DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdog and YKR104W

DIOPT Version :9

Sequence 1:	NP_651678.1	Gene:	rdog / 43450	FlyBaseID:	FBgn0039644	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_013030.1	Gene:	YKR104W / 853979	SGDID:	S000001812	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	293	Identity:	128/293 - (43%)
Similarity:	174/293 - (59%)	Gaps:	24/293 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1062 MTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPRE 1126
            |:||||:.|||:.||    |:.....|.:.||..|.:|..|..|||||..:..|.:::|.::...
Yeast     1 MSSVERIKEYTDIPS----ESNGYISPPANWPQTGDVELKNLSLRYSPHSSKALDNVSFKVKAGT 61

  Fly  1127 KIGIVGRTGAGKSSIIQSIFRLA-CNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRY 1190
            |:||||||||||||||.:|:||: ...|.|.||:.||:||.|..||:.:|.|||||.||.||:|.
Yeast    62 KVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDGTVRS 126

  Fly  1191 NLDPMDERSDEEMWKALGDVELRSYVSTL-------------------IGGLNCRMYDGGSNFSV 1236
            ||||.|..||.:::..|..|.|......|                   ...||..:..||||.|.
Yeast   127 NLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGSNLSQ 191

  Fly  1237 GQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRV 1301
            |||||:||||::|....|:::|||||::|..:|..||:|||....:.|:|||||||.:|:|.|::
Yeast   192 GQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVIDYDKI 256

  Fly  1302 LVMDAGEVRELGHPYELLQRTGGYLRQLVDNTG 1334
            |||:.|.|:|..|||.|:........:|...:|
Yeast   257 LVMEMGRVKEYDHPYTLISDRNTIFYRLCRQSG 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdog	NP_651678.1	CFTR_protein	12..1343	CDD:273530	128/293 (44%)
		ABC_membrane	94..360	CDD:294371
		ABCC_MRP_domain1	448..650	CDD:213217
		ABC_membrane	821..1046	CDD:294371
		ABCC_MRP_domain2	1096..1315	CDD:213211	108/238 (45%)
YKR104W	NP_013030.1	ABCC_NFT1	27..270	CDD:213269	110/242 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830