DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and Cftr

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_066388.1	Gene:	Cftr / 12638	MGIID:	88388	Length:	1476	Species:	Mus musculus

Alignment Length:	1530	Identity:	388/1530 - (25%)
Similarity:	702/1530 - (45%)	Gaps:	288/1530 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLEST-QVSSFLLGHWEQE-LKRS 71
            |.:|:.||:|.||.||.||..||.||.:.:|:.||:|:. ||.:|. .:|..|...|::| ..:.
Mouse     2 QKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQA-PSADSADHLSEKLEREWDREQASKK 65

  Fly    72 KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTT---QPLMLGGLVSFFSESTGKITKHSAYLYAM 133
            .|.::..:.:.:.|.|    :.|.|:......|   ||::||.:::.: :...|:.:..|....:
Mouse    66 NPQLIHALRRCFFWRF----LFYGILLYLGEVTKAVQPVLLGRIIASY-DPENKVERSIAIYLGI 125

  Fly   134 GVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPT 198
            |:.|..::..|..||.:..|.|:|.::|.|...|:|:|.|::|....:....|..:||::.:|..
Mouse   126 GLCLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNK 190

  Fly   199 FNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVG 263
            |:|.....|.:|..||:..:.:.:::.|:.:.|..|||.::..:..||...:.:.:|:...|...
Mouse   191 FDEGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAILGKMMVKYRDQRAAKI 255

  Fly   264 DERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIR---------GSTYIYAGLQCTGM 319
            :||:.:.:|||..:..:|.|.||.:..|:|..:|:.|:...|         .|.:.::|.
Mouse   256 NERLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAAYMRFFTSSAFFFSGF----- 315

  Fly   320 ISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLF 384
               ..:|||::.|.....||. :|:|...|:...|..|:...:|.|:.:|.::|.:..:::|||.
Mouse   316 ---FVVFLSVLPYTVINGIVL-RKIFTTISFCIVLRMSVTRQFPTAVQIWYDSFGMIRKIQDFLQ 376

  Fly   385 QHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWD-----------QKKQE 438
            :.|         :|..|.|              .....|.:..::|.|:           |...:
Mouse   377 KQE---------YKVLEYN--------------LMTTGIIMENVTAFWEEGFGELLEKVQQSNGD 418

  Fly   439 KRHRH-----------------IEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVE 486
            ::|..                 :::::...:..:.:.|.|:.|:||::||.:|||||:...|.::
Mouse   419 RKHSSDENNVSFSHLCLVGNPVLKNINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIK 483

  Fly   487 VNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASL 551
            .:|.:|:..|..|::.|::::||:|...|||.||..|::.|.|.:|:.:....|:|.:||||.:|
Mouse   484 HSGRVSFCSQFSWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTL 548

  Fly   552 SGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHV 616
            ||||:||:|||||||:.||:||||.|...:|....:.:.:.|:.:.::.|.|||||.:::.||..
Mouse   549 SGGQRARISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSKMEHLRKA 613

  Fly   617 DHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDR 681
            |.:::|..|.....|.:..|:.|   |...::       :.|..|:..:..|.|:|....|.:.|
Mouse   614 DKILILHQGSSYFYGTFSELQSL---RPDFSS-------KLMGYDTFDQFTEERRSSILTETLRR 668

  Fly   682 HEIE----------QQFKEQQQIGSVKLQTYKEYFK-------VLGHPLVV-------------- 715
            ..::          |.|::..::|..:..:....|.       |...||.:
Mouse   669 FSVDDSSAPWSKPKQSFRQTGEVGEKRKNSILNSFSSVRKISIVQKTPLCIDGESDDLQEKRLSL 733

  Fly   716 ------------------------------VLILLMF--------------------VVARSSEA 730
                                          ||.|:.|                    :|.:.|..
Mouse   734 VPDSEQGEAALPRSNMIATGPTFPGRRRQSVLDLMTFTPNSGSSNLQRTRTSIRKISLVPQISLN 798

  Fly   731 TMDIF---LSKWATWEETEPNQHEPIPEYH-------------RTRLRMMILYTFLIL----CTL 775
            .:|::   ||:.:|...||....|.:.|..             .|.||...|:..|:|    |.|
Mouse   799 EVDVYSRRLSQDSTLNITEEINEEDLKECFLDDVIKIPPVTTWNTYLRYFTLHKGLLLVLIWCVL 863

