DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcc8

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_031756190.1	Gene:	abcc8 / 101730668	-ID:	-	Length:	1580	Species:	Xenopus tropicalis

Alignment Length:	1427	Identity:	389/1427 - (27%)
Similarity:	663/1427 - (46%)	Gaps:	238/1427 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGH--WEQELKRSKP------ 73
            |..||..:.|....:....::.:|...:.:...::.:  |:::||.:  :..:..:|.|
Frog   223 NLLSKGTYWWMNTFIKTAHKKPIDLKAIGKLPIAMRA--VTNYLLLNKAFHSQKSKSSPCPAGPK 285

  Fly    74 NVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKH------------ 126
            ::...:.:|:|...:.:|| :.|||..:....||.:.|:|...|:...  |.|
Frog   286 SIWFALCQAFGRPLILSSI-FRIMADMLGFAGPLCISGIVHHLSQENK--TFHPQPIFLGVFFIS 347

  Fly   127 ------SAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSG-- 183
                  :||:.|:.:....|:...|...........|..:|.|....:|.|.:.:|.:..:.|
Frog   348 SQEFLANAYVLAVLLFFALLLQRSFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNMSMGEM 412

  Fly   184 VSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWA 248
            .||...:|:|.|.......|:....||..|::.:|.|.::|.::|..|::|...|:...|:|.:.
Frog   413 SSGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGISALIGAVVIIVLAPIQYFV 477

  Fly   249 ARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAG 313
            |..:::.:||:.:..:||:|..||::..::|:|:|:||..|...:.:.|::||:|
Frog   478 ATKLSQAQRSTLEYSNERLKKTNEMLRGIKLLKLYSWEHIFHSSVEETRQKEMNS---------- 532

  Fly   314 LQCTGMISKLSLFLS--------LVTYVFTGDIVTSQKVFIVASYYDHLNDSLLH--SWPL---- 364
            |:...:.:.:|:|::        |:|:|....::..:: |..|..:..|  ||.|  ..||
Frog   533 LKAFALYTSISIFMNAAIPIAAVLITFVVHVHLLHREQ-FSPAVAFASL--SLFHILVTPLFLLS 594

  Fly   365 -AINMWVETFVVANRVKDFLFQHE--------NPADGGV-----------------------HNF 397
             .:...|:..|...::.:|....|        .|::..|                       ::|
Frog   595 SVVRSTVKALVSVQKLSEFFSSEEIGEEVEKCPPSNKSVPQNKYQAVPLKVVNRKRPIRDDWNHF 659

  Fly   398 KEAE---DNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGI 459
            ...:   .||..||.|           .|.|.....:|.......    :..:..:....|...|
Frog   660 NSRQRGAPNPTEGNEF-----------CIKVTSGFFTWTPDGPPA----LSSIDIRIPQGQLTMI 709

  Fly   460 VGTVGAGKSTLLQVILGELDIISGSVEVN---------------------------GVLSYAPQE 497
            ||.||.|||:||...|||:..|||.|..|                           |.::||.|:
Frog   710 VGQVGCGKSSLLLATLGEMHKISGDVSWNSTVPDSETGEDVNPDKETAIDVETRRRGAVAYASQK 774

  Fly   498 PWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLA 562
            ||||..::.:||.|..|:::|:|..::..|.|..|::.||.||.|::||.|.:|||||:.|:|:|
Frog   775 PWLLNATVEENITFESPFNKQKYKAIIDACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVA 839

  Fly   563 RAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFL--SKKIRILVTHRVQLLRHVDHLVLLEGG 625
            |.:|::..:..||||.||:|.|:|..|:...:.:.|  :|:..:||||::|.|.|.|.::.::.|
Frog   840 RVLYQQTSVVFLDDPFSALDIHLSDHLMHEGILKMLRDNKRTTVLVTHKLQYLPHADWIIAMKDG 904

