Protein Alignment CG11898 and ABCC4

DIOPT Version :10

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_005836.2
• Gene: ABCC4 / 10257
• HGNCID: 55
• Length: 1325
• Species: Homo sapiens
• Alignment Length: 1344
• Identity: 478/1344 - (35%)
• Similarity: 767/1344 - (57%)
• Gaps: 95/1344 - (7%)

  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65
            |..|:::.:|||:..||..|:.||.|...:...|.:|.|:..|:|...|...|..:...|.|.|:
Human     1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWD 65

  Fly    66 QELKRS-----KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFS--ESTGKI 123
            :|:.|:     ||::.|.|.|.|..|::...| ::::..:....||:.||.::::|.  :....:
Human    66 KEVLRAENDAQKPSLTRAIIKCYWKSYLVLGI-FTLIEESAKVIQPIFLGKIINYFENYDPMDSV 129

  Fly   124 TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYA 188
            ..::||.||..:..|:||..:..|.:..::...|.|:|:|...::|||.||:|..|.....:|..
Human   130 ALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQI 194

  Fly   189 ISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIA 253
            ::|::.|:..|::.....|.||.|||:.:....:::..||...:.|:..::..:|||:...:..:
Human   195 VNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFS 259

  Fly   254 RYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTG 318
            ..:..:|...|.|::.|||:|..:::||||||||||:.||..:||:|:..|..|:.: .|:....
Human   260 SLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCL-RGMNLAS 323

  Fly   319 MI--SKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKD 381
            ..  ||:.:|::..|||..|.::|:.:||:..:.|..:..::...:|.||....|..|...|::.
Human   324 FFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQT 388

  Fly   382 FLF-------QHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEK 439
            ||.       ..:.|:||                           .|.:.|...:|.||:..:..
Human   389 FLLLDEISQRNRQLPSDG---------------------------KKMVHVQDFTAFWDKASETP 426

  Fly   440 RHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGS 504
            .   ::.:||..:..:.:.:||.||||||:||..:||||....|.|.|:|.::|..|:||:..|:
Human   427 T---LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGT 488

  Fly   505 LRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKA 569
            ||.||||.:.|:::||.:|::.|.|.:|::.|..||.|.:|:.|.:|||||||||:||||||:.|
Human   489 LRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDA 553

  Fly   570 DIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHY- 633
            |||||||||||||:.||:.|.:.|:.:.|.:||.|||||::|.|:....:::|:.|::..:|.|
Human   554 DIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYT 618

  Fly   634 DALKKLIRFRMSVANDVE-----------VAKLRAMRTDSVYEEPEPRKSLSQE--EHMDRHEIE 685
            :.||..|.|...:..|.|           ..:.|.....||:.:...|.||...  |..|...:.
Human   619 EFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVP 683

  Fly   686 QQFKEQQQI-GSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWA--------- 740
            ....|:.:. |.|..|.||.||:...|.:|.:.::|:...|:.:....|.:||.||
Human   684 VTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVT 748

  Fly   741 ------TWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQ 799
                  ..|:.:.|.:             :.:|:.|.:.|::|.:.|:...|.:.:..|..:|::
Human   749 VNGGGNVTEKLDLNWY-------------LGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNK 800

  Fly   800 LFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLL 864
            :|:.:::|.:.||.....||||||||.|:..:|..||...:|.|:..:..:.|::|......|:.
Human   801 MFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIA 865

  Fly   865 IPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYY 929
            ||...:..:....|..::..||.:||:|:.:|||::||.:::.:||.||||....:..:..|..:
Human   866 IPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAH 930

  Fly   930 QNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMC 994
            |:.::.|.:|.::.:|.||...|.||.::::.|.|..|:..|...  :|.||||::.::.|:.|.
Human   931 QDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLD--AGQVGLALSYALTLMGMF 993

  Fly   995 QAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPY 1059
            |..:||:.|:||||.|||||:||.::..|..:|.::  ..|..||..|.:.|.::...||..||.
Human   994 QWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQK--RPPPAWPHEGVIIFDNVNFMYSPGGPL 1056

  Fly  1060 ILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIP 1124
            :||.||..|:.:||:||||.|.|||||::.|||||:...|.|.||...|:::||||||:::||||
Human  1057 VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIP 1121

  Fly  1125 QDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVC 1189
            |:||||:|::|.|||||.|.||||||.||:.|:|||.:.:|...::..|.:.|:|||:|||||||
Human  1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVC 1186

  Fly  1190 LARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGR 1254
            ||||:||:|:|||:|||||||||.||.|||:.|..||||||||||||||:|::|:|::||:|.||
Human  1187 LARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGR 1251

  Fly  1255 VVELGHPHELLHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKR 1298
            :.|...|:.||.|:....::.|::.|...|..|...|:|.|.||
Human  1252 LKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKR 1295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	467/1311 (36%)
ABCC4	NP_005836.2	PLN03130	12..1277	CDD:215595	466/1313 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..688		7/30 (23%)
		PDZ-binding	1322..1325