DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcb4

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001303643.1	Gene:	abcb4 / 100136865	ZFINID:	ZDB-GENE-080204-52	Length:	1275	Species:	Danio rerio

Alignment Length:	1333	Identity:	306/1333 - (22%)
Similarity:	522/1333 - (39%)	Gaps:	285/1333 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 IMAIAVHTTQPLML---GGLVSFFSEST-------------------------GKITKHSAYLYA 132
            ||::|.....|||:   |.:...|.:.|                         .|:|.|:.|...
Zfish    61 IMSMANGAVLPLMVIVFGDMTDSFVDDTLLDNLKNITLPPNFTFPETSNITLGEKMTTHAIYYSI 125

  Fly   133 MGVVLC----------SLISG--------LFFHPFMKY---LFRVGSRVRLACAGLVYRKFLRVS 176
            ||.|:.          :|.:|        :|||..||.   .|.|....:|       ...|...
Zfish   126 MGFVVLVAAYMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQL-------NTRLTDD 183

  Fly   177 VAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAF 241
            |...|.|: |..:.::..:|.||              :.|::..:    ..||...:   .|:|.
Zfish   184 VYKINEGI-GDKLGMLIQNLTTF--------------IVGIIIGF----AKGWKLTL---VILAV 226

  Fly   242 IPLQAWAARAIAR------------YKRSSADVGDERVKLMNEIIA---AMQLIKMYAWEKSFAK 291
            .||...:|..|.:            |.::.| |.:|.:..:..:.|   ..:.||.|......||
Zfish   227 SPLLGISAAVIGKVMTTFTSKEQTAYAKAGA-VAEEVLSSIRTVFAFGGQKKEIKRYHKNLEDAK 290

  Fly   292 LIGKVRKEEMDSIR------------------GSTYIYAGLQCTGMISKLSLFLSLVTYVFTGDI 338
            .:| |||....:|.                  |||.|..|....||:  |::|.:::...| |..
Zfish   291 NVG-VRKAITVNIAMGFTFFMIYMSYALAFWYGSTLILGGEYTIGML--LTIFFAVLIGAF-GLG 351

  Fly   339 VTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHN-FKEAED 402
            .||..                          ::||              :.|.|..|. |:..:.
Zfish   352 QTSPN--------------------------IQTF--------------SSARGAAHKVFQIIDH 376

  Fly   403 NPEHGNFFGRTHK---PKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVG 464
            .|:..:|....:|   .|..::...:|....|.|..|.      :..::.:....|.:.:||:.|
Zfish   377 EPKINSFSEEGYKLDVVKGNIEFKNIHFRYPSRDDVKV------LNGMNLKVMSGQTIALVGSSG 435

  Fly   465 AGKSTLLQVILGELDIISGSVEVNG-------------VLSYAPQEPWLLRGSLRDNILF-TEPY 515
            .||||.:|::....|...|||.::|             ::....|||.|...::.:||.: .:..
Zfish   436 CGKSTTIQLLQRFYDPQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDV 500

  Fly   516 DEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSA 580
            .:....:..|..:....:.:||....|.||:.|..:|||||.|:::|||:.|...|.|||:..||
Zfish   501 TQDEIEQAAREANAYNFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSA 565

  Fly   581 VDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKK------- 638
            :|:. |:.::...|::....:..|:|.||:..:|:.|.:...:.|.|...|.:|.|.:
Zfish   566 LDAE-SETIVQAALDKVRLGRTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHS 629

  Fly   639 LIRFRMSVANDVEVAKLRAMRTDSVYEEPEPRKSLSQEEHMDRH--------EIEQQFK--EQQQ 693
            |:..:|..:.:|.......|..|    |..|..|...|..:.|.        |::::.|  |:::
Zfish   630 LVNMQMFKSTEVAEEDSEEMTMD----EKSPSVSSMNERTLFRQKSRSGSEKELKEEEKPTEEEK 690

