Protein Alignment CG11898 and CFTR

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Alignment Length: 1521
• Identity: 394/1521 - (25%)
• Similarity: 705/1521 - (46%)
• Gaps: 262/1521 - (17%)

  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLEST-QVSSFLLGHWEQELKRSK 72
            |.:|:.||:..||.||.|||.||.||.::.|:.||:|:. ||::|. .:|..|...|::||...|
Human     2 QRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQI-PSVDSADNLSEKLEREWDRELASKK 65

  Fly    73 -PNVLRMIFKAYGWSFVPASIVYSIMAIAVHTT---QPLMLGGLVSFFSESTGKITKHSAYLYAM 133
             |.::..:.:.:.|.|    :.|.|.......|   |||:||.:::.:.....:....:.|| .:
Human    66 NPKLINALRRCFFWRF----MFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYL-GI 125

  Fly   134 GVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPT 198
            |:.|..::..|..||.:..|..:|.::|:|...|:|:|.|::|....:....|..:||::.:|..
Human   126 GLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNK 190

  Fly   199 FNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVG 263
            |:|.....|.:|..||:..:.:.:|::|:...|..|||.::.....||...|.:.:|:...|...
Human   191 FDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKI 255

  Fly   264 DERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYI-YAGLQCTGMISKLSLFL 327
            .||:.:.:|:|..:|.:|.|.||::..|:|..:|:.|:...|.:.|: |.............:||
Human   256 SERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFL 320

  Fly   328 SLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADG 392
            |::.|.....|:. :|:|...|:...|..::...:|.|:..|.::....|:::|||.:.|
Human   321 SVLPYALIKGIIL-RKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQE----- 379

  Fly   393 GVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQ--------KKQEKRHRH------ 443
                :|..|.|              .....:.:..::|.|::        .||...:|.
Human   380 ----YKTLEYN--------------LTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDD 426

  Fly   444 --------------IEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYA 494
                          ::|::|:.:..|.:.:.|:.||||::||.||:|||:...|.::.:|.:|:.
Human   427 SLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFC 491

  Fly   495 PQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARV 559
            .|..|::.|::::||:|...|||.||..|::.|.|:.|:.:....|:..:||||.:|||||:||:
Human   492 SQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARI 556

  Fly   560 SLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEG 624
            |||||||:.||:||||.|...:|....|.:.:.|:.:.::.|.|||||.:::.|:..|.:::|..
Human   557 SLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHE 621

  Fly   625 G---------------------------------------------RISVQGH------------ 632
            |                                             |.|::|.
Human   622 GSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQS 686

  Fly   633 ------------------YDALKKL--------------------IRFRMSVANDVEVAK----- 654
                              .::::|.                    :..|:|:..|.|..:
Human   687 FKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPR 751

  Fly   655 ---------LRAMRTDSVYE-------------------------EPEPR--------KSLSQEE 677
                     |:|.|..||..                         .|:..        :.||||.
Human   752 ISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQET 816

  Fly   678 HMD-RHEIEQQ------FKEQQQIGSVKL-QTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDI 734
            .:: ..||.::      |.:.:.|.:|.. .||..|..|  |..::.:::...|:..:..|...:
Human   817 GLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITV--HKSLIFVLIWCLVIFLAEVAASLV 879

  Fly   735 FLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYV----------LRTFGFFM-- 787
            .|  |..  ...|.|.:....:.|..     .|..:|..|..:||          |...|||.
Human   880 VL--WLL--GNTPLQDKGNSTHSRNN-----SYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGL 935

  Fly   788 ----MTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVN 848
                ..:.:|..:|.::...|::|.|.......:|.||||||.|:..:|..||..:.|.|:..:.
Human   936 PLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLI 1000

  Fly   849 ALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATI 913
            .:..:|||:....::.:....|:......|..::..|:.||::|:..||||::|...:.|||.|:
Human  1001 VIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTL 1065

  Fly   914 RALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSG 978
            ||.....|.|..||...|.:|:..:|::|..|.|....::|.|::.:||||..:|   ..|...|
Human  1066 RAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISIL---TTGEGEG 1127

  Fly   979 DVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSE--PAYETE------------ 1029
            .||:.:|.:|.::...|..:..:::::::|.||.||.:::::|:|  |...|:
Human  1128 RVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMI 1192

  Fly  1030 -ESVNLPKH--WPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHAL 1091
             |:.::.|.  ||||||:..:||..:|:..|..||:.::|:|...:::|::|.|.:|||:::.|.
Human  1193 IENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAF 1257

  Fly  1092 FRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAV 1156
            .||.:..|.|.|||.....:.|...|:...:|||...:|||:.|.||||:|:.:|:|:|...:.|
Human  1258 LRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEV 1322

  Fly  1157 KLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEA 1221
            .|:..:......::..|.|.|...|.|.:||:||||::|.:.|||::||.:|::||.|..:|:..
Human  1323 GLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387

  Fly  1222 IHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGVGTAQH 1286
            :...||.|||:...||:..:::..:.:|::..:|.:.....:||:.|..:.........|....|
Human  1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH 1452

  Fly  1287 LRHLAEQSYRKRVLGRKSEDQGSVLD 1312
             |:.::...:.::...|.|.:..|.|
Human  1453 -RNSSKCKSKPQIAALKEETEEEVQD 1477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	386/1475 (26%)
		ABC_membrane	92..358	CDD:294371	70/269 (26%)
		ABCC_MRP_domain1	423..626	CDD:213217	77/275 (28%)
		ABC_membrane	762..988	CDD:294371	69/241 (29%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	74/218 (34%)
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	394/1521 (26%)
		ABC_membrane	85..303	CDD:279056	59/218 (27%)
		ABCC_CFTR1	389..670	CDD:213258	78/280 (28%)
		CFTR_R	639..849	CDD:291094	23/209 (11%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		20/176 (11%)
		ABC_membrane	866..1147	CDD:279056	78/292 (27%)
		ABCC_CFTR2	1208..1480	CDD:213256	84/271 (31%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		19/93 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480		6/27 (22%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480		394/1521 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151593
Domainoid	1	1.000	62	1.000	Domainoid score	I10331
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850