DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and mrp-7

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_507812.3	Gene:	mrp-7 / 180289	WormBaseID:	WBGene00003413	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1376	Identity:	430/1376 - (31%)
Similarity:	689/1376 - (50%)	Gaps:	177/1376 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQ--ELKRSK- 72
            :|..:::|.::....|...|...|.:|:|:..|::|    |.....:.||...||.  |.||.|
Worm   207 SPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFE----LNERSGTEFLSELWESFWEPKRLKY 267

  Fly    73 ----------------------PNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSF 115
                                  |:|:..:|..:.|.|:.||.: ..::..:....|.:|..|::|
Worm   268 IHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTL-KFVSDTMQFASPFLLHELLNF 331

  Fly   116 FSESTGKITKH---SAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSV 177
            .|.......|.   |..::::..:...:::|.|:     .:||:|::::.:....||:|.|.:|.
Worm   332 ISAKNAPFWKGMALSILMFSVSELRSLILNGYFY-----IMFRMGTKIQTSLTAAVYKKTLLISN 391

  Fly   178 AADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFI 242
            :|......|..::|||.|:..|........:.|..|.:....:..::..:|:.|:.|:..:|.|:
Worm   392 SARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMVIFV 456

  Fly   243 PLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGS 307
            |:...::..:.:::.....:.|||.|::||::..::::|:||||......|.::|.:|:..|:.|
Worm   457 PMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELALIKKS 521

  Fly   308 TYIYAGLQCTGMISK--LSLFLSLVTYVFT--GDIVTSQKVFIVASYYDHLNDSLLHSWPLAINM 368
            ..:...|......|.  ::|| |..|:|.:  ..::|.|..|:..:.::.|. |.:....|.||.
Worm   522 AMVRNILDSFNTASPFLVALF-SFGTFVLSNPSHLLTPQIAFVSLALFNQLR-SPMTMIALLINQ 584

  Fly   369 WVETFVVANRVKDFLFQH---ENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSA 430
            .|:..|...|:|:||...   |...|..|:              ..|:|      .::.|..|:|
Worm   585 AVQAVVSNKRLKEFLVAEELDEKCVDRSVN--------------IERSH------NAVRVENLTA 629

  Fly   431 SWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAP 495
            ||| .::....:.::||...|.....:.:||.||:|||:|||.:|||:..:.|.:.|||.::|.|
Worm   630 SWD-PEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLRGRIGVNGRVAYVP 693

  Fly   496 QEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVS 560
            |:||:...:|||||.|..|:|.:||.:||..|.|..|::.||.||.|.:||.|.:||||||||||
Worm   694 QQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEKGINLSGGQKARVS 758

  Fly   561 LARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCL--NEFLSKKIRILVTHRVQLLRHVDHLVLLE 623
            ||||||:..|:|||||||||||:||.:.:.::.:  |..|.:|.||||||.:...:..|.::::.
Worm   759 LARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGLTYTKMADEILVML 823

  Fly   624 GGRISVQGHYDALKK--------LIRFR----------------------------------MSV 646
            .|:|...|.::.|.|        :..::                                  ::|
Worm   824 EGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEIQDYMNPEDVVLTV 888

  Fly   647 ANDVEVAKLRAMRTDSVYEEPEPRK----------SLSQEEHMDRHEIEQQFKEQQQIGSVKLQT 701
            .||::........|..:.....|.|          :.||.:.:.:..|.|        |.|::.|
Worm   889 TNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAATESQNKLIKKEGIAQ--------GKVEIAT 945

  Fly   702 YKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWA-TWEETEPNQHEPIPEYHRTRLRMMI 765
            |:.|.|..|: |:.:..:..|:|..:.:.....:||.|: .::...|:.| |:.:..|..:...:
Worm   946 YQLYVKAAGY-LLSIAFIGFFIVYMTLQILRSFWLSAWSDEYDPDSPSAH-PMAKGWRLGVYGAL 1008

  Fly   766 LYT-----FLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFS 825
            .::     |:.|..|:|          :..|.|..:|..|...::|:.|.|:.....||||||.:
Worm  1009 GFSETACFFVALLALVF----------VGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCA 1063

  Fly   826 SDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLL-IPATVVV----ALLYGCRCL----- 880
            .|:..||:.||      :.|....:.||.|..|..:.:: .|...||    ||:|    |
Worm  1064 KDIETIDMMLP------MNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIY----LIFLRY 1118

  Fly   881 YIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINR 945
            |:..||.|||:|::.|||||||...|.:|.|:|||........:|.....:......|..:..||
Worm  1119 YVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLVSNR 1183

  Fly   946 AFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYS--GDVGLAITQSMKLVLMCQAGMRQTVELEN 1006
            ..|...:.:  |:::..|:   |.:..|..|:.:  |.:|::::.::.:..:....:||..|:|.
Worm  1184 WLAVRLEFVGNCIIFFAAL---FAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQVSEIEA 1245

  Fly  1007 MMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGE 1071
            .:.|||||.||.|.|:|..:..|.....| .|||.|.:.|.....||......:|..::..:...
Worm  1246 NIVSVERVNEYTNTPNEAPWRIEGREPAP-GWPSRGVVKFDGYSTRYREGLDLVLHDISADVAAG 1309

  Fly  1072 EKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLR 1135
            |||||||.|.|||||...||||:.. ..|.|.||..|.||:||||||..|:|||||||||||:||
Worm  1310 EKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLFSGTLR 1374

  Fly  1136 FNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKI 1200
            ||||||...:|:::|.|||...||.|.:.|.||:..::.:.|.|.|:||||||.|||||||..::
Worm  1375 FNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALLRHTRV 1439

  Fly  1201 LIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELL 1265
            |::|||||.||..||.||||.|..:|..|||.||||||:|:||.||:||:|.|.::|...|..|:
Worm  1440 LVLDEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDTPDALM 1504

  Fly  1266 HNRHGYLHRFV 1276
            .:::....:.|
Worm  1505 ADKNSAFAKMV 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	429/1366 (31%)
		ABC_membrane	92..358	CDD:294371	59/272 (22%)
		ABCC_MRP_domain1	423..626	CDD:213217	94/204 (46%)
		ABC_membrane	762..988	CDD:294371	66/244 (27%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	117/219 (53%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	430/1376 (31%)
		ABC_membrane	310..575	CDD:294371	60/272 (22%)
		ABCC_MRP_domain1	622..826	CDD:213217	94/204 (46%)
		ABC_membrane	976..1227	CDD:279056	73/274 (27%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	117/219 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720