Protein Alignment CG11898 and abcc2

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_004915926.1
• Gene: abcc2 / 100485020
• XenbaseID: XB-GENE-1012796
• Length: 1552
• Species: Xenopus tropicalis
• Alignment Length: 1432
• Identity: 448/1432 - (31%)
• Similarity: 709/1432 - (49%)
• Gaps: 222/1432 - (15%)

  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65
            :|..:|..:.||...|:|.|:..|.|...|:|||.::.|:..||:|.....::..:......|.:
 Frog   192 ISEKNESTKENPELTASFLSRITFNWYNSIVVKGYKKPLEMEDLWELNEEDKTKNMYEIFEKHMK 256

  Fly    66 QELKRSKPNV---------------LRMIFKAYG------------------------------W 85
            .:::::|.::               :..|.||..                              |
 Frog   257 HDVRKAKKDLEKRKNKRKQKESGIEMNGISKAQSQDILVMEEKKKEKKKKEKSIDGTAKDYPKRW 321

  Fly    86 ----------SFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKH--SAYLYAMGVVLC 138
                      |.:..|.::.::...:....|.:|..:|:|    |...::|  ..:.||:.:::.
 Frog   322 LIKTLIKTFPSTLLTSAIFKLLHDLLAFVSPQILKVMVTF----TADPSQHQWQGFFYAVLLLVT 382

  Fly   139 SLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESF 203
            :|:.......:....|.:|.|||......||:|.|.||.|.......|..::||:.|...|.:..
 Frog   383 ALLQSFLLQQYFHGCFVLGMRVRSLLMAAVYKKALTVSNAIRKESTVGETVNLMSADAQRFMDLT 447

  Fly   204 YCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVK 268
            ...|.||..||:..:.:..:::.:|...:.|||.::..||:.|..|....:.:..:....|:|:|
 Frog   448 NFIHLLWSSPLQIAISIVFLWEELGPSVLAGLGVMILLIPINAVLATVSRKLQMKNMKNKDKRMK 512

  Fly   269 LMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMISKLSLF------- 326
            :||||:..::::|:||||.||...:.::|::|:..:...||:::          :|||
 Frog   513 IMNEILNGIKILKLYAWEPSFENQVQEIREKELKDMLHFTYLHS----------VSLFVFTCAPF 567

  Fly   327 -LSLVTY-----VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQ 385
             :|:.|:     |...:::.::|.|...|.::.|...|. ..|:.|:..|:|.|.:.|::.:|
 Frog   568 LVSVATFAVYVAVDPSNVLNAEKAFTSISLFNILRFPLA-MLPMLISSMVQTSVSSARLEKYL-- 629

  Fly   386 HENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVK---SITVHKLSASWDQKKQEKRHRHIEDV 447
                  ||        ||.:       |...:.:..   ::.....:.||    :|..:..:.:|
 Frog   630 ------GG--------DNLD-------TSAIRCDPNIDAAVQFSDATFSW----EEDANPAVNNV 669

  Fly   448 SFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFT 512
            :...::...|.:||.||:|||:|:..:|||:|.:.|.:.:.|.::|.||:.|:...:|::||||.
 Frog   670 NLDIKEGNLVAVVGGVGSGKSSLVSAMLGEMDHVGGYINIKGSIAYVPQQAWIQNATLKNNILFG 734

  Fly   513 EPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDP 577
            ...||:||.:||..|.|..|:|.||..|.:.:||.|.:||||||.|||||||||..||||:||||
 Frog   735 SKMDEERYQKVLEACALLPDLEMLPGHDESEIGEKGINLSGGQKQRVSLARAVYNDADIYILDDP 799

  Fly   578 LSAVDSHVSKMLLDRCL--NEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLI 640
            |||||:||.|.:.::.:  |..|..|.||||||.|..|:|.|.:|:|...|::..|.|..|:
 Frog   800 LSAVDAHVGKHIFEKVVGPNGLLKNKTRILVTHGVSFLKHADDIVVLVNSRVTETGSYKTLQ--- 861

  Fly   641 RFRMSVAND---VEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQF-------------- 688
                  ||:   .|..:|.|.:.|....|.........|:..|:.|..:..
 Frog   862 ------ANNGAFAEFLRLYAKQNDQTDNEATVFTGEDDEDDGDQVETAEVIEDIVASTVKRENSM 920

