DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11898 and abcc6b.2

DIOPT Version :9

Sequence 1:NP_651679.2 Gene:CG11898 / 43451 FlyBaseID:FBgn0039645 Length:1320 Species:Drosophila melanogaster
Sequence 2:XP_003198194.2 Gene:abcc6b.2 / 100002917 ZFINID:ZDB-GENE-110208-2 Length:1502 Species:Danio rerio


Alignment Length:1375 Identity:449/1375 - (32%)
Similarity:706/1375 - (51%) Gaps:177/1375 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 RQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQ-----E 67
            :.|.||..|:|.||..|.|...::|||.:..|...||:.......|.::...|...|.:     :
Zfish   203 KNPCPVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICDLEKEWAKQWAKLQ 267

  Fly    68 LKRSKPN---------------VLRMIFKAYGWSFV----------P---ASIVYSIMAIAVHTT 104
            .|:|..|               :.|.:||.....||          |   ...::.::..|:..:
Zfish   268 QKKSSLNEAQTLGFKLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFSPYFLTGTLFLVIQDALMFS 332

  Fly   105 QPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVY 169
            .|.:|..|:.:..:....:.|  .||:|..:.|.|.:..||.|.:|.....||.||:.|..||||
Zfish   333 IPQVLSLLLGYVRDEDAPLWK--GYLFAFSLFLLSCLQSLFNHQYMYTCLTVGMRVKTAVMGLVY 395

  Fly   170 RKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVG 234
            ||.|.::.||..:...|..::|::.|.....:....|:.||..|:|..:.::.::|.:|...:.|
Zfish   396 RKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTLAG 460

  Fly   235 LGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKE 299
            :.|::...||..:.|:..::.:.......|||:||||||::.::::|.|||||:|.:.:...|::
Zfish   461 ITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYREK 525

  Fly   300 EMDSIRGSTYIYA-GLQCTGMISKLSLFLSLVTYVFTGD--IVTSQKVFIVASYYDHLNDSLLHS 361
            |:::::.|..:|: .:......:.|..|.....||...|  ::.:||:|:..:..:.|. :.|..
Zfish   526 ELNALKKSQILYSVSIASFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMALINILK-APLSQ 589

  Fly   362 WPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVH 426
            .|:|::..::..|...|:..||.|.|...|    :.:....||              .::|:.::
Zfish   590 LPIAMSTTMQVVVSLKRLGTFLDQDELKLD----SVQRVPYNP--------------NIESVVIN 636

  Fly   427 KLSASWDQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVL 491
            ..:.||.:.......|    ::.:.|....|.:||.||:|||:||..:|||::..||.:.:.|.:
Zfish   637 NGTFSWSKDSTPCLRR----INVKVQRGSLVAVVGHVGSGKSSLLSAMLGEMEKKSGHITITGSV 697

  Fly   492 SYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQK 556
            .|.||:.|:...:|:|||||.....:..|.:||..|.|..|:|.||..|:|.:||.|.:||||||
Zfish   698 GYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEILPARDATEIGEKGLNLSGGQK 762

  Fly   557 ARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCL--NEFLSKKIRILVTHRVQLLRHVDHL 619
            .||||||||||.:|||||||||||||:||.:.:.::.:  |..|..|.|:||||.:..|...|.:
Zfish   763 QRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSLKNKTRVLVTHGLSFLPQADLI 827

  Fly   620 VLLEGGRISVQGHY-------DALKKLIRFRMSVANDVEVAKLRAMR------------TDSVYE 665
            :::..|.|...|.|       :|..:|..|  ||:...|.|.|:..|            ||.:..
Zfish   828 LVMADGEIKEMGSYAELLSRKNAFAELKAF--SVSERKESATLKGTRKSVSFLSIKDFSTDLIRG 890

  Fly   666 E-----PEPRKSLSQEE-HMDRHEIEQQFK-EQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFV 723
            :     .:..:::|..: :.||.|:.:..: ::...|.|||:.|.|||:.:|...::.:|.| :.
Zfish   891 DLGSASIQTMEAISDPKLNQDRDEVGRLTQADKAHTGRVKLEMYVEYFRTIGLAFIIPIIFL-YA 954

