DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC12

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001380726.1	Gene:	ABCC12 / 94160	HGNCID:	14640	Length:	1359	Species:	Homo sapiens

Alignment Length:	1435	Identity:	460/1435 - (32%)
Similarity:	735/1435 - (51%)	Gaps:	210/1435 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VRP-----KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLD----------SERV 58
            |||     .||...|...|..:|.|:..:..:|          |:.|.|:|          |:..
Human    35 VRPCARLAPNPVDDAGLLSFATFSWLTPVMVKG----------YRQRLTVDTLPPLSTYDSSDTN 89

  Fly    59 TNKFAELWEDELKRSNPSVVRM--ILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATN 121
            ..:|..||::|:.|..|....:  ::..:.:..|.|.:..:|...|..::.|..|...:    ..
Human    90 AKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPTVLIHQI----LQ 150

  Fly   122 QTDISENTAYLYAMGIVICMLVPVITFHPFIFYI------FQVGTKLRLALSGLIYRKVLQVSKS 180
            ||   |.|:....:||.:|:.:....|....|:.      ::...:|::|||.|::..::.. |:
Human   151 QT---ERTSGKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSF-KT 211

  Fly   181 SSNDGLRGRAINILSND-LGRFDVAL-CFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSF 243
            .::..: |..:||||:| ...|:.|| |.|..|.  |:..:......:..:|.:|:||:|..:.|
Human   212 LTHISV-GEVLNILSSDSYSLFEAALFCPLPATI--PILMVFCAAYAFFILGPTALIGISVYVIF 273

  Fly   244 IPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRG 308
            ||:|.:.||..:.:|:.....||.||:.|||.:..|::||||||||||...|.::|.:|.|.:..
Human   274 IPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEK 338

  Fly   309 TAYIHAALGCTS-MISPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIA 372
            ..::.:.....: ::|.:::.|.|..::.|...|||...::|.:.||::..| :...|.||..:|
Human   339 AGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFS-IAILPFSIKAMA 402

  Fly   373 EALVSAKRCKDFLLDGD------KAEVP--INLEANQQTGKNKRKISKKDKQKNVELNGSLLSNG 429
            ||.||.:|.|..|:|..      :.|.|  :.|.|| .|...:.:.|:|...|.::        .
Human   403 EANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLAN-ATLTWEHEASRKSTPKKLQ--------N 458

  Fly   430 QVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSF 494
            |..|...:......:::....|..:...:.||. ....:...|..::...:..:.|.||:||||.
Human   459 QKRHLCKKQRSEAYSERSPPAKGATGPEEQSDS-LKSVLHSISFVVRKGKILGICGNVGSGKSSL 522

  Fly   495 LNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMEL 559
            |..|||::.:.||...|:|.::|.||::|:|.|.:|:||:|.|.|:.:||:..|:||||::|:..
Human   523 LAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSN 587

  Fly   560 LPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSN 624
            ||.||||.:||||::|||||:.|:|||||||....:|||||||||||.|||||:|:.||:..|..
Human   588 LPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRG 652

  Fly   625 KIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQRSR-------------QFQ--------- 667
            |..:|||||:|:|...:.::|:..|:|..:|:::||...|             ||:
Human   653 KTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAA 717

  Fly   668 ----FLEQ--TQHDESGI---------DTHSVSSYLSRSDSEKSMEHQHNQLLRPDEHVEDVNQE 717
                |.|.  .:.:::||         |....|...|.....|..|||..|...|.|
Human   718 MVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQE-------- 774

  Fly   718 QQTVGSIKMHVYASYIKALDSTFLLGIVISLF-VCARIMLTGVDYFLSRWV-IWEEQIA------ 774
                |::....|.:||||..     |.::||| |...:::.|...|.:.|: :|.::.:
Human   775 ----GTVTWKTYHTYIKASG-----GYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGP 830

  Fly   775 -VNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLI-- 836
             .|||   :.|....:|:                       |.|.:   |..:..|:::..|:
Human   831 QGNRT---MCEVGAVLAD-----------------------IGQHV---YQWVYTASMVFMLVFG 866

  Fly   837 --RTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLP-HTLLDC 898
              :.|.|.|..|..|..|||.:|..|.::.|.||:|..:||::||||||:..:|..|| |.....
Human   867 VTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFL 931

  Fly   899 LAFIIDVSGVVIIVAIANYWLLIPAAI-IGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQT 962
            ..|.:.|..:||:.|:....||:.|:: :|..: ::| ::....:.:|::|::||||.|:....:
Human   932 QQFFMVVFILVILAAVFPAVLLVVASLAVGFFI-LLR-IFHRGVQELKKVENVSRSPWFTHITSS 994

  Fly   963 FQGLTTIRAL-QAQSALEQEFHEYQNTNTSAWFLFLSCT-RAFALWSDVLCIVYMTAVTFSFLLL 1025
            .|||..|.|. :.:|.:  .:|          .|:.:|. |.|||..|||    |..:||:..||
Human   995 MQGLGIIHAYGKKESCI--TYH----------LLYFNCALRWFALRMDVL----MNILTFTVALL 1043

  Fly  1026 K----DEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKF 1086
            .    ....:...||::.:...::|:.|..:|...|.:.:.||||.:.||.   |..:.|.....
Human  1044 VTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYI---STCVPECTHPL 1105

  Fly  1087 K----PKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFR 1147
            |    || :|||:|.|.|.::::||......||..||..|:..:.:|||||||:||||:..::||
Human  1106 KVGTCPK-DWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFR 1169

  Fly  1148 LA-CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVE 1211
            |. ...|.|.||:|||..:.|.|||:::::||||||||.||:||||||.:..:||.:|:.|....
Human  1170 LVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTF 1234

  Fly  1212 LRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTI 1276
            :|..:..|...|...:.:.|.|||||:|||:|:|||:||::||:::|||||::|.:||.|:|.||
Human  1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTI 1299

  Fly  1277 RSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFAL 1341
            :..|..||||||||||:||::.|.||||:.|:|.|...|..|.::..             ::||:
Human  1300 KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPD-------------SAFAM 1351

  Fly  1342 QQAAE 1346
            ..|||
Human  1352 LLAAE 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	454/1422 (32%)
		ABC_membrane	94..360	CDD:294371	76/274 (28%)
		ABCC_MRP_domain1	448..650	CDD:213217	91/201 (45%)
		ABC_membrane	821..1046	CDD:294371	69/236 (29%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	108/219 (49%)
ABCC12	NP_001380726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..491		7/52 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660