  Fly   776 IFYVLRTFGFFMM--------------------------------------------TLRISL-- 794
            :|.|......|::                                            .|.:||
Mouse   864 VFLVEVAASLFVLWLLKNNPVNSGNNGTKISNSSYVVIITSTSFYYIFYIYVGVADTLLALSLFR 928

  Fly   795 -------------RIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFA 846
                         .:|.::...::.|.|...:...:|.||||||.|:..:|..||..:.|.|:..
Mouse   929 GLPLVHTLITASKILHRKMLHSILHAPMSTISKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLV 993

  Fly   847 VNALAVLAVVSTANIWLL---IPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFK 908
            ...:..:.|||....::.   :|..||..||   |..::..::.||::|:..||||::|...:.|
Mouse   994 FIVIGAIIVVSALQPYIFLATVPGLVVFILL---RAYFLHTAQQLKQLESEGRSPIFTHLVTSLK 1055

  Fly   909 GLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHR 973
            ||.|:||.....|.|..||...|.:|:..:::::..|.|....|:|.||:.:.|||..:|   ..
Mouse  1056 GLWTLRAFRRQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISIL---TT 1117

  Fly   974 GYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKH- 1037
            |...|..|:.:|.:|.::...|..:..:::.:::|.||.||.::::|.:|.:..|:....||:.
Mouse  1118 GEGEGTAGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESMYTQIIKELPREG 1182

  Fly  1038 -----------------WPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKS 1085
                             |||||::..:||.::|.:.|..:|:.::|:|...:::|::|.|.:|||
Mouse  1183 SSDVLVIKNEHVKKSDIWPSGGEMVVKDLTVKYMDDGNAVLENISFSISPGQRVGLLGRTGSGKS 1247

  Fly  1086 SIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELW 1150
            :::.|..|:.:|.|.|.|||...:.:.|.:.|:...:|.|...:|||:.|.||||..:..|||:|
Mouse  1248 TLLSAFLRMLNIKGDIEIDGVSWNSVTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWKDEEIW 1312

  Fly  1151 LALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETD 1215
            ...:.|.||..:......:|..|.|.|...|.|.:||:||||::|.:.||:::||.:|::||.|.
Mouse  1313 KVADEVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSAHLDPITY 1377

  Fly  1216 NLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTG 1280
            .:|:..:...||.|||:...||:..::|..|.:|::...|.:......||..:.      :.:..
Mouse  1378 QVIRRVLKQAFAGCTVILCEHRIEAMLDCQRFLVIEESNVWQYDSLQALLSEKS------IFQQA 1436

  Fly  1281 VGTAQHL-----RHLAEQSYRKRVLGRKSEDQGSV 1310
            :.:::.:     ||.::...|.::...|.|.:..|
Mouse  1437 ISSSEKMRFFQGRHSSKHKPRTQITALKEETEEEV 1471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	382/1481 (26%)
		ABC_membrane	92..358	CDD:294371	69/277 (25%)
		ABCC_MRP_domain1	423..626	CDD:213217	74/230 (32%)
		ABC_membrane	762..988	CDD:294371	71/291 (24%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	74/218 (34%)
Cftr	NP_066388.1	CFTR_protein	1..1464	CDD:273530	385/1521 (25%)
		ABC_membrane	85..303	CDD:294371	56/218 (26%)
		ABCC_CFTR1	389..670	CDD:213258	86/290 (30%)
		CFTR_R	639..844	CDD:291094	28/211 (13%)
		Disordered R region. /evidence=ECO:0000250\|UniProtKB:P13569	654..826		25/171 (15%)
		ABC_membrane	861..1142	CDD:279056	69/286 (24%)
		ABCC_CFTR2	1204..1464	CDD:213256	79/265 (30%)
		Interaction with GORASP2. /evidence=ECO:0000250\|UniProtKB:P13569	1382..1476		19/96 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1446..1476		6/26 (23%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P13569	1474..1476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841711
Domainoid	1	1.000	58	1.000	Domainoid score	I10724
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850