Protein Alignment CG11898 and pgp-10

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_509205.2
• Gene: pgp-10 / 180981
• WormBaseID: WBGene00004004
• Length: 1382
• Species: Caenorhabditis elegans
• Alignment Length: 1474
• Identity: 320/1474 - (21%)
• Similarity: 578/1474 - (39%)
• Gaps: 351/1474 - (23%)

  Fly    32 VKGLQRNLDPSDLY--ETEPSLESTQVSSFLLGHWEQELKRSKPNVLRM-IFKAYGWSFVPA-SI 92
            :|.:...::||.||  :.:.|.::..|:      .:..|.:|..:..:: .|:.|...:..| ||
 Worm    34 LKSMIYPIEPSTLYIDDLKNSKKAYDVT------MDDPLDKSSDSKPKLGFFEPYKRLYAFADSI 92

  Fly    93 VYSIMAIAVHTT------QP---LMLGGLVSF-FSESTGKI--------------TKHS---AYL 130
            ...:||:.:.:.      .|   |::|..||. .....||:              ..||   |::
 Worm    93 DMQLMAMGLFSALLQSALPPFVWLIMGNFVSISILREEGKLGLKNLTSDYPIDDQFAHSATPAFI 157

  Fly   131 YAMGVVLCSLISGLFFHPFMKYLFRVGS-----RVRLACAGLVYRKFLRVSVAADNSGVSGYAIS 190
            ..:|:.:...|:..    ..:..:.:.|     |::.|    ..||.|.:.::...|..||:..:
 Worm   158 SMLGLSIAMFIAAF----CQRIAWEISSIRQVFRIKKA----YIRKLLLMDISWLESRQSGHVAA 214

  Fly   191 LMATDLPTFNESFYCFHELWRGPLEGVVFV--YIIYQL-----IGWPAVVGLGTIVAFIPLQAWA 248
            ::       .||....:......|..|||:  |::..:     |.|.  |.|...:| |||
 Worm   215 ML-------QESADSIYNGISDHLPMVVFILSYLLVNIGVCLYIQWD--VTLFMCLA-IPL---- 265

  Fly   249 ARAIAR--YKRSSADVGDERVKLMNEIIAAM-QLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYI 310
             ..|:|  |.:..|:..:|..||.|:|...: :.........|||....|:.|.|..|...|...
 Worm   266 -LIISRILYSKWFANTMEEETKLQNKITNLVNETFNCITTVISFAAQKQKINKFEKLSAEHSKLT 329

  Fly   311 YAGLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVV 375
            ...|:.:.:...|:..| |...:|||.:...  ::.||      ::|......|||||   .::.
 Worm   330 EERLRSSVVFDSLTQIL-LTELIFTGALCYG--IWRVA------DNSPGRLCALAINM---LYMC 382

  Fly   376 ANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITV--------------- 425
            ...:.  :..|.|.|.....|.||..:        ....:||.||:..::
 Worm   383 VTSIS--IGFHMNGATRAKDNAKEICE--------VLNEQPKIEVELASIDNNIDYVPVTRCKYR 437

  Fly   426 --------------HKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILG 476
                          ..:..|:..:|:.:   .:..:||:.:..:.:.|||:.|:|||||..::|.
 Worm   438 RQSMKFMGKGALHFRDIHFSYPSRKETE---VLRGISFKVEAGEKIAIVGSSGSGKSTLTALLLR 499

  Fly   477 ELDIISGSV-------------EVNGVLSYAPQEPWLLRGSLRDNILFTE-PYDEQRYLEVLRVC 527
            ..|...|::             ::.|..|...|||.|..|::.|||.:.. ...:|...:..|..
 Worm   500 FYDPTKGAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGTISDNIRYGRLDATQQEINDAARKV 564

  Fly   528 HLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDR 592
            ...:.:..||.|..|||||.|..||||||.||::||||.||..:.:.|:..||:| ::.:..::.
 Worm   565 GAWKFINSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRKPIVLIFDEATSALD-NIHEEEVNA 628

  Fly   593 CLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRA 657
            .::........|.:.||:..:::.|.:::|..|:|..:|..|.|       ::.||.:.......
 Worm   629 AIDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPDEL-------IADANGIFHKMYND 686

  Fly   658 MRTDSVYEEP-------------EPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKL-QTYK----- 703
            .|.|.:.::.             :.:.|.|...:||..:..:.:......|:.|| ::|.
 Worm   687 QRLDQLTQQHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARSSLGGNKKLGKSYSVNSME 751

