DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and pgp-5

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001257116.1	Gene:	pgp-5 / 181276	WormBaseID:	WBGene00003999	Length:	1252	Species:	Caenorhabditis elegans

Alignment Length:	1363	Identity:	304/1363 - (22%)
Similarity:	536/1363 - (39%)	Gaps:	352/1363 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRK----------------- 171
            |::...|:.:|||. |:::|: ..||..|.....|:|.:.....:..|
Worm    30 TRYEKLLFFLGVVF-SILTGM-CQPFESYTLGETSQVLVKVTNAINNKTIDPVDLAHAYKLFESD 92

  Fly   172 -------------------FLRVSV---AADNSGVS---GYAISLMATDLPTF------------ 199
                               ||:.|:   ..||:..:   .|...|:..|:..|
Worm    93 MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTGHLSIVL 157

  Fly   200 NESFYCFHELWRGPLEGVV-----FV-------YIIYQLIGWPAVVGLGTIVAFIPLQAW----- 247
            |::...|.|::...:..::     ||       |..::|..:..|...|.:::.: |.:|
Worm   158 NDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVLSGL-LDSWGKMKN 221

  Fly   248 --------------AARAIARYKRSSADVGDERVKLMNEIIAAMQLIK---MYAWEKSFAKLIGK 295
                          |.:|:..||..|:..|.::     |:....:.:|   .||..::|...:.
Worm   222 NEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQ-----EVERYTEELKNGEKYALNRAFVFSLS- 280

  Fly   296 VRKEEMDSIRGSTYIYAGLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIV-----ASYYDHLN 355
                     |.:.|.:     |..::.:.|:.. ...::.|.|.....|.|:     .||.  |.
Worm   281 ---------RSADYFF-----TNALNFVILYFG-ANMIYEGTIEPGVVVRILYYILFGSYC--LG 328

  Fly   356 DSLLHSWPLAINMWVETFVVANRVKDFLFQHENPAD-----------GGVHNFKEAEDNPEHGNF 409
            :::||     |:.......:...:.|.|...:..||           .|:.:||..        .
Worm   329 EAILH-----ISRLASAIPLTVPIADILLDSDATADEFFSEEIKDTFQGIISFKNV--------L 380

  Fly   410 FGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVI 474
            |....:|...|                       ::::||..|..:.:.:||..|:||||::|::
Worm   381 FSYPTRPDVPV-----------------------LKEISFNVQGGECIALVGASGSGKSTVIQLL 422

  Fly   475 LGELDIISGSVEVNG-------------VLSYAPQEPWLLRGSLRDNILFTEP-YDEQRYLEVLR 525
            |...:|.||.:.::|             .:....|||.|...|:.:||.|.:| ..||..::.|:
Worm   423 LHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKPDATEQEIIDALK 487

  Fly   526 VCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLL 590
            ..:....|...|.|..|.|||.||.||||||.|:::||.:.|...|.|||:..||:|:. |:.::
Worm   488 NANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATSALDNE-SEFIV 551

  Fly   591 DRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKL 655
            ...|.:....:..|:|.||:..:|:.:.::::|.|.|...|.:   |:||... .|.|::...:|
Worm   552 QEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDH---KQLIAMN-GVYNNLVQTQL 612

  Fly   656 RAMRTDSVYEEPEPRKSLSQEEHMD--RHEIEQQFKEQQQ------IGSVKLQTYKE-------- 704
            .:...:.:.|..|  :...|..|.|  .:||..|..:|:.      |..:|.:..|:
Worm   613 MSTNYEKMNENEE--RVTRQSSHSDFPSNEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIK 675

  Fly   705 ---------YFKVLG-------HPLVVVLILLMFVVARSSEA---TMDIFLSKWATWEETEPNQH 750
                     :..|||       :||...|::      :|.||   ..|..|||...|
Worm   676 YCRSEYCILFIAVLGSAIQGIYYPLSSQLMI------KSYEAYAFDKDEMLSKSHFW-------- 726

  Fly   751 EPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLA 815
                       .:.||:........||:....||.....|.|.||         ..:|.|..:|.
Worm   727 -----------ALSILFLAFTRPIFIFFQYYFFGKTAEKLSIKLR---------SMSFKHLMSLP 771

  Fly   816 ---------TSGRILNRFSSD----VLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPA 867
                     |:.|:.||.::|    ..|:|..|...:|..:     |:.:..::|....|
Worm   772 CAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLV-----AILLAVIMSFFYSW----- 826

  Fly   868 TVVVALLYGCRCLYIG-------ASRSLKR----IETISRSPIYSHTNATFKGLATIRALNGTKY 921
            .:.:.:|..|..||:.       ..::::.    .|..:|:.|.:..|     :.|:||||
Worm   827 KMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALEN-----VRTVRALN---- 882

  Fly   922 MER------DFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSF----------LLFD 970
            ||.      ..|..:..|:   |...::.:..|......|..:|.||:|.|          |..|
Worm   883 MENRVILLVTSHLQKIRNS---YFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMD 944

  Fly   971 KH--------RGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYE 1027
            .:        ...|:|.....:....|.:  ..||:               :......|:...|:
Worm   945 TYLVLMTLSMTASYAGSAVAYLPDHRKAI--HAAGL---------------IFHLFTYPAIMPYD 992

  Fly  1028 TEESVNLPKHWPSGGQLDFRDLRLRYSNHG-PYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHAL 1091
            :.:.    |.....|:::.:::...|:... ..||.|::..:.....:.:||.:.:|||:|:..|
Worm   993 SSQG----KRNIKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLL 1053

  Fly  1092 FRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFN-LDPFEEKTDE-ELWLAL 1153
            .|..| ::|.:.||......:.||.||..:|::.|:||||:.|::.| |........: |:..||
Worm  1054 ERFYHAVDGEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQAL 1118

  Fly  1154 EAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLI 1218
            :......|||....|::..:.:.||..|.||:|.:.:|||:||..|:|::||||:.:|.:::.::
Worm  1119 KVANAFSFVSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVV 1183

  Fly  1219 QEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGV 1281
            |.|:.|.....:.:.:||||.||::.|.:.|:..|:|.|.|...|||..|..| .|.|:|.|:
Worm  1184 QNALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIY-WRLVQKQGI 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	298/1348 (22%)
		ABC_membrane	92..358	CDD:294371	55/326 (17%)
		ABCC_MRP_domain1	423..626	CDD:213217	62/216 (29%)
		ABC_membrane	762..988	CDD:294371	54/273 (20%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	70/222 (32%)
pgp-5	NP_001257116.1	PTZ00265	27..1241	CDD:240339	301/1357 (22%)
		ABC_membrane	41..322	CDD:294371	49/304 (16%)
		ABC_MTABC3_MDL1_MDL2	374..611	CDD:213216	75/272 (28%)
		ABC_membrane	688..955	CDD:294371	66/322 (20%)
		ABC_MTABC3_MDL1_MDL2	1005..1243	CDD:213216	76/238 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000