DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and mrp-2

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_508121.1	Gene:	mrp-2 / 180408	WormBaseID:	WBGene00003408	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1385	Identity:	430/1385 - (31%)
Similarity:	678/1385 - (48%)	Gaps:	163/1385 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYE-TEPSLESTQVSSFL----- 60
            |.:::.....|...|:|.::..|.|...:...|.:::|:..||:: .|.......:.||:
Worm   198 SDMYKSESSCPEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENLIPSFMQNLKP 262

  Fly    61 -LGHWEQELK--------RSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFF 116
             :..:.|.:|        ::.|:.:..|||.|.::.: |...|.:....:....|.:|..|:.|.
Worm   263 RIDEYHQNIKKDPSAALPKNHPSFVIPIFKTYKYTLL-AGFFYKLCFDMLQFLAPQLLKQLIGFI 326

  Fly   117 SESTGKITKHSAYLYAMGVV----LCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSV 177
            .:      |:........:|    ..|.:..:|.|.:...:||:|..||......||.|.|.:|.
Worm   327 ED------KNQPVWIGCSIVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSN 385

  Fly   178 AADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFI 242
            .|......|..::||:.|:....:........|..||:..:.:|.:::.:|..|:.||..::..:
Worm   386 EARKGKTIGAIVNLMSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILAL 450

  Fly   243 PLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGS 307
            |:....|..:.:.:.....:.|||:|:|:||:..|:::|:|:||:|...::.|:|:.|:..::..
Worm   451 PVNGLIAIQMRKCQTEQMKLKDERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKL 515

  Fly   308 TYIYAGLQCTGMISK-LSLFLSLVTYVF---TGDIVTSQKVFIVASYYDHLNDSLLHSWPLAI-- 366
            :|..|.:..:.:.:. |:..:|.|.||:   ..:::|.:..|:..|.:|.|.      .|||:
Worm   516 SYFMAAIVFSWICAPFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILR------MPLAMVA 574

  Fly   367 ---NMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKL 428
               ...|:..|...|:|:|              |...|.:|:.....|.|.      .:|.|...
Worm   575 MVYGEAVQCSVSNTRLKEF--------------FAAEEMSPQTSISHGETD------SAIEVENG 619

  Fly   429 SASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSY 493
            ..||...:...    :.::||:.|..|.|.|||.||:|||:||..:|||::.:||||::||.::|
Worm   620 LFSWSSDEDPT----LREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAY 680

  Fly   494 APQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKAR 558
            .||:.|:...|||:||||.:|||.:.|.:|::.|.|..|:..||.||.|.:||.|.:||||||.|
Worm   681 VPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQR 745

  Fly   559 VSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE---FLSKKIRILVTHRVQLLRHVDHLV 620
            ||||||||:..||.|||||||||||||.|.:.:..::.   .|:.|.|:||||.:..|:|.|.|:
Worm   746 VSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCDQLI 810

  Fly   621 LLEGGRISVQGHYDAL------------------------------------------------- 636
            :|:.|.||..|.|..|
Worm   811 VLKEGTISELGTYQELLNNSGAFAEFLEEFLIEESKTRGRVASIGDGSGEVDEILRDLGQVKPGI 875

  Fly   637 KKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQF------------- 688
            .|.:...:|..:|.|....||:.    |.....|:|:.......:||..:..
Worm   876 LKRLESHLSQESDKEDTSARAIE----YSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQEN 936

  Fly   689 -----KEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPN 748
                 ||..:.|.||.:.|..||:.:..| :.:|...::|.:.......:.:|:|.        :
Worm   937 TQLIEKETVETGKVKFEVYIAYFQAISIP-ITLLFFFLYVGSSGLGILSNFYLAKL--------S 992

  Fly   749 QHEPIPEYHRTRLRMMI-LYTFL----ILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAF 808
            .|........:..:|.: :|..|    ....||..::.|.|    .||.|..:|..|...::|:.
Worm   993 DHAKSGNRTSSDAKMELGIYAVLGMGQSFVVLIASIILTIG----VLRASRILHAGLLGNIMRSP 1053

  Fly   809 MHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVAL 873
            |.||.:...||||||...|:.|||..||..:........|.:|.|.|:..|..|..|...::..:
Worm  1054 MAFFDVTPIGRILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVI 1118

  Fly   874 LYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALY 938
            .:.....||..||.|||:|:.||||||||...:.:|.::|||........:......:::..|.|
Worm  1119 YFIVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYY 1183

  Fly   939 LHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVE 1003
            ..:..||..|...:::..|.:|:...:.:.|....|..:|.|||:::.::.:.......:|.|.|
Worm  1184 PSIVANRWLAVRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSE 1248

  Fly  1004 LENMMTSVERVMEYVNIPSEPAYETEESVNL-PKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFT 1067
            ||..:.||||:.||...|:    |...|..| .|.||..|::..::..:||......:|.|::..
Worm  1249 LETNIVSVERIKEYTVTPT----EGNNSRRLAAKSWPEKGEISIKNFSVRYRPGLDLVLHGISAH 1309

  Fly  1068 IRGEEKIGIVGHTAAGKSSIVHALFRLAHIN-GHISIDGFETSQLGLHDLRRRISIIPQDPVLFS 1131
            |...||:||||.|.|||||:..||||:...: |.|.|||...:.|.|..||..::|:||||||||
Worm  1310 IAPSEKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFS 1374

  Fly  1132 GSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLR 1196
            |:::.|||||...:|.::|.|||...||.||.:|:||:..::.:.|.|.|:|||||:||||||||
Worm  1375 GTMKMNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLR 1439

  Fly  1197 QNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHP 1261
            :.|:|::|||.|.||.|||:|||:.|..:|..||||||||||:||||:||::|:|.|||.|...|
Worm  1440 KTKVLVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSP 1504

  Fly  1262 HELLHNRHGYLHRFVEKTGV 1281
            ..||.|..|..:...:...|
Worm  1505 KNLLANPDGIFYSMAKDANV 1524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	426/1363 (31%)
		ABC_membrane	92..358	CDD:294371	63/273 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	98/205 (48%)
		ABC_membrane	762..988	CDD:294371	68/230 (30%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	112/219 (51%)
mrp-2	NP_508121.1	MRP_assoc_pro	25..1522	CDD:188098	429/1381 (31%)
		ABC_membrane	309..570	CDD:294371	62/272 (23%)
		ABCC_MRP_domain1	614..816	CDD:213217	98/205 (48%)
		ABC_membrane	971..1239	CDD:279056	72/279 (26%)
		ABCC_MRP_domain2	1284..1504	CDD:213211	112/219 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720