DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11898 and abcc1

DIOPT Version :9

Sequence 1:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	1383	Identity:	449/1383 - (32%)
Similarity:	689/1383 - (49%)	Gaps:	167/1383 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQ 66
            |.|.:...|.|.:.|:|.||..|.|...::|||.:|.|:..||:......:|.:|...|:..|:|
Zfish   199 SEVVKDSNPCPESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQ 263

  Fly    67 EL--------------KRS--------------------------KPNVLRMIFKAYGWSFVPAS 91
            |.              |||                          :|::...:.:.:|..|:.:|
Zfish   264 ECVKVKRPVDKTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYFLVSS 328

  Fly    92 IVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRV 156
            : |.|:...:....|.:|..|:.|.::|:.. |.| .|.|...:.:|:.:..|....:....|..
Zfish   329 L-YKIIHDVLMFVGPEILRLLILFVNDSSAP-TWH-GYFYTALLFVCTCLQTLILQKYFHVCFVT 390

  Fly   157 GSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPTFNESFYCFHELWRGPLEGVVFVY 221
            |.|:|.|..|.||||.|.::.||..:...|..::||:.|...|.:.....:.:|..||:.::.:|
Zfish   391 GMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALY 455

  Fly   222 IIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVGDERVKLMNEIIAAMQLIKMYAWE 286
            .::|.:|...:.|:..:|..:||.|..|.....|:.:.....|.|:|||||::..::::|:||||
Zfish   456 FLWQNLGASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWE 520

  Fly   287 KSFAKLIGKVRKEEMDSIRGSTYIYA----GLQCTGMISKLSLFLSLVTYVFTGDIVTSQKVFIV 347
            .:|...:..:|:.|:..::...|:.|    ...|...:..||.| ::...|...:|:.:||.|:.
Zfish   521 LAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTF-AVYVLVDENNILDAQKAFVS 584

  Fly   348 ASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADGGVHNFKEAEDNPEHGNFFGR 412
            .:.::.|... |:..|:.|:..|:..|...|::.|| .||...|          ||.|.....|.
Zfish   585 LALFNILRFP-LNMLPMVISSMVQASVSMQRLRVFL-SHEELDD----------DNVERPAISGT 637

  Fly   413 THKPKAEVKSITVHKLSASW--DQKKQEKRHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVIL 475
            .       .||.:...:.||  |.....||      ::....:...|.:||.||:|||:||..:|
Zfish   638 P-------DSIRIADGAFSWSKDDPPTLKR------INVSIPEGALVAVVGHVGSGKSSLLSALL 689

  Fly   476 GELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGD 540
            ||:....|||.:.|.::|.||:.|:...:|:|||||.....:..|.:|:..|.|..|:|.||.||
Zfish   690 GEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGD 754

  Fly   541 STRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNE--FLSKKIR 603
            :|.:||.|.:||||||.|||:|||||....:|||||||||||:||.|.:.::.:..  .|..:.|
Zfish   755 TTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTR 819

  Fly   604 ILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIRFRMSVANDVEVAKLRAMRTDSVYEEPE 668
            :||||.:..|...|.::::..|.|:..|.|..|         :......|:.....|::..||.|
Zfish   820 VLVTHGLSFLPQADLILVMVDGEITEMGSYTEL---------LGRQGAFAEFLRTYTNTEQEEGE 875

  Fly   669 -------PRKSLSQ--------------------------EEHMDRHEIEQQFKEQQQI------ 694
                   |||.|..                          |.:.|....:.:..|..::
Zfish   876 ESLGDAVPRKGLENGGPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLTEADKA 940

  Fly   695 --GSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWA---TWEETEPNQHEPIP 754
              |.|||..:.||.|.:|.||.:..|.|.|....||..: :.:||.|.   ....|:|.:...:.
Zfish   941 NTGRVKLSVFWEYMKAIGLPLSIFSIFLFFCHHLSSLGS-NYWLSLWTDDPVVNNTQPKREMRLG 1004

  Fly   755 EYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSGR 819
            .|....:...|    .:.|   :.|..:.|..:    .|..:|..:...|:|:.|.||....||.
Zfish  1005 VYGALGISQGI----AVFC---YSVSVSVGGIL----ASRYLHQTMLYNVLRSPMSFFERTPSGN 1058

  Fly   820 ILNRFSSDVLAIDVNLP---QAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLY-GCRCL 880
            ::|||:.:...||..:|   :..|.|:...:.:.||: :::|..:.::||.   :.||| ..:..
Zfish  1059 LVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVI-LIATPLVAIIIPP---LGLLYFFVQRF 1119

  Fly   881 YIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINR 945
            |:.:||.:||:|::||||:|:|.|.|..|.:.|||....:...::.....:.|..|.:..:..||
Zfish  1120 YVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANR 1184

  Fly   946 AFAFWTDLI--CVLYILAVTFSFLLFDKHRGYYS-GDVGLAITQSMKLVLMCQAGMRQTVELENM 1007
            ..|...:.:  |:     |||:.|.....|...| |.:||:|:.::::.......:|.:.|||..
Zfish  1185 WLAVRLEFVGNCI-----VTFAALFAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETN 1244

  Fly  1008 MTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEE 1072
            :.:||||.||.:...|..::.|.| |||..||:.|.::.....|||.......:..::..|.|.|
Zfish  1245 IVAVERVKEYGDTEKEAEWKLENS-NLPPGWPTAGHIEIHKFGLRYREDLELAICDISVNIAGGE 1308

  Fly  1073 KIGIVGHTAAGKSSIVHALFRLAH-INGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRF 1136
            |:||||.|.|||||:...|||:.. ..|.|.|||...:.||||:||.||:||||||||||||||.
Zfish  1309 KVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRM 1373

  Fly  1137 NLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDC---GANFSMGQRQLVCLARALLRQN 1198
            |||||:..||||:|.:||...||.|||.|.|.:|   |:|   |.|.|:||||||||||||||:.
Zfish  1374 NLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLN---HECSEGGENLSLGQRQLVCLARALLRKT 1435

  Fly  1199 KILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHE 1263
            |||::|||||.||.|||||||..|.|:|..||||||||||:|:||..||:|:|.|::.|...|..
Zfish  1436 KILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSN 1500

  Fly  1264 LLHNRHGYLHRFVEKTGV 1281
            |:..: |..::..:.:|:
Zfish  1501 LIAKK-GIFYKMAKDSGL 1517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	445/1361 (33%)
		ABC_membrane	92..358	CDD:294371	71/269 (26%)
		ABCC_MRP_domain1	423..626	CDD:213217	83/206 (40%)
		ABC_membrane	762..988	CDD:294371	63/232 (27%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	126/222 (57%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	448/1381 (32%)
		ABC_membrane	331..595	CDD:279056	70/267 (26%)
		ABCC_MRP_domain1	641..842	CDD:213217	83/206 (40%)
		ABC_membrane	966..1231	CDD:279056	74/285 (26%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	126/222 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750