  Fly   724 VARSSEATMDIFLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGF--- 785
            ..:.:....:.:||.||         .:|:  .:.|::.          ..|...|....||   
Zfish   955 FQQVASLAYNYWLSLWA---------DDPV--INGTQVN----------TDLKLGVYGALGFAQG 998

  Fly   786 ---FMMTLRISL-------RIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMM 840
               |..|:.|||       ::|..|...|:.:.|.||....||.:|||||.::.|||..:|..:.
Zfish   999 IAIFGTTVAISLGGIIASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLK 1063

  Fly   841 DSIEFAVNALAVLAVVSTANIW---LLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSH 902
            ..:.:....|.|..:|..|..:   :::|.|::.|.:   :..|:..|..|:|:|::||||||:|
Zfish  1064 IMLGYVFKLLEVCIIVLMATPFAGVIILPLTLLYAFI---QSFYVATSCQLRRLESVSRSPIYTH 1125

  Fly   903 TNATFKGLATIRA----------------LNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWT 951
            .|.|.:|.:.|||                ||.|.|..|        ..::.:|.|::        
Zfish  1126 FNETVQGASVIRAFGEQPRFILQANCRVDLNQTSYFPR--------FVASRWLAVNL-------- 1174

  Fly   952 DLICVLYILAVTFSFLLFDKHRGYYS-GDVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVM 1015
            :.:..|.:||..   :|....|...| |.||||::.|:::..:....:|...::||.:.|||||.
Zfish  1175 EFLGNLLVLAAA---ILSVMGRATLSPGTVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVK 1236

  Fly  1016 EYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHT 1080
            ||.....|..:..|:| .||..||..|.:.|:...|:|.....:.||.::.::...||:||||.|
Zfish  1237 EYAETAKEAPWTFEDS-PLPSDWPRSGSIGFQAYGLQYRKGLDWALKEISLSVNEREKVGIVGRT 1300

  Fly  1081 AAGKSSIVHALFR-LAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEK 1144
            .|||||:...:|| |....|.|.|||...:::|||:||.||:||||||||||||||.|||||:..
Zfish  1301 GAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRY 1365

  Fly  1145 TDEELWLALEAVKLKEFVSNLKDGINCRLHDC---GANFSMGQRQLVCLARALLRQNKILIMDEA 1206
            ||||:|.:||...||.|||:|.|.:|   |:|   |.|.|:|||||:||||||||:.|||::|||
Zfish  1366 TDEEVWRSLELAHLKTFVSDLPDKLN---HECSEGGENLSLGQRQLICLARALLRKTKILVLDEA 1427

  Fly  1207 TANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGY 1271
            ||.||.:||||||..|.|:|..||||||||||:|:||..||:|:|.|.:.|:..|..|: ::||.
Zfish  1428 TAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLI-SQHGQ 1491

  Fly  1272 LHRFVEKTGV 1281
            .:|...:.|:
Zfish  1492 FYRMCREAGL 1501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11898NP_651679.2 CFTR_protein 9..1268 CDD:273530 445/1359 (33%)
ABC_membrane 92..358 CDD:294371 72/268 (27%)
ABCC_MRP_domain1 423..626 CDD:213217 85/204 (42%)
ABC_membrane 762..988 CDD:294371 69/258 (27%)
ABCC_MRP_domain2 1042..1261 CDD:213211 123/222 (55%)
abcc6b.2XP_003198194.2 MRP_assoc_pro 5..1501 CDD:188098 448/1373 (33%)
ABC_membrane 320..587 CDD:294371 72/269 (27%)
ABCC_MRP_domain1 633..834 CDD:213217 85/204 (42%)
ABC_membrane 950..1215 CDD:279056 78/308 (25%)
ABCC_MRP_domain2 1262..1482 CDD:213211 123/222 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586064
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.750

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