DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11898 and tap1

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_002665053.1	Gene:	tap1 / 100333043	ZFINID:	ZDB-GENE-050517-43	Length:	731	Species:	Danio rerio

Alignment Length:	631	Identity:	155/631 - (24%)
Similarity:	288/631 - (45%)	Gaps:	80/631 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   689 KEQ-QQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEP 752
            ||: ::.|...||....|.|........|...:  |::...|..:..:..|...|     ..:|.
Zfish   137 KERTEKKGKASLQRLLGYMKPFSGRFAAVFFFV--VISSLGEMAIPHYTGKMTDW-----IMNED 194

  Fly   753 IPEYHRTRLRMMILYTFL-----ILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFF 812
            .||.....:.:|.|.|.:     .:|.||:.:..:        ||...|...:||.|::..:.||
Zfish   195 EPEAFNHAITVMTLMTIMSAVCEFVCDLIYNITMS--------RIHTSIQGLVFQAVLKQDIAFF 251

  Fly   813 TLATSGRILNRFSSDVLAIDVNLPQAM------MDSIEFAVNALAVLAVVSTANIWLLIPATVVV 871
            ..||:|.|::|.::|...:..:|.:.:      ...:.|...::.:|:........|.:|...::
Zfish   252 DKATTGDIVSRITTDTNTMSESLSEKLSLLMWYFMRVIFLFGSMLMLSTRLCCFTLLGLPVIWII 316

  Fly   872 ALLYG--CRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRAL-NGTKYMERDFHYYQN-- 931
            ..::|  .:.|......||.:...::        ..||..:.|:|:. |.....||    |:.
Zfish   317 PEIFGRFYQKLSAQVQDSLAKANEVA--------TETFSSMKTVRSFANEDGETER----YRKCL 369

  Fly   932 ENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYY-----------SGDVGLAIT 985
            |:|.||....:...|.:.||:   .:..||:..|.|       ||           |||:...:.
Zfish   370 EDTFALNKVEAAAYAVSTWTN---SMSSLALKVSIL-------YYGGRLVTGSDVSSGDLVSFVL 424

  Fly   986 QSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLR 1050
            ..::.....:..|.....::..:.:.|::.|||:  .:|....:.|: .||  ...|.:.||::.
Zfish   425 YELQFTSAVEVLMSYWPHVKKAVGASEKIFEYVD--RKPDVPPDGSL-APK--TLKGHVQFRNVT 484

  Fly  1051 LRYSNH-GPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGL 1113
            ..|... ...:||.::..::..:...:||.:.:||:::|..|.|... .||.|.:|  :...|..
Zfish   485 FAYPKRPDTDVLKNVSLELKAGKITALVGPSGSGKTTVVSLLERFYQPQNGEILLD--QKPLLSY 547

  Fly  1114 HD--LRRRISIIPQDPVLFSGSLRFNLDPFEEK-TDEELWLALEAVKLKEFVSNLKDGINCRLHD 1175
            .|  |..:||::.|:||||:.|:|.|:...:|. |:||::.|.......:|:|:|..|.:....:
Zfish   548 KDQYLHEKISVVSQEPVLFARSVRENIKYGKENATNEEIYAAARLANAHDFISSLPKGYDTDAGE 612

  Fly  1176 CGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHT 1240
            .|...|.||:|.:.:||||:::.:||::|:||:::|.|:::.:..|:..:...||||.|:|||..
Zfish   613 KGGQVSGGQKQRIAIARALIQKPQILVLDDATSSLDTESEHRVYSALKKELQSCTVLLISHRLSG 677

  Fly  1241 VMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGVGTAQH 1286
            |.:.|.::.:..|.:||.|: |:.|.::.|:...||::.  .||.|
Zfish   678 VENADHILFLREGELVEEGN-HQQLLDKQGFYAEFVKQQ--NTAIH 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	149/611 (24%)
		ABC_membrane	92..358	CDD:294371
		ABCC_MRP_domain1	423..626	CDD:213217
		ABC_membrane	762..988	CDD:294371	53/252 (21%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	70/223 (31%)
tap1	XP_002665053.1	3a01208	42..712	CDD:273363	150/619 (24%)
		ABC_membrane	166..433	CDD:279056	60/303 (20%)
		P-loop_NTPase	467..692	CDD:304359	70/229 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910