  Fly   694 IGSVKLQT-----YKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPI 753
            :.:|...|     |.|:      |.:||.||...:......|...||....|.:.|
Zfish   691 VPNVSFLTVLKLNYPEW------PYMVVGILCATINGGMQPAFAVIFSKIIAVFAE--------- 740

  Fly   754 PEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLR----------ISLRIHDQLFQGVIRAF 808
            |:.:..|.|       ..|.:|:|..:....||.:.|:          :::|:..:.|..::|..
Zfish   741 PDQNLVRQR-------CDLYSLLFAGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMRQD 798

  Fly   809 MHFF--TLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIW---LLIPAT 868
            :.::  |..:.|.:..|.::|...:. ......:.::...|..|....|:|....|   |||.:.
Zfish   799 LAWYDDTKNSVGALTTRLAADTAQVQ-GATGVRLATLAQNVANLGTAIVISFVYGWQLTLLILSI 862

  Fly   869 VVVALLYGCRCLYIGASRSLK--------------RIETISRSPIYSHTNATFKGLATIRALNGT 919
            |.:..:.|...:.:.|..:||              .||.: |:.:.....:.|:.|
Zfish   863 VPIMAVAGAIQMKLLAGHALKDKKELEQAGKIATEAIENV-RTVVSLTRESKFESL--------- 917

  Fly   920 KYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAI 984
             |.|.....|:|....|   || ....|:|...:|...|.....|...|.::....:.| |.|.|
Zfish   918 -YEENLIVPYKNAKKKA---HV-FGLTFSFSQAMIYFAYAGCFKFGSWLIEQKLMTFEG-VFLVI 976

  Fly   985 TQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYE-TEESVNLPKHWPSGGQLDFRD 1048
            :..:...:........|........|...|:..:|  ..||.: :.|..:.|..:.  |.:.|..
Zfish   977 SAVVYGAMAVGEANSFTPNYAKAKMSASHVLMLIN--RAPAIDNSSEDGDKPDKFE--GNVGFEH 1037

  Fly  1049 LRLRY-SNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQL 1111
            :..:| |.....:|:||...::..:.:.:||.:..|||:.:..|.|... ..|.:.:|..:..||
Zfish  1038 VYFKYPSRPDVPVLQGLKLRVKKGQTLALVGSSGCGKSTTIQLLERFYDPQQGRVMLDDNDAKQL 1102

  Fly  1112 GLHDLRRRISIIPQDPVLFSGSLRFNL---DPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRL 1173
            .:|.||.:|.|:.|:||||..||..|:   |...|...||:..|.:|..:..|:.||......:.
Zfish  1103 NIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQA 1167

  Fly  1174 HDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRL 1238
            .|.|...|.||:|.:.:|||:||..|:|::||||:.:|.|::.::|:|:.......|.:.:||||
Zfish  1168 GDKGTQLSGGQKQRIAIARAILRNPKVLLLDEATSALDTESEKIVQDALDKASKGRTCIIVAHRL 1232

  Fly  1239 HTVMDNDRVMVVDMGRVVELGHPHELLHNRHGY 1271
            .|:.:.|.:.||..|.|||.|...:||..:..|
Zfish  1233 STIQNADCIAVVQNGVVVEQGTHQQLLSQQGAY 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	305/1328 (23%)
		ABC_membrane	92..358	CDD:294371	71/343 (21%)
		ABCC_MRP_domain1	423..626	CDD:213217	56/216 (26%)
		ABC_membrane	762..988	CDD:294371	49/254 (19%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	75/223 (34%)
abcb4	NP_001303643.1	PTZ00265	55..1266	CDD:240339	306/1333 (23%)
		ABC_membrane	60..348	CDD:279056	67/319 (21%)
		ABC_MTABC3_MDL1_MDL2	397..634	CDD:213216	62/243 (26%)
		ABC_membrane	714..984	CDD:279056	58/302 (19%)
		ABC_MTABC3_MDL1_MDL2	1035..1272	CDD:213216	77/231 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000