Protein Alignment CG11898 and abcc12

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_002937916.3
• Gene: abcc12 / 100493828
• XenbaseID: XB-GENE-6465370
• Length: 1430
• Species: Xenopus tropicalis
• Alignment Length: 1432
• Identity: 428/1432 - (29%)
• Similarity: 699/1432 - (48%)
• Gaps: 204/1432 - (14%)

  Fly     3 AVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQ-RNLDPSDLYETEPSLESTQVS-SFLLGHWE 65
            |.|  |..:|:..|..||.....|...:..|..: ..|..:||:.. |..||::.: ..|...||
 Frog    24 ATH--RNQHPIDNAGLFSFMTLNWITPLARKAYKLSELQMNDLWSL-PFHESSETNCQRLQSLWE 85

  Fly    66 QELKR--SKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTT-----QPLMLGGLVSFFSESTGKI 123
            :||:.  .:...|.::.    |.|.....:.:.:::.:..|     ..:.:..|:.:     ...
 Frog    86 EELQNHGKRKASLSLVL----WRFCRTRSLLAFLSLIITMTASFIGPAIFIRALLEY-----ANT 141

  Fly   124 TKHS---AYLYAMGVVLCSLISGLFF--HPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSG 183
            .||.   ..:.|.|:....|:....|  |..|.|  |.|.|::.|...|.::|.|::..:.|..
 Frog   142 LKHDLRYGLILASGIFAAELVRSWSFALHWAMNY--RTGVRLKGAVLALAFKKMLKLKQSNDIR- 203

  Fly   184 VSGYAISLMATDLPTFNE--SFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQA 246
             :|..:::.::|.....|  |..|.  |..||:.|::.:......:|..|::|....:.|.|...
 Frog   204 -TGELLNMCSSDGQRLFEAASIGCM--LAAGPVIGIMGLVYTALFLGPSALLGSSVFIIFYPFMM 265

  Fly   247 WAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIY 311
            .|::..|.:::....|.|.||:|||||:.:::.|||||||.:|...|..:|.||...:..:.|:.
 Frog   266 LASKLTAYFRKKCIVVTDRRVRLMNEILNSIKFIKMYAWENTFRNKIQDIRSEEKTFLEKAGYVQ 330

  Fly   312 AGLQCTGMISKLSLFLSLVTYVF---TGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETF 373
            :  ..:|:...:.:..|:.|:..   .|..:.:.:.|.|.:.::.:. |.|...|||:....|..
 Frog   331 S--ITSGVAPVVVVVASVCTFTLHMALGYNLNAAEAFTVVTVFNSMT-SALKMIPLAVKAASEAS 392

  Fly   374 VVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQE 438
            :..:|.:......|:    .:.|.:....| :..:|.|......::|:|.|:.|...: :||::|
 Frog   393 ISISRFQKLFLMEES----DMRNNQRLLSN-DLIDFSGAYFSWSSDVRSSTLEKQKEA-EQKQEE 451

  Fly   439 KRHRH----------------------------------IEDVSFQAQDQQFVGIVGTVGAGKST 469
            .:...                                  :.:::|..|..:.:||.|:||:||::
 Frog   452 FKETQNLINGHYLFSSSESKQIVNGTNASEYIVCEHKAALININFTVQKSKLIGICGSVGSGKTS 516

  Fly   470 LLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVE 534
            |:..|||::.::.|:|.|:|.::||.|:.|:...|||:||||.|.|.|::|..||:.|.|..|:|
 Frog   517 LILSILGQMTLLEGTVTVSGRIAYAAQQAWIFNESLRENILFGEEYKEKKYQRVLKTCCLYPDIE 581

  Fly   535 QLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLS 599
            .||.||.|.:||.|.:|||||:.|:|||||:|.:..:.||||||||||..|...|..:.:...:.
 Frog   582 SLPHGDLTEIGERGTNLSGGQRQRISLARALYSERSVVLLDDPLSAVDVQVGAQLFKKAIKHGMM 646

  Fly   600 KKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKK-----LIRFRM-----SVANDVEVAK 654
            .:|.:.|||::|.|...|.:::::.|.|:.||.::.|.|     .:.|:.     |:.:||:.:.
 Frog   647 NRIVLFVTHQLQYLVECDEVLMMKNGSIAEQGTHEELMKYQGDYAVLFQSMQQVNSIKSDVQCSP 711

