|||
 Worm  1202 NANRFLANLPAGIDTDVGEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEA 1266

  Fly  1222 IHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEK 1278
            :.......|.:||||||.::.::|.::.:|.|:|.|.|:..:|:|.: |..::.::|
 Worm  1267 LDRAREGRTCITIAHRLSSIQNSDLIVYIDKGKVQEAGNHTQLMHQK-GRYYKLIKK 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11898NP_651679.2 CFTR_protein 9..1268 CDD:273530 296/1345 (22%)
ABC_membrane 92..358 CDD:294371 66/323 (20%)
ABCC_MRP_domain1 423..626 CDD:213217 58/216 (27%)
ABC_membrane 762..988 CDD:294371 47/249 (19%)
ABCC_MRP_domain2 1042..1261 CDD:213211 77/226 (34%)
pgp-14NP_510128.1 PTZ00265 104..1321 CDD:240339 290/1329 (22%)
ABC_membrane 109..377 CDD:279056 57/294 (19%)
ABC_MTABC3_MDL1_MDL2 429..666 CDD:213216 66/249 (27%)
ABC_membrane 769..1039 CDD:294371 56/312 (18%)
ABC_MTABC3_MDL1_MDL2 1086..1323 CDD:213216 80/243 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.