DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and mrp-6

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001362008.1	Gene:	mrp-6 / 180691	WormBaseID:	WBGene00003412	Length:	1415	Species:	Caenorhabditis elegans

Alignment Length:	1420	Identity:	437/1420 - (30%)
Similarity:	704/1420 - (49%)	Gaps:	191/1420 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FSKWFFIWTREILVKGLQRNLD-PSDLYETEPS-----------LESTQVSS------FLLGHWE 65
            ||...|.|.|       .||.. .:||.| :||           |||..:||      ||:|.|.
Worm    59 FSFVGFYWWR-------TRNAQTDTDLLE-KPSKGISAKYAAQKLESKWISSGPKRTHFLVGVWH 115

  Fly    66 QELKRSKPNVLRMIFKAYGWSFVPASIVYSIMAIAV--------HTTQPLMLGGLVSFFSESTGK 122
                                     ....|:||.|:        ...|||:|..|:|::....|:
Worm   116 -------------------------CTKVSVMAHAISLCLEELTRVAQPLLLRELMSYYDIEEGQ 155

  Fly   123 ITKH-SAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSG 186
            ...: .|...|:.:.|.|.::....||:...|.:||:..|:|...|:|||.||:|:.:.....||
Worm   156 EFPYWPAMQVALIISLLSFVTVCIHHPYFHGLLKVGNHARVATGVLLYRKSLRISLTSLFETNSG 220

  Fly   187 YAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARA 251
            ..|.|:.||.....::|...|.:|..||....:.||::.:.|:..::|...::|.:..|...:..
Worm   221 QIIQLLNTDAAKLEQAFLFAHYVWLCPLLMFFYAYILWSMFGFCCLLGFLVMMAIVSFQVHYSYQ 285

  Fly   252 IARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQC 316
            :...:|:..|..|.|:|:|:|||..:::|||:.||.:||:.|..:|::|:.:: |::..|:.: .
Worm   286 LGVNRRNIGDKMDSRLKVMSEIINGIKVIKMHGWENAFAEKIRILREDEIKAV-GTSAFYSSM-V 348

  Fly   317 TGMI---SKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANR 378
            .|:.   :|:.||:.:....:..:|:|::.||..::.::.:........||.:....|.|..:.|
Worm   349 MGIYFISAKIGLFVYIFACDYFDEILTTRGVFASSALFNSVRLPFALFLPLGLLFGRELFSTSRR 413

  Fly   379 VKDFLFQHE----------NPADGGVHNFKEAEDNPEHGNFFGRTHKP-------KAEVKSITVH 426
            :..|....|          ...:.|..|.||.....:.|      .||       |||..|:.::
Worm   414 IDLFFCLEEYSRITLELDSTDTEDGSKNEKEGLTLKKIG------EKPSWTLKCDKAEKTSVFLN 472

  Fly   427 KLSASW------DQKKQEKRHRHIED----------------VSFQAQDQQF-------VGIVGT 462
            |::|.|      ||||::|..:.:.|                |.:..||..|       .||:|:
Worm   473 KVTAVWYDKDEHDQKKKKKNFKALSDNDATVIAGEKKDEPLHVVYAVQDLSFEFVAGTCYGIIGS 537

  Fly   463 VGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVC 527
            ||:|||:||..||.|..:..|::.|||..:|..||||:..||::|||:|...::::||...|.:|
Worm   538 VGSGKSSLLLTILSESRMTRGNLSVNGSFAYCAQEPWIFTGSIQDNIVFGSEFNKERYENALELC 602

  Fly   528 HLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDR 592
            .|..|:.|...||.|.||:.|::|||||:|||:||||||..||||||||||||||:||.|.|.:.
Worm   603 LLTPDLRQFANGDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGKKLYEN 667

  Fly   593 CLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALK--------KLIRFRMSVAND 649
            .:..|||.|:.|||||::..|..:|.::|::..::...|..|.||        ||......|.:|
Worm   668 LIRGFLSDKLVILVTHQIHFLSELDSVILMKNNKMVGNGSLDELKSTFTDDFIKLQAVETEVQSD 732

