DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and pgp-8

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_509811.2	Gene:	pgp-8 / 181277	WormBaseID:	WBGene00004002	Length:	1243	Species:	Caenorhabditis elegans

Alignment Length:	1376	Identity:	294/1376 - (21%)
Similarity:	524/1376 - (38%)	Gaps:	403/1376 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGV---- 184
            :|...:|:.:||| .::.:|| ..|||.|.|           |.|.:.|:|::.|.:|:.:
Worm    33 SKWEKFLFVIGVV-SAICTGL-TQPFMSYTF-----------GEVSQAFVRITAAVNNASLDPSD 84

  Fly   185 ----------------------------------------------------------------- 184

Worm    85 LEKAYEMFHADMNNVVIHFGLVGCAFMFFGFIQFSLFKYIGDNTTYRLRHKFILRLLKKDAKYFD 149

  Fly   185 ---SGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFV---------------YIIYQLIGWPA 231
               :||..:::..:|..|.|:|.          |.:.|:               |..:.|..:.:
Worm   150 TISTGYLSTVLNDNLERFREAFN----------EKIAFIICFSTDFAIGTALAFYTSWTLASYGS 204

  Fly   232 VVGLGTIVA------------------FIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQ 278
            |...|.:::                  :....|.|.:|:..:|         .|..:|   ...|
Worm   205 VFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFK---------TVISLN---GQTQ 257

  Fly   279 LIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLSLVTYVFTG-DIV--- 339
            .::.|:.|....:..|..|...:.:.||.::.:    |..:..         |.::.| |::
Worm   258 ELEKYSAELKEGEKFGSRRAFFLATSRGLSHFF----CNALNG---------TILYVGADLIYNK 309

  Fly   340 TSQKVFIVASYY------DHLNDSLLH-SWPL-AINMWVETFVVANRVKDFLFQHENPADG---- 392
            |...|.||..::      ..|.::.|| |:.| |||.....|.|.....|.:   ||..|.
Worm   310 TMNTVAIVTLFHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVLTSDDDMI---ENNQDNEQTD 371

  Fly   393 ------GVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQA 451
                  |:.:|...:        |....:|..::                       :..:||..
Worm   372 SNKTIQGMLSFNNVK--------FAYPSRPDVDI-----------------------LRGISFDV 405

  Fly   452 QDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVN----------------GVLSYAPQEPWL 500
            :..:.:.:||..|:||||::|::|...:|.||::::.                ||:|   |||.|
Worm   406 KQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGVVS---QEPVL 467

  Fly   501 LRGSLRDNILFTEP-YDEQRYLEVLR-------VCHLDRDVEQLPLGDSTRVGEGGASLSGGQKA 557
            ...::.:||.|..| .......|.||       ||:: :|      |..|.|||.||.||||||.
Worm   468 FNTTIEENIRFGNPNATSSEIYEALRKANAYDFVCNI-KD------GLKTIVGERGAQLSGGQKQ 525

  Fly   558 RVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLL 622
            |:::||.:.:...|.|||:..||:|| .|:..:...|.:....:..|::.||:..:||.|.::::
Worm   526 RIAIARVLVKNPAILLLDEATSALDS-ASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVM 589

  Fly   623 EGGRISVQGHYDAL-------KKLIRFR----MSVANDV--EVAKLRAMRTDSVYEEPEPRKSLS 674
            ..|:|:..|.::.|       ..|:|.:    .||..|:  :.|:....:|.....:.||.:.|.
Worm   590 SNGKIAEVGSHEELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKTPPNLNDGEPLEELL 654

  Fly   675 QEEHMD---RHEIEQQFKE---------QQQIGS------------VKLQTYKEY------FKVL 709
            :|...|   :..|.:..:|         ...|||            :.:||||.|      ....
Worm   655 KETSSDIEIKSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTYKAYAMDGENILTY 719

  Fly   710 GHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCT 774
            ||....:.::|..:                                      |.:.||     |.
Worm   720 GHFWAAMFLVLGVI--------------------------------------RPITLY-----CQ 741

