DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdog and STE6

DIOPT Version :9

Sequence 1:NP_651678.1 Gene:rdog / 43450 FlyBaseID:FBgn0039644 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_012713.1 Gene:STE6 / 853671 SGDID:S000001692 Length:1290 Species:Saccharomyces cerevisiae


Alignment Length:1404 Identity:303/1404 - (21%)
Similarity:551/1404 - (39%) Gaps:343/1404 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 TFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGR-FDVALCFL-H 209
            |.|..||....:....||.:..:|         .:...||.....:||:   || ||:...|: :
Yeast     9 TKHYHIFRYVNIRNDYRLLMIMII---------GTVATGLVPAITSILT---GRVFDLLSVFVAN 61

  Fly   210 DTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAW------------AAKKAAYYRQMTA 262
            .:.:|     |...|:.|.:.:.|:...|..:.::.|.:|            :....||..:...
Yeast    62 GSHQG-----LYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQILEAYLEEKPM 121

  Fly   263 ERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHA-----ALGCTSMI 322
            |..|...||:.:..|..:.::......:.|..|....|..:.|:.||::.::     .:.|:   
Yeast   122 EWYDNNEKLLGDFTQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCS--- 183

  Fly   323 SPLSVFLALCSYVYLGDPLTAQKVYTVSSYFNMLND--SMVTFWPMS----ITFIAEALVSAKRC 381
            ||:..|.|:         :.::.::..|...|....  :.:..|.|:    :.......:..|:.
Yeast   184 SPIITFFAV---------VFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKF 239

  Fly   382 KDFLLDGD-------------------------------------KAEVPIN------------- 396
            |:.:|:.:                                     |.::.||             
Yeast   240 KEIILNCNTFFIKSCFFVAANAGILRFLTLTMFVQGFWFGSAMIKKGKLNINDVITCFHSCIMLG 304

  Fly   397 ---------LEANQQTGKNKRKISK--KDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVL 450
                     :...|:.|....||..  ||..|...||.:      |.|....||   ||.. :..
Yeast   305 STLNNTLHQIVVLQKGGVAMEKIMTLLKDGSKRNPLNKT------VAHQFPLDY---ATSD-LTF 359

  Fly   451 KNVSASWDTSDGHANCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLL-------GEVGIDK-- 506
            .|||.|:.:....|  .:::.|.:........:||..|:|||:..|:||       |.:.|:.  
Yeast   360 ANVSFSYPSRPSEA--VLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHN 422

  Fly   507 ----GEAMVHGKISYASQESWVFEGTIRDNIVFVE---------DYNERRY--KKVVKVCGLERD 556
                .:.::...|:...|...:|..|:|.||:...         ..||.|:  |...::..|:|.
Yeast   423 IQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRF 487

  Fly   557 MELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDF 621
            :..||.|..|::|..||:|||||:.||::|||..|...|..||:.:||:|. |.:::..:.||.:
Yeast   488 ILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDI-VHRNLLMKAIRHW 551

  Fly   622 LSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQEL--QRSRQFQFLEQTQHDESG----ID 680
            ...|..|::||::..:...::|.||..|:::..|:..||  ..:..|......|:|.|.    :|
Yeast   552 RKGKTTIILTHELSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVD 616

  Fly   681 T-------HSVSSYLSRSDSEK------SMEHQHNQLL---------RPDEHVEDVNQEQQTVG- 722
            |       |:|.|:.|:.::.|      ::.:.....|         |.:.....|..|::.:| 
Yeast   617 TETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGY 681

  Fly   723 SIK----------------MHVYASYIKAL--DSTFLLGIVISLFVCARIMLTGVDYFLSRWVIW 769
            ::|                :.:....||::  ....:||::.||...|                 
Yeast   682 ALKQQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLCSLIAGA----------------- 729

  Fly   770 EEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVY 834
                    |..:.:.|.:.:....:|            ::|.:.|....|..:...:||......
Yeast   730 --------TNPVFSYTFSFLLEGIVP------------STDGKTGSSHYLAKWSLLVLGVAAADG 774

  Fly   835 LIR-TFGFFKMCLR--ISLHLHDRLFRGITRASMYFFN------TNSSGRILNRFSKDIRTVDTD 890
            :.. ..||...|..  ..:.|.:.:...:||.:|.:|:      :..|..:||.. :|:|::.::
Yeast   775 IFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDL-RDLRSLVSE 838

  Fly   891 LPHTLLDCLAFIIDVSGVVIIVAIANYW------------LLIPAAIIGVILGMIRYLYVNTSRS 943
                .|..:...:.||.:.:|.|:.:.|            ::|.:||.|.||             
Yeast   839 ----FLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLIIIFSAIYGGIL------------- 886

  Fly   944 VKRLESISRSPVFSLTNQTFQGLT---TIRALQAQSALEQEFHEYQ-------NTNTSAWFLFLS 998
             ::.|:..::.|..|.|..:|.:|   ||:.|||:...:..:|:.:       :....|....:|
Yeast   887 -QKCETDYKTSVAQLENCLYQIVTNIKTIKCLQAEFHFQLTYHDLKIKMQQIASKRAIATGFGIS 950

  Fly   999 CTRAFALWSDVLCIVYMTAVTFSF---LLLKDEFDSGDVG-------LAILHSTTMTGM------ 1047
            .|...     |:||   .|:.:.:   |::..|:.|.::.       ..|:..|::...      
Yeast   951 MTNMI-----VMCI---QAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISR 1007

  Fly  1048 ----CQWGMR------QTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKSEWPSKGRIEFIN 1102
                ..|..|      .|.|:||.......:..:|....|                .|..:...|
Yeast  1008 GQRAASWIYRILDEKHNTLEVENNNARTVGIAGHTYHGKE----------------KKPIVSIQN 1056

  Fly  1103 FKLRY-SPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRL-ACNEGMIRIDDVDIEHI 1165
            ....| |...|.|.|::||.:...:.:||:|.:|.|||:::..:.:| .|..|.|:||..|:...
Yeast  1057 LTFAYPSAPTAFVYKNMNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDW 1121

  Fly  1166 GLHDLRSQVSIIPQDPVLFSGTLRYNL--DPMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMY 1228
            .|..||.::|::.|.|:||:||:|.||  ...||..:.||:.||..|.:..:|.:...||:.|: 
Yeast  1122 NLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILEIEMYDALKYVGIHDFVISSPQGLDTRI- 1185

  Fly  1229 DGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLH 1293
             ..:..|.||.|.:|:|||:||.:||||:||.|:.:|..:..:|.:.::........:.|.|...
Yeast  1186 -DTTLLSGGQAQRLCIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQ 1249

  Fly  1294 TVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDN 1332
            .:...:.:.|:..|:|.|.|: ::.|....|.|.|:|.|
Yeast  1250 MMRSCNSIAVLKDGKVVERGN-FDTLYNNRGELFQIVSN 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdogNP_651678.1 CFTR_protein 12..1343 CDD:273530 303/1404 (22%)
ABC_membrane 94..360 CDD:294371 44/233 (19%)
ABCC_MRP_domain1 448..650 CDD:213217 64/225 (28%)
ABC_membrane 821..1046 CDD:294371 51/265 (19%)
ABCC_MRP_domain2 1096..1315 CDD:213211 72/222 (32%)
STE6NP_012713.1 MdlB 24..605 CDD:224055 132/622 (21%)
MdlB 702..1289 CDD:224055 151/669 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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