  Fly   655 LRAMRTD---------SVYEEPEPRKSLS------------------------------------ 674
            ::..:.|         :|.::.:.:.:||
 Frog   712 MKYEQLDRQVTSSHHATVVQQSKEQGTLSELTNQEETGHFTSEDVSADHLTHKSEMVNRDFMVTD 776

  Fly   675 --------------QEEHMDRHE-------------IEQQFK-----EQQQIGSVKLQTYKEYFK 707
                          ||:..|..|             .|:|.:     |::..|||....|..|.|
 Frog   777 GQITGCKQADQYGDQEDDADEDEKGSVLGNTIIVNNNERQNRDLMEPEEKGCGSVPCPIYWVYIK 841

  Fly   708 VLGHPLVVVLILLMFVVARSSEATMDIFLSKW----------ATWEETEPNQH---EPIPEYHRT 759
            ..|..|..||..::|:....|.|..:.:||.|          .|...|..:.:   .|..|::
 Frog   842 AAGGALFCVLNAVLFIFTTGSMAFSNWWLSYWIKQGSGNTSVVTSNVTLSSDNMSDNPDLEFY-- 904

  Fly   760 RLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRF 824
                :.:|...:...|.|..:|.:.|...||:.|.::||||||.|:.:.:..|.....|||||||
 Frog   905 ----IYVYISTLAAVLGFRFIRGYVFVKSTLKASTKLHDQLFQKVLHSPLKLFDTTPLGRILNRF 965

  Fly   825 SSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLI---PATVVVALLYGCRCLYIGASR 886
            :.|:..:|..||..:...|:..:..|..|.::|....|.|:   |.:::..|:.....:.|   |
 Frog   966 TKDMDEVDARLPCQLEQLIQNMILVLFCLGMISFVFPWFLVSVLPLSILFFLINKVSRVLI---R 1027

  Fly   887 SLKRIETISRSPIYSHTNATFKGLATIRALN-GTKYMERDFHYYQNENTSALYLHVSINRAFAFW 950
            .|||::.||:||..||..|:..|:.||:|.| .|.::.| |....:.|....:|....:|..|..
 Frog  1028 ELKRLDNISQSPFLSHVTASLHGITTIQAYNKNTDFILR-FQKLLDINQVPCFLFSCASRWLAVR 1091

  Fly   951 TDLICVLYILAVTFSFLLFDKH--RGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVER 1013
            .|||.::.|...:...:|...|  ..|    .||||:.:::|..:.|..:|...|.|...|||||
 Frog  1092 LDLISMIVITLTSVCIVLMHGHIPPAY----AGLAISYAVQLTGLFQYTVRLVTETEARFTSVER 1152

  Fly  1014 VMEYV-NIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIV 1077
            :..|: |:.||...:.:|..  ||.||..|.:.|.::.:||.:..|.:||.::|:||.:||||||
 Frog  1153 INHYIKNLESEEPLKAKEIT--PKTWPQEGAITFENVEMRYRDKLPLVLKNISFSIRPKEKIGIV 1215

  Fly  1078 GHTAAGKSSIVHALFRLAHI-NGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPF 1141
            |.|.:||||:...||||..: .|.::||.|..:.:||.:||.::|::|||||||.||:|.||||.
 Frog  1216 GRTGSGKSSLGMVLFRLVDLAGGSVTIDNFCINTIGLKNLRGKLSVLPQDPVLFVGSIRSNLDPL 1280

  Fly  1142 EEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEA 1206
            ...||||:|.|||...:|:.||.|...:|..:.:.|:|||:|:|||:|:||||||.:|:|::|||
 Frog  1281 NLHTDEEVWNALERTHMKQHVSKLVGKLNYEVSENGSNFSVGERQLLCMARALLRSSKVLLLDEA 1345

  Fly  1207 TANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGY 1271
            ||.:|.|||.||||.:...|..||||.|||||:|::..||:||:|.|::||...|..||.|:...
 Frog  1346 TAAIDNETDALIQETVKEAFHDCTVLIIAHRLNTILHCDRIMVMDKGKIVEFEKPSVLLSNKKSR 1410

  Fly  1272 LH 1273
            .|
 Frog  1411 FH 1412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	423/1419 (30%)
		ABC_membrane	92..358	CDD:294371	63/280 (23%)
		ABCC_MRP_domain1	423..626	CDD:213217	82/236 (35%)
		ABC_membrane	762..988	CDD:294371	70/231 (30%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	111/219 (51%)
abcc12	XP_002937916.3	MRP_assoc_pro	27..1415	CDD:188098	426/1427 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010