  Fly   775 LIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLA---------TSGRILNRFSSD--- 827
            ..|       |..::.::|.|:.       |::|.|..:|.         :..|::||.::|
Worm   742 FFF-------FGKVSEKLSTRLR-------IKSFQHLLSLPCAFYDDPKHSPTRLVNRLNTDPSN 792

  Fly   828 -VLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIW-LLIPATVVVALLYGCRCLYIGASRSLKR 890
             ..|:|..|...:|..:.|   :||:|  ::....| |.:...:...:||..:.||       |:
Worm   793 IKAAVDARLGSLLMSMVSF---SLAIL--IACYYSWKLTLQVVLFFPVLYYAKFLY-------KK 845

  Fly   891 IETIS---RSPIYSHTN----ATFKGLATIRALN-GTKYMERDFHYYQNENTSALYLHVSINRAF 947
            ..|||   .|..:.::|    .....:.|::||| ..:.:.....|.....||  |...|:....
Worm   846 TTTISIKEDSVAFENSNKIAIEVLDNMKTVKALNMEARVINLVMEYLAVLKTS--YPRRSVVMGL 908

  Fly   948 AFWTDLICVLYILAVTFSF---LLFDKH---RGYYSGDVGLAITQSMKLVLMCQAGMRQTVELEN 1006
            |......|...:.|::|.|   |:..|.   ...|...:.|:.|.:     |..:.:....:...
Worm   909 ANGFSAGCSQIVYAISFKFGTYLILQKEVIPMDMYLSLITLSYTSN-----MAGSAISYMPDFRK 968

  Fly  1007 MMTSVERVMEYVNIPSEPAYETEE-SVNLPKHWPSGGQLDFRDLRLRYSNHGPY-ILKGLTFTIR 1069
            .:.|...:......|:...:.::. |.::.|     |:::..:::..|.....| :|..:...:.
Worm   969 AIHSAGLIFNLFTYPATMPFNSDTGSRSITK-----GEVNGENVKFHYHQRPDYTVLDSVNLKVE 1028

  Fly  1070 GEEKIGIVGHTAAGKSSIVHAL--FRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSG 1132
            ..:.:.|||.:.:|||:|:..|  |..|. .|.|.||......:.|..||..:.::.|.||||:.
Worm  1029 AGKTLAIVGPSGSGKSTIISLLEMFYRAD-QGFIKIDNDNVENINLDHLRSNLGLVSQGPVLFNC 1092

  Fly  1133 SLRFNL--DPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALL 1195
            |:|.|:  ......:..|:..||:......||..|..|::..:.|.||..|.||:|.:.:.||:|
Worm  1093 SIRDNILYGLTRNISQTEIENALQIANAFNFVFQLPQGLDTIVGDRGAQLSGGQKQRIAITRAIL 1157

  Fly  1196 RQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGH 1260
            |..|:|::||||:.:|.|::.::|.|:.|.....:.:.:||||.|:::.|.:.|:..|:|||.|.
Worm  1158 RNPKLLLLDEATSALDTESEKIVQNALDTASERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGT 1222

  Fly  1261 PHELLHNRHGY 1271
            .::||..:..|
Worm  1223 HNQLLAVKGDY 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	293/1371 (21%)
		ABC_membrane	92..358	CDD:294371	52/348 (15%)
		ABCC_MRP_domain1	423..626	CDD:213217	63/226 (28%)
		ABC_membrane	762..988	CDD:294371	55/253 (22%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	70/223 (31%)
pgp-8	NP_509811.2	PTZ00265	29..1241	CDD:240339	294/1376 (21%)
		ABC_membrane	44..326	CDD:294371	48/329 (15%)
		ABC_MTABC3_MDL1_MDL2	382..617	CDD:213216	72/276 (26%)
		ABC_membrane	685..953	CDD:279056	65/338 (19%)
		ABC_MTABC3_MDL1_MDL2	1005..1240	CDD:213216	72/230 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000