Protein Alignment CG11898 and abcc5

DIOPT Version :9

• Sequence 1: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_012818083.1
• Gene: abcc5 / 100125060
• XenbaseID: XB-GENE-986260
• Length: 1437
• Species: Xenopus tropicalis
• Alignment Length: 1384
• Identity: 434/1384 - (31%)
• Similarity: 688/1384 - (49%)
• Gaps: 183/1384 - (13%)

  Fly     8 RQPNPVTKANFFSKWFFIW----TREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGH-WEQE 67
            :..:||..|..||...|.|    .|....||   .|...|::..... ||:.::|..|.. |.:|
 Frog    97 KHQHPVDNAGLFSFMTFSWLTPMARIAYKKG---ELFFEDIWPLSKH-ESSDINSKRLEKLWLEE 157

  Fly    68 L--KRSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFS---------ESTG 121
            :  |.:..:.||.:.    |.|....::.|||.        |||..|..|..         |.|.
 Frog   158 VTEKGADESSLRSVV----WHFCRTRLIISIMC--------LMLTQLAGFIGPAFVVKSLLEYTQ 210

  Fly   122 KITKHSAY--LYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGV 184
            :.:|...|  |....:::..::............:|.|||:|.|...:.::|.|::....:.|
 Frog   211 QSSKDPGYSLLLVFALLMTEIVRSWSLALTWALNYRTGSRLRGAVLTMAFKKILKLKNIKEKS-- 273

  Fly   185 SGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLI--GWPAVVGLGTIVAFIPLQAW 247
            .|..|::.::|.....|:......|..||:  |..:.:||.:|  |....:|....:.|.|...:
 Frog   274 MGELINVCSSDGQRMFEAAAVGSLLAGGPI--VAILGMIYNVIILGPTGFLGSAVFILFYPAMMF 336

  Fly   248 AARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTY--- 309
            .:|..|.::|....|.||||:.|||::..::.||||||.|:|::.:.|:|:.|...:..:.|
 Frog   337 VSRLTAYFRRKCVSVTDERVQKMNEVLNYIKFIKMYAWVKAFSQNVQKIRENERSILERAGYFQS 401

  Fly   310 IYAGLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFV 374
            |..|:  ..::..::..|:...::..|..:|:.:.|.|.:.::.:..:|..: |.::....|..|
 Frog   402 ITVGI--APIVVVIASVLTFSVHMILGYDLTAAQAFTVVTVFNSMTFALKVT-PFSVKSLSEASV 463

  Fly   375 VANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITV-------------- 425
            ..:|.|......|      ||..|:...:|   |..       .|:|:.|:
 Frog   464 SMDRFKSLFLMEE------VHMVKKKPSSP---NLI-------IELKNATLAWDTTYASTQCSPK 512

  Fly   426 --------------------HKLSASWDQKKQEKRHRHIEDVSFQAQDQQ--------------- 455
                                |::..|.....::|.|..|:.....:.|::
 Frog   513 GTPKLKKGKKGVKGKKEKCSHEIEGSQAVLAEQKGHLLIDSDEHPSPDEETKELPVINVKLQRAL 577

  Fly   456 -----------FVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNI 509
                       .:||.|:||:||::|:..|||::.::.||:.|:|..:|..|:.|:|..:|||||
 Frog   578 YSIDLDIEKGKLIGICGSVGSGKTSLISAILGQMTLLEGSIAVSGSFAYVAQQAWILNATLRDNI 642

  Fly   510 LFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLL 574
            ||.:.:||:.|..||.||.|..|:..||.||.|.:||.||:|||||:.|:|||||:|....||:|
 Frog   643 LFGKEFDEEEYNAVLNVCCLRPDLAILPNGDLTEIGERGANLSGGQRQRISLARALYSDRSIYIL 707

  Fly   575 DDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKL 639
            ||||||:|:||...:.:..:.:.|..|..:.:||::|.|...|.::.::.|.|:.:|.::.|.||
 Frog   708 DDPLSALDAHVGNHIFNSAIRKHLKSKTILFITHQLQYLVDCDDVIYMKEGCITERGTHEDLIKL 772