  Fly   704 -------------------EYFKV------------------------------------LGHPL 713
                               :|.||                                    .|.||
 Worm   752 KEKLKLPVMSKKKSERLDYKYSKVHSMDVKQHTDSMHDDDDLPGKETNFTVLKDLIYSYRTGLPL 816

  Fly   714 V-----------VVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMI-- 765
            :           |..:|:.|.||    :.::|.::                |:..|. |::.|
 Worm   817 LAGAIPTTIVRAVFYLLICFQVA----SVLEISIA----------------PDEERA-LQIFIVA 860

  Fly   766 -LYTFLILCTLIFYVL-RTF------GF--FMMTLRISLRIHDQLFQGVIRAFMHFF--TLATSG 818
             :||.||:...||..| |.|      ||  ||         .:::|:.|:|....:|  ...:.|
 Worm   861 AIYTALIIVKTIFEALGRIFIALYGHGFCKFM---------RNEMFRKVLRHGAAYFDEERNSPG 916

  Fly   819 RILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWL----------LIPATVVVAL 873
            |::::    |:.....|.:.|...::..:..:..........:|:          ..||..|:.:
 Worm   917 RLVHK----VINESSTLNEIMEQKLDMLIPGVVCSLFSIVCALWINWKMALLCSFQFPAYFVIRI 977

  Fly   874 LYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQ-----NEN 933
            |.    :..|..|..:.::...::.  :..:.....::||:|.|      ...|:|.     .:.
 Worm   978 LQ----IREGTKRQRQMVDEEKKAA--NLASVVLANMSTIKAYN------LQSHFYNVFCDALKP 1030

  Fly   934 TSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDV-----GLAITQSMKLVLM 993
            .|......|:..|..|.........::|:|..|           |.|     .:::...|::||:
 Worm  1031 VSQCMQKQSLISALVFACQYSFTYILIAITLHF-----------GKVMMLANEISVFDYMRVVLL 1084

  Fly   994 CQAG-------MRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRL 1051
            .|.|       :....:......:.|.||..:..|........|....||   ..|.|..:|:..
 Worm  1085 TQFGANFFSQLIASVSDFTKAQIAAENVMRVIREPPVDMDNLSEEGLRPK---LEGNLCLKDVSF 1146

  Fly  1052 RYSNHGPY--ILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGL 1113
            ||.:. |.  :|..|...:||.|.|.:||.:.:||||::....|:.: .:|.:.||.:....:..
 Worm  1147 RYPSR-PIVPVLTNLNLKVRGGESIALVGPSGSGKSSVISLFQRMYNATDGVVIIDKYNIKSINP 1210

  Fly  1114 HDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKE---FVSNLKDGINCRLHD 1175
            ..|||.|..:.|:|.|||.:::.|:.....:::..:...:||.|:.:   |:::|..|.:..:.:
 Worm  1211 AYLRRCIVQVGQEPDLFSFTIKENIAFGMMESEATIDKVIEAAKIADIHNFITSLPQGYDTEVGE 1275

  Fly  1176 CGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIH-----TKFAHCTVLTIA 1235
            .||..|.||:|.:.:|||::|:..:|::||||:.:|..::..:|.|..     || ..||.:.||
 Worm  1276 FGAQLSGGQKQRIAIARAIIRKPTVLLLDEATSALDSASEREVQNAFERVKRSTK-TQCTCIQIA 1339

  Fly  1236 HRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKT 1279
            |||.|:.:.|::.|:..|.:.|.| .||.|.|..|..:...:.|
 Worm  1340 HRLSTIRNVDKIYVIVHGEIAEEG-SHEQLINLKGIYYEMNQMT 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	317/1461 (22%)
		ABC_membrane	92..358	CDD:294371	65/307 (21%)
		ABCC_MRP_domain1	423..626	CDD:213217	60/245 (24%)
		ABC_membrane	762..988	CDD:294371	45/259 (17%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	71/229 (31%)
pgp-10	NP_509205.2	MdlB	73..687	CDD:224055	152/669 (23%)
		ABC_membrane	156..381	CDD:294371	58/259 (22%)
		ABC_MTABC3_MDL1_MDL2	450..687	CDD:213216	67/247 (27%)
		ABC_membrane	823..1099	CDD:294371	59/332 (18%)
		MdlB	825..1382	CDD:224055	142/619 (23%)
		P-loop_NTPase	1141..1381	CDD:304359	74/242 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000