DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and ABCC2

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_000383.2	Gene:	ABCC2 / 1244	HGNCID:	53	Length:	1545	Species:	Homo sapiens

Alignment Length:	1395	Identity:	438/1395 - (31%)
Similarity:	713/1395 - (51%)	Gaps:	185/1395 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAVHEQRQP--NPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHW 64
            ||..|..:.  ||.:.|:|.|...:.|...|::||.:|.|...|::|.:..:::..:.|....|.
Human   182 SAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHM 246

  Fly    65 EQEL------------KRSKPN-----------------------------------------VL 76
            ::||            |.|:.|                                         ::
Human   247 KRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLM 311

  Fly    77 RMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLI 141
            :.:||.: :..:..|.:..::........|.:|..|:||.|:....:  ...||.|:.:...:||
Human   312 KALFKTF-YMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYL--WIGYLCAILLFTAALI 373

  Fly   142 SGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCF 206
            .......:.:..|::|.:||.|....||:|.|.:|..|......|..::||:.|.....:.....
Human   374 QSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFM 438

  Fly   207 HELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMN 271
            |.||...|:.|:.::.:::.:|...:.|:|.:|..||:.|..:......:..:....|:|:|:||
Human   439 HMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMN 503

  Fly   272 EIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGM-ISKLS-LFLSLVTY-- 332
            ||::.::::|.:|||.||...:..:||:|:.::    ..::.|||..: :.:|: :.:|:||:
Human   504 EILSGIKILKYFAWEPSFRDQVQNLRKKELKNL----LAFSQLQCVVIFVFQLTPVLVSVVTFSV 564

  Fly   333 ---VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGV 394
               |.:.:|:.:||.|...:.::.|... |...|:.|:..::..|...|::.:|...:.......
Human   565 YVLVDSNNILDAQKAFTSITLFNILRFP-LSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIR 628

  Fly   395 H--NFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFV 457
            |  ||.                      |::...:.|.:|:...:..    :.||:......|.|
Human   629 HDCNFD----------------------KAMQFSEASFTWEHDSEAT----VRDVNLDIMAGQLV 667

  Fly   458 GIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLE 522
            .::|.||:|||:|:..:|||::.:.|.:.:.|..:|.||:.|:..|:::|||||...::|:||.:
Human   668 AVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQ 732

  Fly   523 VLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSK 587
            ||..|.|..|:|.||.||...:||.|.:||||||.|:|||||.|:..|||||||||||||:||.|
Human   733 VLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGK 797

  Fly   588 MLLDRCL--NEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDA-----------LKKL 639
            .:.::.|  |..|..|.|:||||.:..|..||.:|:|..|.|..:|.|.|           ||..
Human   798 HIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTF 862

  Fly   640 IRFR----------------------MSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMD-- 680
            :|..                      .||....|.|....||.::.:.....|.|.|...|:.
Human   863 LRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSL 927

  Fly   681 RHEIE----QQFKEQQQI--------------GSVKLQTYKEYFKVLGHPLVVVLILLMFVVARS 727
            |:.::    ...||.:::              |.||...|.||.:.:| ...:..|:|.||:...
Human   928 RNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIG-LFSIFFIILAFVMNSV 991

  Fly   728 SEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMI-LYTFLILCTLIFYVL----RTFGFFM 787
            :....:::||.|     |..::.....:|..::..|.: :|..|.|...||..:    ..|||
Human   992 AFIGSNLWLSAW-----TSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGF-- 1049

  Fly   788 MTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAV 852
              :..|..:|.||...::||.|.||....:|||:|||:.|:..:|..|||::...|...:..::.
Human  1050 --VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIIST 1112

  Fly   853 LAVVSTAN-IWLLIPATVVVALLY-GCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRA 915
            |.::..|. ::.:|  .:.:.::| ..:..|:..||.|:|:::::|||||||.:.|..||..|||
Human  1113 LVMICMATPVFTII--VIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRA 1175

  Fly   916 LNGTKYMERDFHYYQ---NENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYS 977
            .   ::.:|...:.:   :.|...::..::.||..|...:|:   ..|.|.||.|:...:|...|
Human  1176 F---EHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELV---GNLTVFFSALMMVIYRDTLS 1234

  Fly   978 GD-VGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSG 1041
            || ||..::.::.:.......:|.|.|:|..:.:|||:.||..:.:|..:.|::  ..|..|||.
Human  1235 GDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDK--RPPPDWPSK 1297

  Fly  1042 GQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFR-LAHINGHISIDG 1105
            |::.|.:.::||......:|:|:|..|...||||:||.|.|||||:.:.||| |....|.|.|||
Human  1298 GKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDG 1362

  Fly  1106 FETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGIN 1170
            .:.:.:||||||.:::||||||:|||||||.|||||...:|||:|.|||...||.||::|:.|::
Human  1363 VDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLS 1427

  Fly  1171 CRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIA 1235
            ..:.:.|.|.|:|||||:||.|||||::|||::|||||.||.|||||||..|..:||||||:|||
Human  1428 HEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIA 1492

  Fly  1236 HRLHTVMDNDRVMVVDMGRVVELGHPHELL 1265
            |||||:||:|:|||:|.|:::|.|.|.|||
Human  1493 HRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	435/1388 (31%)
		ABC_membrane	92..358	CDD:294371	67/272 (25%)
		ABCC_MRP_domain1	423..626	CDD:213217	87/204 (43%)
		ABC_membrane	762..988	CDD:294371	69/236 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	123/219 (56%)
ABCC2	NP_000383.2	SunT	8..1537	CDD:331423	438/1395 (31%)
ABCC2	NP_000383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..284		3/30 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750