DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Abcc1

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_032602.1	Gene:	Abcc1 / 17250	MGIID:	102676	Length:	1528	Species:	Mus musculus

Alignment Length:	1392	Identity:	458/1392 - (32%)
Similarity:	704/1392 - (50%)	Gaps:	180/1392 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQEL 68
            ||: |.|.|.:.|:|.|:..|.|...::|.|.::.|:.|||:.......|.:|...|:.:|::|.
Mouse   202 VHD-RNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKEC 265

  Fly    69 KRSK------------------------------------------PNVLRMIFKAYGWSFVPAS 91
            .:|:                                          |::.::::|.:|..|: .|
Mouse   266 DKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFL-MS 329

  Fly    92 IVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRV 156
            .:|..:...:....|.:|..:::|.::.  :......|.|...:.:.:.:..|..|.:....|..
Mouse   330 FLYKALHDLMMFAGPKILELIINFVNDR--EAPDWQGYFYTALLFVSACLQTLALHQYFHICFVS 392

  Fly   157 GSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVY 221
            |.|::.|..|.||||.|.::.||..|...|..::||:.|...|.:.....:.:|..||:.::.:|
Mouse   393 GMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALY 457

  Fly   222 IIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWE 286
            .::..:|...:.|:..::..:||.|..|.....|:.:.....|.|:||||||:..::::|:||||
Mouse   458 FLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWE 522

  Fly   287 KSFAKLIGKVRKEEMDSIRGSTYIYA----GLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIV 347
            .:|...:..:|:||:..::.|.|:.|    ...||..:..||.|...|| |...:|:.::|.|:.
Mouse   523 LAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT-VDERNILDAKKAFVS 586

  Fly   348 ASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGV--HNFKEAEDNPEHGNFF 410
            .:.::.|... |:..|:.|:..|:..|...|::.|| .||......:  .:.|..|.|
Mouse   587 LALFNILRFP-LNILPMVISSIVQASVSLKRLRIFL-SHEELEPDSIERRSIKSGEGN------- 642

  Fly   411 GRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVIL 475
                       ||||...:.:|.:.:...    :..::|...:...|.:||.||.|||:||..:|
Mouse   643 -----------SITVKNATFTWARGEPPT----LNGITFSIPEGALVAVVGQVGCGKSSLLSALL 692

  Fly   476 GELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGD 540
            .|:|.:.|.|.:.|.::|.||:.|:...|||:||||..|..|..|..|:..|.|..|:|.||.||
Mouse   693 AEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGD 757

  Fly   541 STRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE--FLSKKIR 603
            .|.:||.|.:||||||.|||||||||..:||||.||||||||:||.|.:.::.:..  .|..|.|
Mouse   758 RTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTR 822

  Fly   604 ILVTHRVQLLRHVDHLVLLEGGRISVQGHYD-------ALKKLIRFRMSVANDVEVAKLRAMRTD 661
            |||||.:..|..||.::::.||:||..|.|.       |..:.:|...:...|:      |...|
Mouse   823 ILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDL------ASEDD 881

  Fly   662 SVYEEPEPRKSLSQ--------EEHMDRH---------EIEQQFK-------------------- 689
            ||....:..|.:..        .:|:.||         :..||..
Mouse   882 SVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEA 946

  Fly   690 EQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWA----TWEETEPNQH 750
            ::.|.|.|:|..|..|.|.:| ..:..|.:.:|:....|....:.:||.|.    ....|:.|::
Mouse   947 DKAQTGQVQLSVYWNYMKAIG-LFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRN 1010

  Fly   751 EPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMT----LRISLRIHDQLFQGVIRAFMHF 811
            ..:..|.    .:.||....|           ||:.|..    :..|.|:|..|...|:|:.|.|
Mouse  1011 FRLSVYG----ALGILQGAAI-----------FGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSF 1060

  Fly   812 FTLATSGRILNRFSSDVLAIDVNLPQAM---MDSIEFAVNALAVLAVVSTANIWLLIPATVVVAL 873
            |....||.::||||.::..:|..:||.:   |.|: |:|....::.:::|....::||...:|
Mouse  1061 FERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSL-FSVIGAVIIILLATPIAAVIIPPLGLV-- 1122

  Fly   874 LYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQ---NENTS 935
            .:..:..|:.:||.|||:|::||||:|||.|.|..|::.|||.   :..||..|...   :||..
Mouse  1123 YFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF---EEQERFIHQSDLKVDENQK 1184

  Fly   936 ALYLHVSINRAFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGM 998
            |.|..:..||..|...:.:  |::...|:   |.:..:| ...:|.|||:::.|:::.......:
Mouse  1185 AYYPSIVANRWLAVRLECVGNCIVLFAAL---FAVISRH-SLSAGLVGLSVSYSLQITAYLNWLV 1245

  Fly   999 RQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKG 1063
            |.:.|:|..:.:|||:.||.....|..::.:|:.. |..||..|:::|||..|||......:||.
Mouse  1246 RMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP-PSTWPHSGRVEFRDYCLRYREDLDLVLKH 1309

  Fly  1064 LTFTIRGEEKIGIVGHTAAGKSSIVHALFRL-AHINGHISIDGFETSQLGLHDLRRRISIIPQDP 1127
            :..||.|.||:||||.|.|||||:...|||: ....|.|.|||...:::|||:||.:|:||||||
Mouse  1310 INVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDP 1374

  Fly  1128 VLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDC---GANFSMGQRQLVC 1189
            ||||||||.|||||.:.:|||:|:|||...||.|||.|.|.:|   |:|   |.|.|:|||||||
Mouse  1375 VLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLN---HECAEGGENLSVGQRQLVC 1436

  Fly  1190 LARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGR 1254
            |||||||:.|||::|||||.||.|||||||..|.|:|..||||||||||:|:||..||:|:|.|.
Mouse  1437 LARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGE 1501

  Fly  1255 VVELGHPHELLHNRHGYLHRFVEKTGV 1281
            |.|.|.|.|||..| |..:...:..|:
Mouse  1502 VRECGAPSELLQQR-GIFYSMAKDAGL 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	452/1372 (33%)
		ABC_membrane	92..358	CDD:294371	69/269 (26%)
		ABCC_MRP_domain1	423..626	CDD:213217	90/204 (44%)
		ABC_membrane	762..988	CDD:294371	70/237 (30%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	132/222 (59%)
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	457/1390 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..895		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..929		4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650