Protein Alignment CG11898 and abcc10

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_001135594.1
• Gene: abcc10 / 100216149
• XenbaseID: XB-GENE-6465377
• Length: 1501
• Species: Xenopus tropicalis
• Alignment Length: 1351
• Identity: 439/1351 - (32%)
• Similarity: 694/1351 - (51%)
• Gaps: 154/1351 - (11%)

  Fly     7 QRQPNPVTKANFFSKWFFIWTREILVKGLQRNL-DPSDLYETEPSLESTQVSSFLLGHWEQELKR 70
            :||.......::.|::|::|...:|.:|.:..| .|.|:......|.:.::..    |::   .:
 Frog   219 ERQHPAEDGESWLSRFFYLWLNPLLRQGARGGLKHPGDVLLLPHCLGTARICQ----HFQ---SK 276

  Fly    71 SKPNVLRM---IFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYA 132
            |...:||:   :..::|..:....:: .:.|:.:....||:|..||:|...:...::  ...||.
 Frog   277 SSSTILRLLPTLHASFGARYYALGLL-KLGAVTLAFLGPLLLNLLVNFMEAADEPLS--WGILYT 338

  Fly   133 MGV----VLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVS-GYAISLM 192
            :|:    .|.:|:...|.|...|.:..|.:.|..:    ||||.:| .|....:|.| |..::.|
 Frog   339 LGLFSSCFLAALLQNQFTHEVNKLILAVRASVLTS----VYRKAIR-GVGTGLAGFSKGEIVNFM 398

  Fly   193 ATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKR 257
            :||....:.....|||:|..||:..|.:|::|..:|...:.|||..|..:|:....|..|..|..
 Frog   399 STDADRISNFCRSFHEVWSLPLQFSVTLYLLYLQVGIAFLGGLGLAVLLLPINKVIANRIVDYNS 463

  Fly   258 SSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRG-------STYIYAGLQ 315
            ...:..|.|||||.|:::.|:::|.|.|||.||:.:..:|::|:.|:|.       ..|::|.|.
 Frog   464 DLLNHKDARVKLMTELLSGMRVVKFYTWEKHFAEAVTSLREKELRSLRALKMLDAVCVYLWAALP 528

  Fly   316 CTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVK 380
            .  :||    .::.:|||..|..:|:.|||...:....| ...|:::|..:|..:|..|...|::
 Frog   529 V--LIS----IITFITYVLLGHQLTAAKVFTALALVGML-ILPLNNFPWVLNGVLEAKVSLERIQ 586

  Fly   381 DFLFQHENPADGGVHNFKEAEDNPEHG--NFFGRTHKPKAEVKS-ITVHKLSASWDQKKQE---K 439
            .|:                  |.||..  |::  :.:|.|:..| :.:...:.||..::.|   .
 Frog   587 LFM------------------DLPEQDLLNYY--SQEPPADPSSALELRSAAFSWMPEESEDSGS 631

  Fly   440 RHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGEL-----DIISGSVEVNGVLSYAPQEPW 499
            ....||.:|  .|....||:||.||.|||:||..:.|||     ::.:...|:.  ..:|.||||
 Frog   632 LQLFIEHLS--VQKGVLVGVVGKVGCGKSSLLAALTGELSRSGGELFASHQELG--FGFAAQEPW 692

  Fly   500 LLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARA 564
            :...::|:||||.:.::.:.|..||..|.|:.|:..||.||.|.|||.|.:||||||||::||||
 Frog   693 IQFATIRENILFGKEFNGKLYQGVLEACALNDDLSILPSGDQTEVGENGVTLSGGQKARLALARA 757

  Fly   565 VYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISV 629
            ||:..|||||||||:|||:.|:..|:::|:...|..|.|||.|||.:||...|.::|:|||::..
 Frog   758 VYQDKDIYLLDDPLAAVDADVAAHLMEKCILGILKNKTRILCTHRTELLDKADIVLLMEGGKMVG 822

