Protein Alignment CG11898 and abcc3

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_001107301.1
• Gene: abcc3 / 100135090
• XenbaseID: XB-GENE-1003737
• Length: 1531
• Species: Xenopus tropicalis
• Alignment Length: 1375
• Identity: 426/1375 - (30%)
• Similarity: 690/1375 - (50%)
• Gaps: 168/1375 - (12%)

  Fly     2 SAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQ 66
            |.|.::..|.|.:.|.|.|:..|.|..::.:.|.:|.|:..||:.......|..|.:.|:..||:
 Frog   198 SPVRDEINPCPESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEK 262

  Fly    67 E------------------------------------LKRSKPNVLRMIFKAYGWSFVPASIVYS 95
            |                                    .|..:|:.|:::.:.:|..|:..|. :.
 Frog   263 EKSNLAQMQVSYSKKPEAVLNHTDEKAYESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSF-FK 326

  Fly    96 IMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRV 160
            :....:....|.:|..|::|......  .....:..|:.:.|.||:..|..|...:|.|..|.|:
 Frog   327 LFQDLLSFVNPQLLSILITFIKNKDA--PSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRL 389

  Fly   161 RLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQ 225
            |.|..|::|||.|.::.:|..|...|..::||:.|...|.:.....:.||..||:..:.:|.::|
 Frog   390 RSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQ 454

  Fly   226 LIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFA 290
            .:|...:.|:..:|..||:.|:.|.....::.......|.|:||||||:..::::|:||||.|||
 Frog   455 ALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFA 519

  Fly   291 KLIGKVRKEEMDSIRGSTYI-----YAGLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASY 350
            :.:.::|.:|::.::.:.|:     :|......::: |:.|...|| |...:|:.::|.|:..|.
 Frog   520 QKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVA-LTTFAVYVT-VDEKNILDAEKAFVSLSL 582

  Fly   351 YDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHK 415
            ::.|... |:..|..|:...:..|...|:::||...|...:.      ..:|....||
 Frog   583 FNILRFP-LNMLPQVISNLAQASVSIKRIQNFLANDELDLNA------VTKDKTLPGN------- 633

  Fly   416 PKAEVKSITVHKLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDI 480
                  :||||..:.||    .:.....:::::........|.:||.||.|||:|:..:|||::.
 Frog   634 ------AITVHNGTFSW----AKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEK 688

  Fly   481 ISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVG 545
            ..|.|.|.|.::|.||:.|:...:|:|||||....:|:.|.:||..|.|..|:|.||.||.|.:|
 Frog   689 EEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIG 753

  Fly   546 EGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCL--NEFLSKKIRILVTH 608
            |.|.:||||||.||||||||:..||:|||||||||||:||:|.:.|..:  :..|..|.|:||||
 Frog   754 EKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTH 818

  Fly   609 RVQLLRHVDHLVLLEGGRISVQGHYDALKK----LIRFRMSVANDVEV----------------- 652
            .:..|..|||:|:|..||::..|.|..|.|    ...|..:.|.|.||
 Frog   819 GISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAE 883

  Fly   653 ------------------AKLRAMRTDSVYEEPEPRKSLSQEEHMDRHEIEQQFKEQQ------- 692
                              |:.:.:|..|:..:.||..::|........:..:....:|
 Frog   884 ETLSTHTDLADNEPVANEARKKFIRQISILSDGEPSHAMSTRRRFTEKKPSENLVAKQPPTEKLI 948

  Fly   693 -----QIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATM--DIFLSKWATWEETEPNQH 750
                 :.|.||:..:.:|.|.:|   :.:.:.:.|:.:..:.|.:  :::||.|.         :
 Frog   949 QTETTETGRVKMTVFWQYMKAVG---LAISVFICFLYSCQNAAAIGANVWLSDWT---------N 1001

  Fly   751 EPIPEYHRTRLRMMI-LYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTL 814
            ||:....:...:|.: :|..|.:...:..:..:|...:..:..:.::|..|....:.....|:..
 Frog  1002 EPVINQTQQNTQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDT 1066

  Fly   815 ATSGRILNRFSSDVLAIDVNLP-QAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCR 878
            ...|||:||||.|:..||..:| ..:|....|..:...::.:|::..::.::...:.:|.::..|
 Frog  1067 TPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQR 1131

  Fly   879 CLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRA---------LNGTKYMERDFHYYQNENT 934
             .|:..||.|||:|::||||||||.:.|..|.:.|||         |:..|.         :||.
 Frog  1132 -FYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKV---------DENQ 1186

  Fly   935 SALYLHVSINRAFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYS-GDVGLAITQSMKLVLMCQA 996
            .:.|..:..||......:.:  ||: :.|..|:.|    .|.:.| |.|||:::.::::.:....
 Frog  1187 KSYYPGIVSNRWLGVRVEFVGNCVV-LFAALFAVL----GREHLSPGLVGLSVSYALQVTMSLNW 1246

  Fly   997 GMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYIL 1061
            .:|.|.:||..:.:||||.||....:|..:..|:: ..|:.|||.|:::..:..:||......:|
 Frog  1247 MVRMTSDLETNIVAVERVKEYAENETEAPWHIEDT-KPPEDWPSKGEVELSNYSVRYRAGLDLVL 1310

  Fly  1062 KGLTFTIRGEEKIGIVGHTAAGKSSIVHALFR-LAHINGHISIDGFETSQLGLHDLRRRISIIPQ 1125
            |.|...:.|.||:||||.|.|||||:...||| |....|.:.||....|::||.|||.|::||||
 Frog  1311 KNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQ 1375

  Fly  1126 DPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCL 1190
            |||||||:||.|||||.:.:|:|:|.|||...||:||:.....:.....:.|.|.|:||||||||
 Frog  1376 DPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCL 1440

  Fly  1191 ARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRV 1255
            ||||||:.:|||:|||||.:|.|||:|||..|.|:|..||||||||||:|:||..||:|:|.||:
 Frog  1441 ARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRI 1505

  Fly  1256 VELGHPHELL 1265
            .|...|..|:
 Frog  1506 AEFDTPTNLI 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	424/1368 (31%)
		ABC_membrane	92..358	CDD:294371	71/270 (26%)
		ABCC_MRP_domain1	423..626	CDD:213217	92/204 (45%)
		ABC_membrane	762..988	CDD:294371	61/239 (26%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	116/219 (53%)
abcc3	NP_001107301.1	MRP_assoc_pro	7..1530	CDD:188098	426/1375 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010