Protein Alignment CG11898 and abcc4

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_002939329.2
• Gene: abcc4 / 100491006
• XenbaseID: XB-GENE-957302
• Length: 1324
• Species: Xenopus tropicalis
• Alignment Length: 1355
• Identity: 478/1355 - (35%)
• Similarity: 771/1355 - (56%)
• Gaps: 110/1355 - (8%)

  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65
            |..|.:..:.||...|||.||.||.|...:.:.|.:|.|:..|:||..|...|.::...|..:||
 Frog     1 MQPVPKGSKANPSQHANFCSKIFFWWLNPLFILGHKRKLEEDDMYEVLPEDASRKLGEELQWYWE 65

  Fly    66 QELKRS-----KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFS--ESTGKI 123
            :||:::     ||.:.:.|.:.: |.......:::....::...||:.||.::|:|.  ::....
 Frog    66 KELQKAQNEGRKPRLTKAIIRCH-WKTFSVLGLFTFFEESIRVVQPIFLGNVISYFERYDANDSA 129

  Fly   124 TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYA 188
            ...:||:.|..:..|:||..:..|.:..:|.|.|.::|:|...::|||.||:|..|.....:|..
 Frog   130 VLANAYINAAALSACTLILAVVHHIYFYHLLRAGMKLRVAMCHMIYRKALRLSNTAMGKTTTGQI 194

  Fly   189 ISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIA 253
            ::|::.|:..|::.....|.||.|||:.:....:::..||...:.|:..::..:|||....:...
 Frog   195 VNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWMEIGPSCLAGMAVLIILMPLQLCLGKFFT 259

  Fly   254 RYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYA-GLQCT 317
            ..:..:|...|.|::.|||:|:.|::|||||||:||.:|:..:||:|::.:..|:|:.| .|...
 Frog   260 SLRGKTAAFTDTRIRTMNEVISGMRIIKMYAWEQSFTELVNNIRKKEINKVLRSSYLRALNLASF 324

  Fly   318 GMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDF 382
            .:.||:.||::..|||..|:::::.:||:..|.|..:..::...:|.|:....|..|...|:|:|
 Frog   325 FVASKIILFVTFTTYVLLGNVISASRVFVAVSLYSAVRLTVTLFFPSAVERASEAKVSIRRIKNF 389

  Fly   383 LFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHIEDV 447
            |...|        .||.|.:.||...          |...:.:..::..||:..:...   ::::
 Frog   390 LLLDE--------IFKPALELPEENE----------ENLLVQIQDVTCYWDKTLEIPT---LQNI 433

  Fly   448 SFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFT 512
            |...:..:.:.::|.||||||:||..:||||....|.|::.|.::|..|:||:..|::|.||||.
 Frog   434 SCSVRPGELLAVIGPVGAGKSSLLSAVLGELPKDKGFVDIRGRIAYVSQQPWVFSGTVRSNILFG 498

  Fly   513 EPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDP 577
            :.|.:::|.:|||||.|.:|:.||..||.|.:|:.|.:|||||||||:||||||:.|||||||||
 Frog   499 KEYVQEKYDKVLRVCALKKDMLQLDDGDLTIIGDRGVTLSGGQKARVNLARAVYQDADIYLLDDP 563

  Fly   578 LSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRF 642
            |||||:.|.:.|.::|:.:.|.||:.|||||::|.|.....:::|:.||:..:|.:..|
 Frog   564 LSAVDAEVGRHLFEKCICQALRKKLCILVTHQLQYLSAAKQILILKEGRMVGKGTFQEL------ 622

  Fly   643 RMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQF------------------- 688
               :.:.::.|        |:.:..|..:|.|||..:.:....:.|
 Frog   623 ---LQSGIDFA--------SLLKSEEEEQSQSQEGQLIKSSRNRTFSQSSVWSQDSTVQSHKEGA 676

  Fly   689 --------------KEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKW 739
                          :|.:..|:|..:.||:||......|::.::||:.::::.:....|.:||.|
 Frog   677 TDNLAAEPVLTAIPEESRSEGTVGFKVYKKYFTSGSSYLMLFVVLLLNILSQVTYVLQDWWLSYW 741

  Fly   740 A--------------TWEETEPNQHEPIPEYHRTRLRMMI-LYTFLILCTLIFYVLRTFGFFMMT 789
            |              |..:||           :..|.:.: :|..|.:.|:||.|||....|.:.
 Frog   742 ANEQGKLNITSGTNSTGSKTE-----------QLDLTLYLGVYAGLTVATIIFGVLRCLLVFHVL 795

  Fly   790 LRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLA 854
            :..:..:|:|:||.:::|.:.||.....||||||||.|:..:|..:|...:|.::..:..|.|:|
 Frog   796 VCAAQALHNQMFQSLLKAPVLFFDRNPIGRILNRFSKDIGHLDDLMPFTFLDFMQVLLQILGVIA 860

  Fly   855 VVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGT 919
            |......|:|||...:|.:.|..|..::..||.:||:|:.:|||::||.:::.:||.||||....
 Frog   861 VAVAVIPWILIPLLPLVIVFYFLRRYFLDTSRDIKRLESTTRSPVFSHLSSSLQGLWTIRAFKAE 925

  Fly   920 KYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAI 984
            |..:..|...|:.::.|.:|.::.:|..|...|.||.::::|:.|..::..::..  :|.||||:
 Frog   926 KRFQDLFDAQQDLHSEAWFLFLTTSRWLAVRLDAICAVFVIAIAFGSIILAENLD--AGQVGLAL 988

  Fly   985 TQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDL 1049
            :..|.::...|.|:||:.|:||:|.|.||||||..:..|..:|::...  |..||:.|.:.|.::
 Frog   989 SYGMTIMGSFQWGVRQSAEVENLMISAERVMEYTQLEKEAEWESKNPP--PADWPNKGMITFENV 1051

  Fly  1050 RLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGHISIDGFETSQLGLH 1114
            ...||..||.:|:.|...||.:||:||||.|.|||||::.||||||...|.|.||.:.||:||||
 Frog  1052 NFSYSLDGPVVLRHLNALIRPKEKVGIVGRTGAGKSSLIAALFRLAEPEGKIWIDKYLTSKLGLH 1116

  Fly  1115 DLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGAN 1179
            |||:::|||||:||||:|::|.|||||:|..|||||..||.|:|||.|..|...|..:|.:.|:|
 Frog  1117 DLRKKMSIIPQEPVLFTGTMRKNLDPFDEHADEELWDVLEEVQLKEAVEELPGKIETQLSESGSN 1181

  Fly  1180 FSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDN 1244
            ||:|||||||||||:||:|:|||:|||||||||.||.|||:.|..|||.||||||||||:|::|:
 Frog  1182 FSVGQRQLVCLARAILRRNRILIIDEATANVDPRTDELIQKTIREKFAECTVLTIAHRLNTIIDS 1246

  Fly  1245 DRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKRV 1299
            |::||:|.|||.|...|:.||.|:....::.|::.|...|..|...|:|.|.|::
 Frog  1247 DKIMVLDAGRVKEYDEPYLLLQNKESLFYKMVQQVGKAEATALNEAAKQVYLKKI 1301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	467/1314 (36%)
		ABC_membrane	92..358	CDD:294371	78/268 (29%)
		ABCC_MRP_domain1	423..626	CDD:213217	88/202 (44%)
		ABC_membrane	762..988	CDD:294371	72/226 (32%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	132/218 (61%)
abcc4	XP_002939329.2	PLN03130	2..1289	CDD:215595	472/1340 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110