  Fly   626 RISVQGH-----------YDALKKLI-----RFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLS 674
            .|..:|.           |:..|.|:     .....:..|.:....|...|.::|    ||.:|.
Frog   905 TIQREGTLKDIQKSDPELYEHWKTLMNRQDQELEKEIILDRKAGGERMNLTRTIY----PRDALL 965

  Fly   675 QEEHMDRHEIEQQFKEQQQIGSVKLQTYKEYFKVLGH------PLVVVLILLMFVVARSSEATMD 733
            .::..|..||.:..::...:.||..|..|..::..|.      .|::.|::|..::..|....:|
Frog   966 GDDEEDEEEISESEEDDDNLSSVLHQRAKMPWRACGKYLSSAGILLLPLLVLSQLLKHSVMVAID 1030

  Fly   734 IFLSKWATWEETEPN------------QHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFF 786
            .:|:||.:...|..:            .|.|.                    ::.|.:|...|..
Frog  1031 FWLAKWTSAAITNLSVANCSGRPTCRFDHSPY--------------------SMAFSILSCVGII 1075

  Fly   787 MMT----------LRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLP---QA 838
            |..          ||::.::|..|...:|.|.|.||.....|.||||||:|...||.::|   :.
Frog  1076 MCLATSIAVEWTGLRVAKKLHSSLLNAIILAPMRFFETTPLGSILNRFSADFNTIDQHIPATLEC 1140

  Fly   839 MMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIG-----ASRSLKRIETISRSP 898
            :..|....|:||||::.|:...:..|:|..::        |.:|.     |||.|:::|..::.|
Frog  1141 LSRSTLLCVSALAVISYVTPVFLISLVPLAII--------CYFIQKYFRVASRDLQQLEDSTQLP 1197

  Fly   899 IYSHTNATFKGLATIRALN-GTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDL------ICV 956
            :.||...|.:||.||||.. ..::.::...:..:.|.::|:| .:.||    |.::      .||
Frog  1198 LLSHFAETVEGLTTIRAFRYEPRFRQKLLEHTDSNNIASLFL-TAANR----WLEVRMEYIGACV 1257

  Fly   957 LYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIP 1021
            :.|.||  :.:....|....||.|||.:|.::.:.......:|...::|..:.:|:|:...:...
Frog  1258 VLIAAV--ASITNSLHYNLSSGLVGLGLTYALMVSNYLNWMVRNLSDMEIQLGAVKRINGLLKTE 1320

  Fly  1022 SEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSS 1086
            .|..........:|.:||..|::..::|.:||.:....:||.:...|...:||||.|.|.:||||
Frog  1321 PENYKGLLSPTQIPPNWPENGEIQIQNLSVRYDSSLKPVLKHVNAHITPGQKIGICGRTGSGKSS 1385

  Fly  1087 IVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELW 1150
            ...|.||:.. ..|.|.|||.:.::|.|..||.|:|||.|||:||||::||||||..:.||..||
Frog  1386 FSLAFFRMVDTFQGRIIIDGIDIAKLPLQTLRSRLSIILQDPILFSGTIRFNLDPENKCTDAMLW 1450

  Fly  1151 LALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETD 1215
            .|||..:||..|..|..|::..:.:.|.|||:|||||.|||||.:|::.|||||||||::|..|:
Frog  1451 EALEIAQLKHVVKVLPGGLDALVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1515

  Fly  1216 NLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVE 1277
            |::|:.:.|.|...||:|||||:||:::.|.|:|:..|.::|...|..||.........:|:
Frog  1516 NILQKVVMTAFDDRTVVTIAHRVHTILNADLVIVMKRGAIMEYDKPEALLEGGGSMFASYVQ 1577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	388/1416 (27%)
		ABC_membrane	92..358	CDD:294371	68/293 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	77/231 (33%)
		ABC_membrane	762..988	CDD:294371	68/250 (27%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	102/219 (47%)
abcc8	XP_031756190.1	MRP_assoc_pro	224..1573	CDD:188098	387/1420 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010