DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11898 and mrp-1

DIOPT Version :9

Sequence 1:NP_651679.2 Gene:CG11898 / 43451 FlyBaseID:FBgn0039645 Length:1320 Species:Drosophila melanogaster
Sequence 2:NP_001024719.2 Gene:mrp-1 / 180409 WormBaseID:WBGene00003407 Length:1534 Species:Caenorhabditis elegans


Alignment Length:1378 Identity:425/1378 - (30%)
Similarity:704/1378 - (51%) Gaps:160/1378 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 PVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYE-TEPSLESTQVSSFL------LGHWEQELK 69
            |...|:|.::..|.|...:...|.:::|:..||:: .|.......:.||:      :..:.:::|
 Worm   208 PEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIK 272

  Fly    70 --------RSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKH 126
                    ::.|::|..|||.|.::.: |...|.:|...:....|.:|..|:||..:....:  .
 Worm   273 KNPEAAIPKNHPSILIPIFKTYKFTLL-AGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPM--W 334

  Fly   127 SAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISL 191
            .....|:.:.|.||:..:..|.:...:||:|..:|......||.|.|.:|..|.....:|..::|
 Worm   335 IGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNL 399

  Fly   192 MATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYK 256
            |:.|:....:........|..||:.::.:|.:::|:|...:.|...::..||..::.:..:...:
 Worm   400 MSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQ 464

  Fly   257 RSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGL----QCT 317
            .......|||:|:|:||:..|:::|:|:||||..|::.:||::|:..::..:|:.|..    .|.
 Worm   465 MEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACA 529

  Fly   318 GMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAI-----NMWVETFVVAN 377
            ..:..:..|...|.:....:::|.|..|:..:.::.|.      :|||:     :..|:......
 Worm   530 PFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILR------FPLAVFAMVFSQAVQCSASNT 588

  Fly   378 RVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHR 442
            |:|:|              |...|.:|:....:|.|.      .:|.:...|.:|..|:::   |
 Worm   589 RLKEF--------------FAAEEMSPQTSIAYGGTD------SAIKMDGGSFAWGSKEED---R 630

  Fly   443 HIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRD 507
            .:.|::|..:..|.|.|||.||:|||:||..:|||::.:||||:|||.::|.||..|:...|||:
 Worm   631 KLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRN 695

  Fly   508 NILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIY 572
            ||||..|||.:.|..|:..|.|.:|:|.||..|.|.:||.|.:||||||.|||||||||:.|:|.
 Worm   696 NILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIV 760

  Fly   573 LLDDPLSAVDSHVSKMLLDRCLNE---FLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYD 634
            |||||||||||||.|.:.:..::.   .|..|.|:|:||.:..|:|.|.:::|:...||..|.|.
 Worm   761 LLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQ 825

  Fly   635 -------------------------------------------------ALKKLIRFRMS----- 645
                                                             |:::.|:.:||     
 Worm   826 ELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEK 890

  Fly   646 --------VANDVEVAKLRAMRTDSVYEEPE-------PRKSLSQEEHMDRHEIEQQFKEQQQIG 695
                    :.|.:...:..|..:....||.|       |::...:.....:.::.:  ||..:.|
 Worm   891 TDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIE--KEAVETG 953

  Fly   696 SVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTR 760
            .||.:.|..||:.:|..:.:| ..|::|.:.......:::|::|:  ::.:............|:
 Worm   954 KVKFEVYMSYFRAIGIKIALV-FFLVYVASSMLGVFSNLYLARWS--DDAKEIALSGNGSSSETQ 1015

  Fly   761 LRMMILYTFL------ILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGR 819
            :|:.| |..|      .:|..  .::...|.    :..|..:|..|.:.::|:.|.||.:...||
 Worm  1016 IRLGI-YAVLGMGQATSVCAA--SIIMALGM----VCASRLLHATLLENIMRSPMAFFDVTPLGR 1073

  Fly   820 ILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTAN---IWLLIPATVV--VALLYGCRC 879
            |||||..||..:|.::|:.|...|..||:::.::|::..|.   |.||:|..:|  |.|.:    
 Worm  1074 ILNRFGKDVDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRF---- 1134

  Fly   880 LYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSIN 944
             |:..||.|||:|:.||||||||...:.:|.::|||........|:..:..:||.:..|..:..|
 Worm  1135 -YVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVAN 1198

  Fly   945 RAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMT 1009
            |..|...:::..|.:|:...:.:.|....|..:|.|||:::.::.:.......:|.|.|||..:.
 Worm  1199 RWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIV 1263

  Fly  1010 SVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKI 1074
            :|||:.||...|:|.  ...:|: .||.||..|::..::..:||......:|.|:|..|...|||
 Worm  1264 AVERINEYTITPTEG--NNSQSL-APKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKI 1325

  Fly  1075 GIVGHTAAGKSSIVHALFRLAHINGH-ISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNL 1138
            ||||.|.|||||:..||||:...:|. |.|||...:.|.|..||.|::|:|||||||||::|.||
 Worm  1326 GIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNL 1390

  Fly  1139 DPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIM 1203
            |||...:|:::|.||....|..||.:|::|::..:.:.|.|.|:|||||:||||||||:.|:|::
 Worm  1391 DPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVL 1455

  Fly  1204 DEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNR 1268
            |||.|.||.|||:|:|:.|..:|..||||||||||:||||:||::|:|.|.|.|...|.:||.|.
 Worm  1456 DEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNP 1520

  Fly  1269 HGYLHRFVEKTGV 1281
            .|..:...:...|
 Worm  1521 DGIFYSMAKDANV 1533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11898NP_651679.2 CFTR_protein 9..1268 CDD:273530 422/1363 (31%)
ABC_membrane 92..358 CDD:294371 62/269 (23%)
ABCC_MRP_domain1 423..626 CDD:213217 97/205 (47%)
ABC_membrane 762..988 CDD:294371 71/236 (30%)
ABCC_MRP_domain2 1042..1261 CDD:213211 111/219 (51%)
mrp-1NP_001024719.2 MRP_assoc_pro 23..1531 CDD:188098 424/1374 (31%)
ABC_membrane 309..570 CDD:294371 60/268 (22%)
ABCC_MRP_domain1 614..815 CDD:213217 97/203 (48%)
ABC_membrane 976..1248 CDD:279056 76/285 (27%)
ABCC_MRP_domain2 1293..1513 CDD:213211 111/219 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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