  Fly   640 --------IRFRMSVANDVEVAKLRAMRTDSV---YEEPEPRKSLSQEEHMDRHEIEQQFKEQQQ 693
                    ..|::..|..:|...|:....:|:   .|:.....|:.:|:.:.:.|.:....|::.
 Frog   773 NGEYAAIFNNFQLGDAPHIEQMNLKKNLKNSLKKPLEKGNKAGSVKKEKTVKKEEGQLMQLEEKG 837

  Fly   694 IGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKW----------ATWEET--- 745
            .|||....|..|.:..|.|...::|:.:||:...|.|..:.:||.|          ....||
 Frog   838 KGSVPWSVYGAYIQSAGGPFAFLIIMTLFVLNVGSTAFSNWWLSYWIKQGSGNTTVVVHNETVVS 902

  Fly   746 ---EPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRA 807
               :.|.|.         |....:|...::..|:...:|...|...|||.|.|:||:||:.::|:
 Frog   903 NSMKDNPHV---------LFYTAIYALSMVVMLLLKAVRGIVFVKGTLRASSRLHDELFRRILRS 958

  Fly   808 FMHFFTLATSGRILNRFSSDVLAIDVNLP-QAMMDSIEFAVNALAV---LAVVSTANIWLLI--- 865
            .|.||....:||:|||||.|:..:||.|| ||.|    |..|.:.|   |.|:|....|.|:
 Frog   959 PMKFFDTTPTGRVLNRFSKDMDEVDVRLPFQAEM----FVQNVILVFFCLGVISFVFPWFLVAVG 1019

  Fly   866 PATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALN-GTKYMERDFHYY 929
            |..|:..:|:....::|   |.|||:|.|::||..||..::.:||.||.|.: |.:::.|    |
 Frog  1020 PLVVLFTILHVVSRVFI---RELKRLENITQSPFLSHITSSIQGLTTIHAYSKGNEFLLR----Y 1077

  Fly   930 Q---NENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLV 991
            |   :.|.:..||.....|..|...|:|.|  .|..|...::...|........|||::.:::|.
 Frog  1078 QELLDNNQAPFYLFNCAMRWLAIRLDVISV--SLITTTGLMIVLMHGNISPAYAGLAMSYAVQLT 1140

  Fly   992 LMCQAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNH 1056
            .:.|..:|...|.|...|||||:..|:...:..|....::...|..||..|::.|.:..:||..:
 Frog  1141 GLFQFTVRLASETEARFTSVERINHYIKTLALEAPARIKNKAPPADWPQEGEIKFENAEMRYREN 1205

  Fly  1057 GPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGH-ISIDGFETSQLGLHDLRRRI 1120
            .|.:||.::|||:.:|||||||.|.:||:|:..|||||..::|. |.|||.:.|.:||.|||.::
 Frog  1206 LPLVLKKVSFTIKPKEKIGIVGRTGSGKTSLGMALFRLVELSGGCIKIDGVKISDIGLADLRSKL 1270

  Fly  1121 SIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQR 1185
            |||||:||||||::|.|||||.:.::|::|.|||...:||.|:.|...:...:.:.|.|||:|:|
 Frog  1271 SIIPQEPVLFSGTVRSNLDPFSQYSEEQIWDALERTHMKECVAQLPLKLETEVLENGENFSVGER 1335

  Fly  1186 QLVCLARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVV 1250
            ||:|:||.|||:.||||:|||||.:|.|||.||||.|...||.||:||||||||||:..||:||:
 Frog  1336 QLMCIARVLLRRCKILILDEATAAMDTETDLLIQETIREAFAECTMLTIAHRLHTVLSCDRIMVL 1400

  Fly  1251 DMGRVVELGHPHELLHNRH 1269
            ..|:|:|...|..||.|.:
 Frog  1401 AQGQVMEYDTPSALLSNEN 1419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	433/1380 (31%)
		ABC_membrane	92..358	CDD:294371	67/281 (24%)
		ABCC_MRP_domain1	423..626	CDD:213217	82/262 (31%)
		ABC_membrane	762..988	CDD:294371	77/236 (33%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	116/219 (53%)
abcc5	XP_012818083.1	PLN03130	101..1425	CDD:215595	434/1380 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920