Protein Alignment rdog and ABCC3

DIOPT Version :10

• Sequence 1: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_003777.2
• Gene: ABCC3 / 8714
• HGNCID: 54
• Length: 1527
• Species: Homo sapiens
• Alignment Length: 1436
• Identity: 471/1436 - (32%)
• Similarity: 727/1436 - (50%)
• Gaps: 239/1436 - (16%)

  Fly     7 KVVRPKNPF--TKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELW--- 66
            |.|.| ||:  |.|.|.|:..|||...:...|.:.||.:::|:..::...|:.|..:..|.|
Human   200 KNVDP-NPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQ 263

  Fly    67 -------------------EDEL------KRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSL 106
                               |||:      :...||.::.:|..:|..|: :...|.:.:.:...:
Human   264 EKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFL-ISACFKLIQDLLSFI 327

  Fly   107 MPLFLGGLVGYFATNQTDISENTA-----YLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLAL 166
            .|..|..|:.:       ||...|     :|.|..:.:|.::..:....:..|||..|.|.|..:
Human   328 NPQLLSILIRF-------ISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGI 385

  Fly   167 SGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREIGI 231
            .|:||||.|.::.|.......|..:|::|.|..||.....||:..|..|::.||..:.:::.:|.
Human   386 MGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGP 450

  Fly   232 SAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIA 296
            |.:.||:||:..|||....|.|...::....:..|.|:|||:||:.||:|:|:||||.||.:.:.
Human   451 SVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVE 515

  Fly   297 EVRLKEVKAIRGTAYIHAALGCTSMISP-LSVFLALCSYVYLGDP---LTAQKVYTVSSYFNMLN 357
            .:|..|::.:|..||:|.....|.|.|| |...:.|..|||: ||   |.|:|.:...|.||:|.
Human   516 GIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYV-DPNNVLDAEKAFVSVSLFNILR 579

  Fly   358 DSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLEANQQTGKNKRKISKKDKQKNVELN 422
             ..:...|..|:.:.:|.||.||.:.||              :|:
Human   580 -LPLNMLPQLISNLTQASVSLKRIQQFL--------------SQE-------------------- 609

  Fly   423 GSLLSNGQVHHNRLRDYDPEATKK-------CVVLKNVSASWDTSDGHANCAIEDF-----STDI 475
                           :.||::.::       .:.:.:.:.:|          .:|.     |.||
Human   610 ---------------ELDPQSVERKTISPGYAITIHSGTFTW----------AQDLPPTLHSLDI 649

  Fly   476 K--DQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVH--GKISYASQESWVFEGTIRDNIVFV 536
            :  ...|.|||||||.||||.::.||||  ::|.|..||  |.::|..|::|:...|:::|::|.
Human   650 QVPKGALVAVVGPVGCGKSSLVSALLGE--MEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFG 712

  Fly   537 EDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDP 601
            :..|.:||::.::.|.|..|:|:||.||.|.:||:|::|||||:.|||||||||..|||:|||||
Human   713 KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDP 777

  Fly   602 LSAVDTHVGKHIFDRCI--RDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQE-LQRS 663
            |||||:||.|||||..|  ...|:.|.|:||||.:.:|...:.::::..|::...|.|.. |||:
Human   778 LSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRN 842

  Fly   664 RQF--------------------QFLEQTQHDESGIDTHSVSSYLSRSDS-------EKSMEHQH 701
            ..|                    ..||..:..|:.:...::|::...:|:       :|....|.
Human   843 GSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQL 907

  Fly   702 NQL---------------LRPDEHVED---------VNQEQQTVGSIKMHVYASYIKALDSTFLL 742
            :.|               |.|.|.|:.         ..:|:..:|::::.|:..|.||:.....|
Human   908 SALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTL 972

  Fly   743 GIVISLFVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLL 807
            .|.: |:|.......|.:.:||.|.  .:.:|.:|..           |.:|.:..   |.|
Human   973 AICL-LYVGQSAAAIGANVWLSAWT--NDAMADSRQN-----------NTSLRLGV---YAA--- 1017

  Fly   808 ASDIQAGIRQELVLFYATILGATLIVYLIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNS 872
                 .||.|..::..|.:..|...:...|.             ||..|.....|:...||:|..
Human  1018 -----LGILQGFLVMLAAMAMAAGGIQAARV-------------LHQALLHNKIRSPQSFFDTTP 1064

  Fly   873 SGRILNRFSKDIRTVDTDLPHTLLDCL-AFIIDVSGVVIIVAIANYW--LLIPAAIIGVILGMIR 934
            ||||||.|||||..||..|...:|..| :|...:|.:|:|:|....:  :::|.|   |:..:::
Human  1065 SGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLA---VLYTLVQ 1126

  Fly   935 YLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSC 999
            ..|..|||.:|||||:||||::|..::|..|.:.|||.......|.......:.|..:.:.::..
Human  1127 RFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIIS 1191

  Fly  1000 TRAFALWSDVL--CIVYMTAVTFSFLLL-KDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQ 1061
            .|..::..:.:  |:|...|:   |.:: :...:.|.|||::.:|..:|....|.:|..::||:.
Human  1192 NRWLSIGVEFVGNCVVLFAAL---FAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESN 1253

  Fly  1062 MTSVERVLEYTEQPSEALLETP---EKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIE 1123
            :.:||||.||::..:||    |   |..:|...||.:|.:||.|:.:||.|....||:||:..:.
Human  1254 IVAVERVKEYSKTETEA----PWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVH 1314

  Fly  1124 PREKIGIVGRTGAGKSSIIQSIFR-LACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGT 1187
            ..||:||||||||||||:...:|| |...:|.||||.:::..|||||||||::||||||:|||||
Human  1315 GGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379

  Fly  1188 LRYNLDPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHN 1252
            ||.||||....|:|::|.||....|.::||:...||:.:..:||.|.|||||||||||||:||.:
Human  1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKS 1444

  Fly  1253 KILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYE 1317
            :||::|||||.:|.|||.|||.|||::|..||||||||||:|:||..||||:|.|.|.|...|..
Human  1445 RILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPAN 1509

  Fly  1318 LLQRTG 1323
            |:...|
Human  1510 LIAARG 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	466/1427 (33%)
ABCC3	NP_003777.2	MRP_assoc_pro	7..1526	CDD:188098	471/1436 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	910..932		4/21 (19%)