  Fly   650 ---------------VEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKL 699
                           |.:..:..:..:|:::  .....||..:..:...:::...|.::.|::..
Worm   733 ELFVDGPPSSPPPSPVNIESMEKINKESIFQ--RANSVLSGSKMSETEYVKEIVYESRKSGTISW 795

  Fly   700 QTYKEYFKVLGHPL-----VVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRT 759
            ..|.||.:.:.:||     :||.:|    :.:.....:|.:|:||..  :.:.|..:........
Worm   796 SVYWEYTRGVINPLKYGIWLVVCVL----ITQLMNNFVDWWLNKWLV--DLDMNNADNSTSKEEF 854

  Fly   760 RLRMMIL-YTF----------LILCTLIFYVL---RTFGFFMMTLRISLRIHDQLFQGVIRAFMH 810
            ...:.:| |||          .|:.|:|..:|   |:..|....|..|..:|:.:|..|::....
Worm   855 NRNVDVLGYTFNVTFQTYELTFIISTVIMSILGVVRSVWFRNAQLMASRILHNSMFDCVLKTESE 919

  Fly   811 FFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLY 875
            ||...:.|.||||||.|:...|..|.....:.:...:..:.::.:||.....:::....:.|..|
Worm   920 FFDKNSEGMILNRFSKDIGLTDDLLAFTYFEFVFGTLTFVGIVGLVSMVRPIVILACAFITAGFY 984

  Fly   876 GCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLH 940
            .||.:|:..||.|||||..:|||:.:...:|..||:||||......|...|....:...:|..:.
Worm   985 FCRKMYVHRSRELKRIEAAARSPLNTTITSTVHGLSTIRAYRKENEMIEKFCALHDVYMAAYNMG 1049

  Fly   941 VSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELE 1005
            :...|.|....|.:..:::..|....:|  ::.....|:|||.:..:::|.......|||:.|||
Worm  1050 LLSARWFGICIDFLVSVFVSIVAIVVVL--QYETLTVGEVGLCLVCAVQLSGFFSWIMRQSAELE 1112

  Fly  1006 NMMTSVERVMEYVNIPSE-------PAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKG 1063
            |.|.|||||:||..:.||       .||..::.:|   .||:.|:::|.::.:.|..  ..:||.
Worm  1113 NGMVSVERVLEYTKLKSEEEARRPHDAYLDKQLLN---SWPTKGEIEFENVSVNYGE--TKVLKN 1172

  Fly  1064 LTFTIRGEEKIGIVGHTAAGKSSIVHALFRL-AHINGHISIDGFETSQLGLHDLRRRISIIPQDP 1127
            |:|.:.|.:|||:||.|.||||:::..:|.| .:.:|.::|||.:...:.|:..|..:|||||:|
Worm  1173 LSFVVLGGQKIGVVGRTGAGKSTLIKIIFGLKEYCSGRVTIDGVDLDHISLNFRRGGMSIIPQEP 1237

  Fly  1128 VLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLAR 1192
            |:|||::|.|||||:|..|..:|.|||..:||..::..| |:|..|...|.:.|:|||||.||||
Worm  1238 VIFSGTVRENLDPFDEYDDATIWFALEQCELKRSITKEK-GLNVELGQRGVSLSVGQRQLFCLAR 1301

  Fly  1193 ALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVE 1257
            |::.::|||::||||||||..||..||:.|...|.:.|::|:||||||:|::|.|||.:.|.:||
Worm  1302 AMIHRSKILVIDEATANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNSDNVMVFEKGELVE 1366

  Fly  1258 LGHPHELLHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKRVLGRKSEDQGSVLD 1312
            ...|..||.::.....|...::|......||..|        |....:||.|..|
Worm  1367 FDKPITLLDDQSSLFSRMAAQSGAENFDSLRAAA--------LAHAIDDQSSYTD 1413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	427/1374 (31%)
		ABC_membrane	92..358	CDD:294371	75/277 (27%)
		ABCC_MRP_domain1	423..626	CDD:213217	98/231 (42%)
		ABC_membrane	762..988	CDD:294371	63/239 (26%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	99/219 (45%)
mrp-6	NP_001362008.1	MRP_assoc_pro	<126..1389	CDD:188098	403/1286 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I2739
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820