DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11898 and ABCC4

DIOPT Version :9

Sequence 1:NP_651679.2 Gene:CG11898 / 43451 FlyBaseID:FBgn0039645 Length:1320 Species:Drosophila melanogaster
Sequence 2:NP_005836.2 Gene:ABCC4 / 10257 HGNCID:55 Length:1325 Species:Homo sapiens


Alignment Length:1344 Identity:478/1344 - (35%)
Similarity:767/1344 - (57%) Gaps:95/1344 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65
            |..|:::.:|||:..||..|:.||.|...:...|.:|.|:..|:|...|...|..:...|.|.|:
Human     1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWD 65

  Fly    66 QELKRS-----KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFS--ESTGKI 123
            :|:.|:     ||::.|.|.|.|..|::...| ::::..:....||:.||.::::|.  :....:
Human    66 KEVLRAENDAQKPSLTRAIIKCYWKSYLVLGI-FTLIEESAKVIQPIFLGKIINYFENYDPMDSV 129

  Fly   124 TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYA 188
            ..::||.||..:..|:||..:..|.:..::...|.|:|:|...::|||.||:|..|.....:|..
Human   130 ALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQI 194

  Fly   189 ISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIA 253
            ::|::.|:..|::.....|.||.|||:.:....:::..||...:.|:..::..:|||:...:..:
Human   195 VNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFS 259

  Fly   254 RYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTG 318
            ..:..:|...|.|::.|||:|..:::||||||||||:.||..:||:|:..|..|:.: .|:....
Human   260 SLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCL-RGMNLAS 323

  Fly   319 MI--SKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKD 381
            ..  ||:.:|::..|||..|.::|:.:||:..:.|..:..::...:|.||....|..|...|::.
Human   324 FFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQT 388

  Fly   382 FLF-------QHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEK 439
            ||.       ..:.|:||                           .|.:.|...:|.||:..:..
Human   389 FLLLDEISQRNRQLPSDG---------------------------KKMVHVQDFTAFWDKASETP 426

  Fly   440 RHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGS 504
            .   ::.:||..:..:.:.:||.||||||:||..:||||....|.|.|:|.::|..|:||:..|:
Human   427 T---LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGT 488

  Fly   505 LRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKA 569
            ||.||||.:.|:::||.:|::.|.|.:|::.|..||.|.:|:.|.:|||||||||:||||||:.|
Human   489 LRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDA 553

  Fly   570 DIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHY- 633
            |||||||||||||:.||:.|.:.|:.:.|.:||.|||||::|.|:....:::|:.|::..:|.| 
Human   554 DIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYT 618

  Fly   634 DALKKLIRFRMSVANDVE-----------VAKLRAMRTDSVYEEPEPRKSLSQE--EHMDRHEIE 685
            :.||..|.|...:..|.|           ..:.|.....||:.:...|.||...  |..|...:.
Human   619 EFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVP 683

  Fly   686 QQFKEQQQI-GSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWA--------- 740
            ....|:.:. |.|..|.||.||:...|.:|.:.::|:...|:.:....|.:||.||         
Human   684 VTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVT 748

  Fly   741 ------TWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQ 799
                  ..|:.:.|.:             :.:|:.|.:.|::|.:.|:...|.:.:..|..:|::
Human   749 VNGGGNVTEKLDLNWY-------------LGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNK 800

  Fly   800 LFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLL 864
            :|:.:::|.:.||.....||||||||.|:..:|..||...:|.|:..:..:.|::|......|:.
Human   801 MFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIA 865

  Fly   865 IPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYY 929
            ||...:..:....|..::..||.:||:|:.:|||::||.:::.:||.||||....:..:..|..:
Human   866 IPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAH 930

  Fly   930 QNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMC 994
            |:.::.|.:|.::.:|.||...|.||.::::.|.|..|:..|...  :|.||||::.::.|:.|.
Human   931 QDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLD--AGQVGLALSYALTLMGMF 993

  Fly   995 QAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPY 1059
            |..:||:.|:||||.|||||:||.::..|..:|.::  ..|..||..|.:.|.::...||..||.
Human   994 QWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQK--RPPPAWPHEGVIIFDNVNFMYSPGGPL 1056

  Fly  1060 ILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIP 1124
            :||.||..|:.:||:||||.|.|||||::.|||||:...|.|.||...|:::||||||:::||||
Human  1057 VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIP 1121

  Fly  1125 QDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVC 1189
            |:||||:|::|.|||||.|.||||||.||:.|:|||.:.:|...::..|.:.|:|||:|||||||
Human  1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVC 1186

  Fly  1190 LARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGR 1254
            ||||:||:|:|||:|||||||||.||.|||:.|..||||||||||||||:|::|:|::||:|.||
Human  1187 LARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGR 1251

  Fly  1255 VVELGHPHELLHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKR 1298
            :.|...|:.||.|:....::.|::.|...|..|...|:|.|.||
Human  1252 LKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKR 1295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11898NP_651679.2 CFTR_protein 9..1268 CDD:273530 466/1304 (36%)
ABC_membrane 92..358 CDD:294371 77/269 (29%)
ABCC_MRP_domain1 423..626 CDD:213217 92/202 (46%)
ABC_membrane 762..988 CDD:294371 67/225 (30%)
ABCC_MRP_domain2 1042..1261 CDD:213211 129/218 (59%)
ABCC4NP_005836.2 CFTR_protein 11..1269 CDD:273530 466/1306 (36%)
ABC_membrane 96..365 CDD:294371 77/270 (29%)
ABCC_MRP_domain1 410..610 CDD:213217 92/202 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 657..688 7/30 (23%)
ABC_membrane 718..991 CDD:279056 77/287 (27%)
ABCC_MRP_domain2 1039..1258 CDD:213211 129/218 (59%)
PDZ-binding 1322..1325
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151550
Domainoid 1 1.000 101 1.000 Domainoid score I6950
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.850

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