Protein Alignment CG11898 and ABCC5

DIOPT Version :10

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Alignment Length: 1376
• Identity: 431/1376 - (31%)
• Similarity: 688/1376 - (50%)
• Gaps: 170/1376 - (12%)

  Fly     8 RQPNPVTKANFFSKWFFIWTREIL-VKGLQRNLDPSDLYETEPSLESTQVSSFLLGH-WEQELKR 70
            :..:||..|..||...|.|...:. |...:..|...|::..... ||:.|:...|.. |::||..
Human    96 KHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKH-ESSDVNCRRLERLWQEELNE 159

  Fly    71 SKPNV--LRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGG---LVSFFSESTGKITKHSAY- 129
            ..|:.  ||.:.    |.|....::.||:.:.:  ||.....|   :|....|.|.....:..|
Human   160 VGPDAASLRRVV----WIFCRTRLILSIVCLMI--TQLAGFSGPAFMVKHLLEYTQATESNLQYS 218

  Fly   130 -LYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMA 193
             |..:|::|..::............:|.|.|:|.|...:.::|.|::....:.|  .|..|::.:
Human   219 LLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICS 281

  Fly   194 TDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLI--GWPAVVGLGTIVAFIPLQAWAARAIARYK 256
            .|.....|:......|..||:  |..:.:||.:|  |....:|....:.|.|...:|:|..|.::
Human   282 NDGQRMFEAAAVGSLLAGGPV--VAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFR 344

  Fly   257 RSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMIS 321
            |......||||:.|||::..::.||||||.|:|::.:.|:|:||...:..:.|..:  ...|:..
Human   345 RKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQS--ITVGVAP 407

  Fly   322 KLSLFLSLVTY---VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFL 383
            .:.:..|:||:   :..|..:|:.:.|.|.:.::.:..:|..: |.::....|..|..:|.|...
Human   408 IVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVT-PFSVKSLSEASVAVDRFKSLF 471

  Fly   384 FQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQ-------------- 434
            ...|      ||..|....:|.          .|.|:|:.|:     :||.
Human   472 LMEE------VHMIKNKPASPH----------IKIEMKNATL-----AWDSSHSSIQNSPKLTPK 515

  Fly   435 --------------------------------------------KKQEKRHRH---------IED 446
                                                        :::|.:|.|         :..
Human   516 MKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHS 580

  Fly   447 VSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILF 511
            :..:.|:.:.|||.|:||:||::|:..|||::.::.||:.::|..:|..|:.|:|..:|||||||
Human   581 IDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILF 645

  Fly   512 TEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDD 576
            .:.|||:||..||..|.|..|:..||..|.|.:||.||:|||||:.|:|||||:|....||:|||
Human   646 GKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDD 710

  Fly   577 PLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIR 641
            ||||:|:||...:.:..:.:.|..|..:.|||::|.|...|.::.::.|.|:.:|.::.|..|..
Human   711 PLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775

  Fly   642 FRMSVANDVEVAKLRAMRTDSVYEEPEPRK----------SLSQEEHMDRHEIEQQFKEQQQIGS 696
            ...::.|::.:.:...:..:|..|....:|          |:.:|:.:...|.:....|::..||
Human   776 DYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS 840

  Fly   697 VKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKW----------ATWEET---EPN 748
            |....|..|.:..|.||..::|:.:|::...|.|....:||.|          ....||   :..
Human   841 VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSM 905

  Fly   749 QHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFT 813
            :..|..:|:.:      :|...:...||...:|...|...|||.|.|:||:||:.::|:.|.||.
Human   906 KDNPHMQYYAS------IYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD 964

  Fly   814 LATSGRILNRFSSDVLAIDVNLP-QAMMDSIEFAVNALAV---LAVVSTANIWLLI---PATVVV 871
            ...:||||||||.|:..:||.|| ||.|    |..|.:.|   :.:::....|.|:   |..::.
Human   965 TTPTGRILNRFSKDMDEVDVRLPFQAEM----FIQNVILVFFCVGMIAGVFPWFLVAVGPLVILF 1025

  Fly   872 ALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALN-GTKYMERDFHYYQ---NE 932
            ::|:....:.|   |.|||::.|::||..||..::.:|||||.|.| |.:::    |.||   ::
Human  1026 SVLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFL----HRYQELLDD 1083

  Fly   933 NTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAG 997
            |.:..:|.....|..|...|||.:  .|..|...::...|........||||:.:::|..:.|..
Human  1084 NQAPFFLFTCAMRWLAVRLDLISI--ALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT 1146

  Fly   998 MRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILK 1062
            :|...|.|...|||||:..|:...|..|....::......||..|::.|.:..:||..:.|.:||
Human  1147 VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLK 1211

  Fly  1063 GLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGH-ISIDGFETSQLGLHDLRRRISIIPQD 1126
            .::|||:.:|||||||.|.:||||:..|||||..::|. |.|||...|.:||.|||.::|||||:
Human  1212 KVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQE 1276

  Fly  1127 PVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLA 1191
            ||||||::|.|||||.:.|::::|.|||...:||.::.|...:...:.:.|.|||:|:|||:|:|
Human  1277 PVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIA 1341

  Fly  1192 RALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVV 1256
            |||||..||||:|||||.:|.|||.||||.|...||.||:||||||||||:.:||:||:..|:||
Human  1342 RALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVV 1406

  Fly  1257 ELGHPHELLHN 1267
            |...|..||.|
Human  1407 EFDTPSVLLSN 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	431/1376 (31%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	431/1372 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		0/36 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		5/32 (16%)