  Fly   630 QGHYDALKKLIRFRMSVANDVEVAKLRAMR--TDSVYEEPEPRKSLSQEEHMDRHE-------IE 685
            .|..|.:..|          ||.::.|..|  |...:......:||.::|....:|       ..
 Frog   823 SGTPDKILPL----------VESSRNRGSRGQTQMNHISQAAEQSLEEDEEEAENEGNPIQPITA 877

  Fly   686 QQFKEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQ- 749
            :..:|::|.|:|.||.|..|:|.:|..|...::|.:|:: ::|....|.:||.|.:..:..|..
 Frog   878 EVGQEEKQEGAVALQVYWAYWKAVGGCLAGSVLLALFLM-QASRNISDWWLSHWISSLQDSPRNV 941

  Fly   750 -----------------------HEPIPEYHRTRLRMMILYTF-------LILCTLIFYVLRTFG 784
                                   ..||...|.......:..||       :.:...||..||.|.
 Frog   942 SLTNLTPSSFPSASLLLFSQGGLVSPISSVHSAEKNSSLDITFYLSVYGGIAVANSIFTALRAFL 1006

  Fly   785 FFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNA 849
            |.:.|:..::.||.:|...|::|.:.||.....|||:||||||:..:|.:||..:...:.|....
 Frog  1007 FALGTVHAAVVIHRRLLSSVLQATVSFFDSTPIGRIINRFSSDLYCVDDSLPFVLNIFLAFTFGL 1071

  Fly   850 LAVLAVVSTANIWLLIPATVVVALL-YGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATI 913
            |.:|.::|....|:| |..:.:.|| |..:..|..:||.|||:::|:.||||:|.:.|..||.||
 Frog  1072 LGMLVMISYGLPWIL-PVLLPLCLLYYYLQRFYRHSSRELKRLQSITLSPIYTHFSETLTGLTTI 1135

  Fly   914 RALNGTKYMERDFHYYQNENTSALYLHVSINRAFAF-------WTD----LICVLYILAVTFSFL 967
            ||   |::.:|    ::.|..|.|    .:|:...|       |.|    :|.|:.:.|::...:
 Frog  1136 RA---TRHADR----FEAECVSRL----EVNQRCMFASNAAVQWLDIRLQMIGVMVVAAISVIAI 1189

  Fly   968 LFDKHRGYYSGDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEY-VNIPSEPAYETEES 1031
            :..:.:....|.||||::.::.:..:....:....:.|.||.||||..|| ..:|||.|   |.|
 Frog  1190 IQHQRKSGDPGLVGLALSYALSITGILSGLISSFTQTEAMMVSVERTEEYSTTLPSESA---EGS 1251

  Fly  1032 VNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH 1096
            :.:...||:.|.::||::.|.|....|..|.|::|||...|||||||.|.:|||::..||||:..
 Frog  1252 LQVELDWPTNGHIEFRNVVLCYRLGLPNALDGISFTISPGEKIGIVGRTGSGKSTLFLALFRMME 1316

  Fly  1097 I-NGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKE 1160
            : .|.|.||...:..|.|..||.|::|||||..|||||:|.||||....||.|:...|:...|::
 Frog  1317 LKEGSILIDNVPSHLLNLELLRSRLAIIPQDAFLFSGSVRVNLDPLSYHTDVEILKVLDQCHLQD 1381

  Fly  1161 FVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTK 1225
            .|..: .|::..:.|.|.|||:|||||:|||||||...|||.:|||||:||.:||.|:|..|..:
 Frog  1382 VVRRI-GGLDADVGDRGKNFSLGQRQLLCLARALLTHAKILCIDEATASVDHQTDELLQRTIRER 1445

  Fly  1226 FAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFV 1276
            |...|||||||||:|:||:|||:|:..|::|||..|..|........:|.:
 Frog  1446 FRERTVLTIAHRLNTIMDSDRVLVMHAGKLVELDSPANLSKREDSNFYRLI 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	437/1339 (33%)
		ABC_membrane	92..358	CDD:294371	80/277 (29%)
		ABCC_MRP_domain1	423..626	CDD:213217	90/210 (43%)
		ABC_membrane	762..988	CDD:294371	74/244 (30%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	110/219 (50%)
abcc10	NP_001135594.1	MRP_assoc_pro	180..1484	CDD:188098	437/1337 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920