DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdog and ABCC10

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_016866934.1	Gene:	ABCC10 / 89845	HGNCID:	52	Length:	1558	Species:	Homo sapiens

Alignment Length:	1373	Identity:	435/1373 - (31%)
Similarity:	689/1373 - (50%)	Gaps:	153/1373 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NFFSQWSFWWMRDLFKRGLQGPLTDEE---LYQHRKTLDSERVTNKFAELWEDELKRSNPSVVRM 80
            ::.|::|:.|:..|..||..|.|...:   ...||  |....:...|...|::..:     :.|.
Human   270 SWLSRFSYAWLAPLLARGACGELRQPQDICRLPHR--LQPTYLARVFQAHWQEGAR-----LWRA 327

  Fly    81 ILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVICMLVPV 145
            :..|:|:.::.:|| ..:..|:.....||.|..|||:....|..:|.  ..|||:|:....::..
Human   328 LYGAFGRCYLALGL-LKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSH--GLLYALGLAGGAVLGA 389

  Fly   146 ITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHD 210
            :..:.:.:.:::|..:.|.|:..::|.|.||:..|...   .|.|:|:|..|..|........|:
Human   390 VLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPP---TGEALNLLGTDSERLLNFAGSFHE 451

  Fly   211 TWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEI 275
            .|..|::..:..:|:|:::|::.|.|:...|..:|:....|.:.....|...:..|.||||:.|:
Human   452 AWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTEL 516

  Fly   276 IQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISPLSVFLAL---CSYVYL 337
            :.||:|||...||::....:...|.:|:..:|...|:.||  |..:.:.|.|.:::   .:||.:
Human   517 LSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAA--CVYLWAALPVVISIVIFITYVLM 579

  Fly   338 GDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQ 402
            |..|||.||:|..:...||...:..| |..|..:.||.||..|.:.||      ::|
Human   580 GHQLTATKVFTALALVRMLILPLNNF-PWVINGLLEAKVSLDRIQLFL------DLP-------- 629

  Fly   403 TGKNKRKISKKD-KQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVV-LKNVSASWDTSDGHAN 465
             ..|.:.....| .:...::...|.|            ||.|....|: |.....|||.    ..
Human   630 -NHNPQAYYSPDCGRLGAQIKWLLCS------------DPPAEPSTVLELHGALFSWDP----VG 677

  Fly   466 CAIEDFST--DIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHG---KISYASQESWVF 525
            .::|.|.:  ::|...|..:||.||.||||.|..:.||:...:|...|.|   ....|:||.|:.
Human   678 TSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQ 742

  Fly   526 EGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVY 590
            ..||||||:|.:.::.:.||:|::.|.|..|:.:||.||.|.|||:||:|||||:||::||||||
Human   743 FATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVY 807

  Fly   591 RKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQG 655
            ::.::|||||||:|||..|..|:..|||...||...|:|.||:.:||...:.:|||.:|:::..|
Human   808 QEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAG 872

  Fly   656 SYQELQRSRQFQFLEQTQ-----HDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPDEHVEDVN 715
            ...|:        |...|     ..|:|          ..|||..:...|:     |::..|.:.
Human   873 PPSEI--------LPLVQAVPKAWAENG----------QESDSATAQSVQN-----PEKTKEGLE 914

  Fly   716 QEQQT-----------VGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWVIW 769
            :||.|           .|::.:|||.:|.||:.....|.|:.||.: .:......|::||.|:
Human   915 EEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLL-MQATRNAADWWLSHWI-- 976

  Fly   770 EEQIAVNRTTTLLNETDTTIA--------------NDTLPINATDPYIAPLLASDIQAGIRQELV 820
             .|:....::.....:.:..:              |..:|:... |..||..:|||:.     .:
Human   977 -SQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPL-PKAAPNGSSDIRF-----YL 1034

  Fly   821 LFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIR 885
            ..||||.|...:..|:|...|....|:.:..||.||...:..|.:.|||...:||||||||.|:.
Human  1035 TVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVA 1099

  Fly   886 TVDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESI 950
            ..|..||..|...||....:.|::.::.....|||:....:.::...::..|..:||.::||.|:
Human  1100 CADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSL 1164

  Fly   951 SRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYM 1015
            :.||::|....|..||:.:||..|....|:|.......|....|    .|.|...|.|:...:..
Human  1165 TLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQF----ATSATMQWLDIRLQLMG 1225

  Fly  1016 TAVTFS---FLLLKDE---FDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYT-E 1073
            .||..:   ..|::.:   .:.|.|||::.::.::||:....:....:.|..:.||||:.||| :
Human  1226 AAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCD 1290

  Fly  1074 QPSEALLETPEKFKPKSE-------WPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIV 1131
            .|.|          |:.:       |.::|.:||.:..|.|.|.....|..:.|.::|.||:|||
Human  1291 LPQE----------PQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIV 1345

  Fly  1132 GRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPM 1195
            ||||:||||::..:|| |..:.|.:.:|.||...:.|..||||::||||:|.|||||:|.||||.
Human  1346 GRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQ 1410

  Fly  1196 DERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEA 1260
            ....|..:|:||....| |.|.|.:|||:..:.:||.:.|:|||||:|||||:|...|||.:|||
Human  1411 GLHKDRALWQALKQCHL-SEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEA 1474

  Fly  1261 TANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGY 1325
            ||:||.:||:|:||||..:||:.|||||||||:|:::||||||:.||.|.||..|..|..:....
Human  1475 TASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSL 1539

  Fly  1326 LRQLVDNT 1333
            .:||:.::
Human  1540 FQQLLQSS 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	435/1373 (32%)
		ABC_membrane	94..360	CDD:294371	73/268 (27%)
		ABCC_MRP_domain1	448..650	CDD:213217	89/207 (43%)
		ABC_membrane	821..1046	CDD:294371	66/230 (29%)
		ABCC_MRP_domain2	1096..1315	CDD:213211	114/219 (52%)
ABCC10	XP_016866934.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650