Protein Alignment CG11898 and ABCC9

DIOPT Version :10

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_005682.2
• Gene: ABCC9 / 10060
• HGNCID: 60
• Length: 1549
• Species: Homo sapiens
• Alignment Length: 1366
• Identity: 392/1366 - (28%)
• Similarity: 669/1366 - (48%)
• Gaps: 147/1366 - (10%)

  Fly    17 NFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELKR------SKPNV 75
            |..||..:.|...:::...::.:|...:.:...::.:......|...:|::.|:      ..|::
Human   221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSI 285

  Fly    76 LRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSE-------STG-------KITKH 126
            ...:::|:|...:.:| .:..:|..:....||.:.|:|...:|       :||       |....
Human   286 WLAMYRAFGRPILLSS-TFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLE 349

  Fly   127 SAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSG--VSGYAI 189
            :||:.|:.:.|..::...|...........|..:|.|...::|.|.||:|.:..:.|  ..|...
Human   350 NAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQIN 414

  Fly   190 SLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIAR 254
            :|:|.:........:....||..|::.::.|.::|.|:|..|:||...||...|:|.:.|..:|.
Human   415 NLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAE 479

  Fly   255 YKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGM 319
            .::|:.|...||:|..|||:..::|:|:||||..|.|.:.:.|.:|:.|::  |:        .:
Human   480 AQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLK--TF--------AL 534

  Fly   320 ISKLSLFLS--------LVTYV----FTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVET 372
            .:.||:|::        |.|:|    .:|:.:...:.|...|.: |:..:.|......:...|:.
Human   535 YTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLF-HILVTPLFLLSTVVRFAVKA 598

  Fly   373 FVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSA------S 431
            .:...::.:||...|.    |..:::..|.:...     .:.|....|:..|:::...      |
Human   599 IISVQKLNEFLLSDEI----GDDSWRTGESSLPF-----ESCKKHTGVQPKTINRKQPGRYHLDS 654

  Fly   432 WDQKKQEKRHRHIEDVSFQAQD---------------------QQFVGIVGTVGAGKSTLLQVIL 475
            ::|..:..|....||::.:..:                     .|...|||.||.|||:||..||
Human   655 YEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAIL 719

  Fly   476 GELDIISGSVEVNGV-----------------LSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEV 523
            ||:..:.|.|..:.|                 ::||.|:||||..::.:||.|..|:::|||..|
Human   720 GEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784

  Fly   524 LRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKM 588
            ...|.|..|::.||.||.|.:||.|.:|||||:.|:.:|||:|:..:|..||||.||:|.|:|..
Human   785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDH 849

  Fly   589 LLDRCLNEFL--SKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGH-----------YDALKKLI 640
            |:...:.:||  .|:..:||||::|.|.|.|.::.::.|.:..:|.           |:..|.|:
Human   850 LMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLM 914

  Fly   641 -RFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQQIGSVKLQT--- 701
             |....:..|:| |....:...::......|::.:|.|..|..|.|::.::......::|:|
Human   915 NRQDQELEKDME-ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMP 978

  Fly   702 YKEYFKVLGHPLVVVLILLMF--VVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMM 764
            :|..::.|......:|||::|  ::..|....:|.:|:.| |.|.:..|..:....|:
Human   979 WKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW-TSEYSINNTGKADQTYY------- 1035

  Fly   765 ILYTFLILCTL-IFYVLRT-FGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSD 827
             :..|.|||.. ||..|.| .....|.|..:..:|..|...:|...:.||.....|.||||||:|
Human  1036 -VAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099

  Fly   828 VLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIG-----ASRS 887
            ...||.::|..:.......:..|:.:.::|.|.     |..:|..|..|....:|.     ||:.
Human  1100 TNIIDQHIPPTLESLTRSTLLCLSAIGMISYAT-----PVFLVALLPLGVAFYFIQKYFRVASKD 1159

  Fly   888 LKRIETISRSPIYSHTNATFKGLATIRAL-NGTKYMERDFHYYQNENTSALYLHVSINRAFAFWT 951
            |:.::..::.|:..|.:.|.:||.||||. :.|::.:|........|.:.|:|..: ||.....|
Human  1160 LQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAA-NRWLEVRT 1223

  Fly   952 DLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVME 1016
            |.:....:|..:.:.:....:    ||.|||.:..::.:.......:|...:||..|.:|::|..
Human  1224 DYLGACIVLTASIASISGSSN----SGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNS 1284

  Fly  1017 YVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTA 1081
            ::.:.||....|.:...:|:|||..|::...||.:||.|:...:||.:...|:..:|:||.|.|.
Human  1285 FLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1349

  Fly  1082 AGKSSIVHALFRLAHI-NGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKT 1145
            :||||:..|.||:..| :|.|.|||.:.|:|.||.||.|:|||.|||:|||||:||||||..:.|
Human  1350 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCT 1414

  Fly  1146 DEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANV 1210
            |:.||.|||..:||..|.:|..|::..:.:.|.|||:|||||.|||||.:|::.|||||||||::
Human  1415 DDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASI 1479

  Fly  1211 DPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRF 1275
            |..|:|::|:.:.|.||..||:|||||:.::||...|:|...|.:||......||.:::|.....
Human  1480 DMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1544

  Fly  1276 V 1276
            |
Human  1545 V 1545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	390/1356 (29%)
ABCC9	NP_005682.2	MRP_assoc_pro	222..1541	CDD:188098	390/1359 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	944..967		6/22 (27%)