  Fly   689 ----------------------------------------KEQQQIGSVKLQTYKEYFKVLGHPL 713
                                                    ||..:.|.||.:.|.:|.:.:|...
 Frog   921 RQRKRSSVSMNGTLRRSVKDVTKKKTGIGSNDTKGQKLIEKETVETGKVKFKLYLKYLRAVGWGF 985

  Fly   714 VVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTF--LILCTLI 776
             ...|.:.:::..::....:|:||.|....|...|...|..:      |.|.:..|  |.:...:
 Frog   986 -SFWIFVSYILQNAAFVGQNIWLSDWTGDAEKYYNITYPASQ------RDMRVGVFGALGVAQAL 1043

  Fly   777 FYVLRTFGFFMMT---LRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQA 838
            |.:|   |.|:::   :|.|..:|.||...::|..|.||....:|||:|||:.|:|.:|..:|.:
 Frog  1044 FVLL---GAFLVSGGAVRASRMLHTQLLHNILRVPMRFFDTTPTGRIVNRFAKDILTVDETIPMS 1105

  Fly   839 MMDSIEFAVNALAVLAVVSTANIWLLIPATVVVAL---LYGCRCLYIGASRSLKRIETISRSPIY 900
            ....|...:..:..|.::..|.   .|.|.|:|.|   .|..:..|:..||.|:|:::::|||||
 Frog  1106 FRSWIACFLGVIGTLFIICLAT---PIFAAVIVPLAIFYYFVQRFYVTTSRQLRRLDSVTRSPIY 1167

  Fly   901 SHTNATFKGLATIRALNGTKYMERDFHYYQNENT-----SALYLHVSINRAFAFWTDLICVLYIL 960
            ||...|..||:.|||     |..:|.....||:|     .::|..:..||..|...:.:   ..|
 Frog  1168 SHFGETVSGLSVIRA-----YGHQDRFLQHNEDTIDNNQKSVYSWIVSNRWLAIRLEFV---GNL 1224

  Fly   961 AVTFSFLLFDKHRGYY-SGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEP 1024
            .|.|:.|.....||.. ||.|||:|:.::.:.......:|.|.|||..:.:||||.||:.:..|.
 Frog  1225 TVFFAALFAVLGRGTVDSGTVGLSISSALNITQTLNWLVRMTSELETNIVAVERVDEYIKVEREA 1289

  Fly  1025 AYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVH 1089
            .:  .|....||.||..|.:.|.|.::||......:|:|::.||...||:||||.|.|||||:.:
 Frog  1290 QW--VEDHRPPKDWPEKGVVQFVDYKVRYRPELDLVLQGISCTINSMEKVGIVGRTGAGKSSLTN 1352

  Fly  1090 ALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLAL 1153
            .:||:.. ..|.|.|||.:.:.:||||||::::|||||||||||:||.|||||.:.|||::|.||
 Frog  1353 CIFRIIESAGGKIMIDGLDIASIGLHDLRQKLTIIPQDPVLFSGNLRMNLDPFNQYTDEDIWKAL 1417

  Fly  1154 EAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLI 1218
            |...||.||..|::.:...:.:.|.|.|:||||||||||||||::||||:|||||.||.||||||
 Frog  1418 ELSHLKPFVEGLQEKLFHEVSEGGENLSVGQRQLVCLARALLRKSKILILDEATAAVDLETDNLI 1482

  Fly  1219 QEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGVGT 1283
            |..|.::||.||||||||||||:||:.|:||:|.|:::|.|.|.||| .|.|:.....:..|:.:
 Frog  1483 QRTIRSEFADCTVLTIAHRLHTIMDSSRLMVLDAGKIIEFGSPDELL-QRQGHFFSMAKDAGIDS 1546

  Fly  1284 AQ 1285
            .|
 Frog  1547 TQ 1548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	442/1405 (31%)
		ABC_membrane	92..358	CDD:294371	67/280 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	90/204 (44%)
		ABC_membrane	762..988	CDD:294371	75/239 (31%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	123/219 (56%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	446/1426 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920